Compensation of Matrix Effects in a Standard Addition Method for Metformin in Postmortem Blood Using Liquid Chromatography–Electrospray–Tandem Mass Spectrometry

This work describes a procedure to evaluate matrix effects in a combined dilution and standard addition method (SAM) using liquid chromatography–electrospray–tandem mass spectrometry. The method was validated and applied to an analysis of metformin in postmortem blood samples. The analytical method...

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Veröffentlicht in:	Journal of analytical toxicology 2015-06, Vol.39 (5), p.359-364
Hauptverfasser:	Gergov, Merja, Nenonen, Timo, Ojanperä, Ilkka, Ketola, Raimo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autopsy Calibration Chromatography, Reverse-Phase - standards Humans Hypoglycemic Agents - blood Limit of Detection Linear Models Metformin - blood Reference Standards Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - standards Tandem Mass Spectrometry - standards
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