Drug solubilization effect of lauroyl-L-glutamate
This article proposes a new technique for the solubilization of poorly soluble drugs using lauroyl-L-glutamate, which is one of the amino acid detergents, with additional small additives. Lauroyl-L-glutamate was highly effective in solubilizing long-chain alkyl gallates, e.g. dodecyl gallate. Furthe...
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| Veröffentlicht in: | Journal of biochemistry (Tokyo) 2012-01, Vol.151 (1), p.27-33 |
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| container_title | Journal of biochemistry (Tokyo) |
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| creator | Ariki, Ryosuke Hirano, Atsushi Arakawa, Tsutomu Shiraki, Kentaro |
| description | This article proposes a new technique for the solubilization of poorly soluble drugs using lauroyl-L-glutamate, which is one of the amino acid detergents, with additional small additives. Lauroyl-L-glutamate was highly effective in solubilizing long-chain alkyl gallates, e.g. dodecyl gallate. Furthermore, lauroyl-L-glutamate and small additives, particularly arginine, acted to increase the solubility of alkyl gallates. The synergistic effect was not observed by sodium dodecyl sulphate with arginine. The solubilizing system can be applied to other drugs because of the low toxicity of both lauroyl-L-glutamate and arginine. |
| doi_str_mv | 10.1093/jb/mvr117 |
| format | Article |
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Lauroyl-L-glutamate was highly effective in solubilizing long-chain alkyl gallates, e.g. dodecyl gallate. Furthermore, lauroyl-L-glutamate and small additives, particularly arginine, acted to increase the solubility of alkyl gallates. The synergistic effect was not observed by sodium dodecyl sulphate with arginine. The solubilizing system can be applied to other drugs because of the low toxicity of both lauroyl-L-glutamate and arginine.</description><identifier>ISSN: 0021-924X</identifier><identifier>EISSN: 1756-2651</identifier><identifier>DOI: 10.1093/jb/mvr117</identifier><identifier>PMID: 21949409</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Algorithms ; Arginine - chemistry ; Arginine - pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Energy Transfer ; Gallic Acid - analogs & derivatives ; Gallic Acid - chemistry ; Glutamates - chemistry ; Glutamates - pharmacology ; Models, Chemical ; Pharmaceutical Preparations - chemistry ; Sodium Dodecyl Sulfate - chemistry ; Sodium Dodecyl Sulfate - pharmacology ; Solubility - drug effects ; Technology, Pharmaceutical - methods</subject><ispartof>Journal of biochemistry (Tokyo), 2012-01, Vol.151 (1), p.27-33</ispartof><rights>The Authors 2011. 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Lauroyl-L-glutamate was highly effective in solubilizing long-chain alkyl gallates, e.g. dodecyl gallate. Furthermore, lauroyl-L-glutamate and small additives, particularly arginine, acted to increase the solubility of alkyl gallates. The synergistic effect was not observed by sodium dodecyl sulphate with arginine. The solubilizing system can be applied to other drugs because of the low toxicity of both lauroyl-L-glutamate and arginine.</description><subject>Algorithms</subject><subject>Arginine - chemistry</subject><subject>Arginine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Energy Transfer</subject><subject>Gallic Acid - analogs & derivatives</subject><subject>Gallic Acid - chemistry</subject><subject>Glutamates - chemistry</subject><subject>Glutamates - pharmacology</subject><subject>Models, Chemical</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Sodium Dodecyl Sulfate - chemistry</subject><subject>Sodium Dodecyl Sulfate - pharmacology</subject><subject>Solubility - drug effects</subject><subject>Technology, Pharmaceutical - methods</subject><issn>0021-924X</issn><issn>1756-2651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j0tLxDAYRYMozji68A9IF25cxMm7zVJmfEHBjYK7ki9NhpbWlrQRxl9vh6pLV5cLh8s9CF1SckuJ5usa1u1noDQ9QkuaSoWZkvQYLQlhFGsm3hfobBjqQ2Wcn6IFo1poQfQS0W2Iu2TomghVU32Zseo-Eue9s2PS-aQxMXT7Bud418TRtGZ05-jEm2ZwFz-5Qm8P96-bJ5y_PD5v7nJsuRIjlqWATHgyXTEaICOZyrTi3kjwgqegmDKgSkm89ZmXwIBxSMFJC5mzqeUrdDPv2tANQ3C-6EPVmrAvKCkO2kUNxaw9sVcz20doXflH_npOwPUMdLH_Z-cbPm1gUg</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Ariki, Ryosuke</creator><creator>Hirano, Atsushi</creator><creator>Arakawa, Tsutomu</creator><creator>Shiraki, Kentaro</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201201</creationdate><title>Drug solubilization effect of lauroyl-L-glutamate</title><author>Ariki, Ryosuke ; Hirano, Atsushi ; Arakawa, Tsutomu ; Shiraki, Kentaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-5d4b84f0265a9bb80868963fa5bf437b626ab6d50fcf8f5b2b23b7be5cb8ec7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Algorithms</topic><topic>Arginine - chemistry</topic><topic>Arginine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Energy Transfer</topic><topic>Gallic Acid - analogs & derivatives</topic><topic>Gallic Acid - chemistry</topic><topic>Glutamates - chemistry</topic><topic>Glutamates - pharmacology</topic><topic>Models, Chemical</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Sodium Dodecyl Sulfate - chemistry</topic><topic>Sodium Dodecyl Sulfate - pharmacology</topic><topic>Solubility - drug effects</topic><topic>Technology, Pharmaceutical - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ariki, Ryosuke</creatorcontrib><creatorcontrib>Hirano, Atsushi</creatorcontrib><creatorcontrib>Arakawa, Tsutomu</creatorcontrib><creatorcontrib>Shiraki, Kentaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ariki, Ryosuke</au><au>Hirano, Atsushi</au><au>Arakawa, Tsutomu</au><au>Shiraki, Kentaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug solubilization effect of lauroyl-L-glutamate</atitle><jtitle>Journal of biochemistry (Tokyo)</jtitle><addtitle>J Biochem</addtitle><date>2012-01</date><risdate>2012</risdate><volume>151</volume><issue>1</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0021-924X</issn><eissn>1756-2651</eissn><abstract>This article proposes a new technique for the solubilization of poorly soluble drugs using lauroyl-L-glutamate, which is one of the amino acid detergents, with additional small additives. 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| fulltext | fulltext |
| identifier | ISSN: 0021-924X |
| ispartof | Journal of biochemistry (Tokyo), 2012-01, Vol.151 (1), p.27-33 |
| issn | 0021-924X 1756-2651 |
| language | eng |
| recordid | cdi_crossref_primary_10_1093_jb_mvr117 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Algorithms Arginine - chemistry Arginine - pharmacology Dose-Response Relationship, Drug Drug Synergism Energy Transfer Gallic Acid - analogs & derivatives Gallic Acid - chemistry Glutamates - chemistry Glutamates - pharmacology Models, Chemical Pharmaceutical Preparations - chemistry Sodium Dodecyl Sulfate - chemistry Sodium Dodecyl Sulfate - pharmacology Solubility - drug effects Technology, Pharmaceutical - methods |
| title | Drug solubilization effect of lauroyl-L-glutamate |
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