Association of ABCB1, 5-HT3B Receptor and CYP2D6 Genetic Polymorphisms with Ondansetron and Metoclopramide Antiemetic Response in Indonesian Cancer Patients Treated with Highly Emetogenic Chemotherapy

Objective Suboptimal treatment of chemotherapy-induced nausea and vomiting and unsatisfactory response to antiemetic drugs cause impairment of cancer patient's daily functioning. This study was aimed to investigate the association of selected germline polymorphisms with ondansetron and metoclop...

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Veröffentlicht in:	Japanese journal of clinical oncology 2011-10, Vol.41 (10), p.1168-1176
Hauptverfasser:	Perwitasari, Dyah A., Wessels, Judith A.M., van der Straaten, Robert J.H.M., Baak-Pablo, Renee F., Mustofa, Mustofa, Hakimi, Mohammad, Nortier, Johann W.R., Gelderblom, Hans, Guchelaar, Henk-Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiemetics - pharmacokinetics Antiemetics - pharmacology Antineoplastic Agents - adverse effects ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cisplatin - adverse effects Cytochrome P-450 CYP2D6 - genetics Female Haplotypes - genetics Humans Indonesia Male Metoclopramide - pharmacokinetics Metoclopramide - pharmacology Middle Aged Nausea - chemically induced Nausea - genetics Neoplasms - drug therapy Ondansetron - pharmacokinetics Ondansetron - pharmacology Polymorphism, Single Nucleotide Receptors, Serotonin, 5-HT3 - genetics Vomiting - chemically induced Vomiting - genetics
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