Inhibition of protein phosphatase PPM1D enhances retinoic acid-induced differentiation in human embryonic carcinoma cell line

Abstract The protein phosphatase PPM1D (Wip1) was originally identified as a p53 target product. Activation of PPM1D through various mechanism promotes the tumorigenic potential of various cancers by suppressing p53 and other DNA damage response proteins. New functions of PPM1D have recently been re...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2019-06, Vol.165 (6), p.471-477
Hauptverfasser:	Ogasawara, Sari, Chuman, Yoshiro, Michiba, Takahiro, Kamada, Rui, Imagawa, Toshiaki, Sakaguchi, Kazuyasu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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