When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus
Abstract Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent failure of antimicrobial therapy despite s...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2020-05, Vol.75 (5), p.1071-1086 |
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| container_issue | 5 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Kuehl, Richard Morata, Laura Meylan, Sylvain Mensa, Josep Soriano, Alex |
| description | Abstract
Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent failure of antimicrobial therapy despite susceptibility in standard microbiological assays. Bacteria capable of surviving high antibiotic concentrations despite having a genetically susceptible background are described as ‘antibiotic tolerant’. In this review, we put current knowledge on environmental triggers and molecular mechanisms of increased antibiotic survival of S. aureus into its clinical context. We discuss animal and clinical evidence of its significance and outline strategies to overcome infections with antibiotic-tolerant S. aureus. |
| doi_str_mv | 10.1093/jac/dkz559 |
| format | Article |
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Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent failure of antimicrobial therapy despite susceptibility in standard microbiological assays. Bacteria capable of surviving high antibiotic concentrations despite having a genetically susceptible background are described as ‘antibiotic tolerant’. In this review, we put current knowledge on environmental triggers and molecular mechanisms of increased antibiotic survival of S. aureus into its clinical context. We discuss animal and clinical evidence of its significance and outline strategies to overcome infections with antibiotic-tolerant S. aureus.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkz559</identifier><identifier>PMID: 32016348</identifier><language>eng</language><publisher>OXFORD: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Drug Resistance, Bacterial ; Humans ; Infectious Diseases ; Life Sciences & Biomedicine ; Microbiology ; Pharmacology & Pharmacy ; Science & Technology ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus</subject><ispartof>Journal of antimicrobial chemotherapy, 2020-05, Vol.75 (5), p.1071-1086</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>35</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000537415500001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c383t-6138d8c2f189ea3a3c2324bb7df004a00c1ceb601b652b53f7d45b1002c732933</citedby><cites>FETCH-LOGICAL-c383t-6138d8c2f189ea3a3c2324bb7df004a00c1ceb601b652b53f7d45b1002c732933</cites><orcidid>0000-0001-5795-0814 ; 0000-0002-9374-0811 ; 0000-0002-4959-0983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27929,27930,28253</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32016348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuehl, Richard</creatorcontrib><creatorcontrib>Morata, Laura</creatorcontrib><creatorcontrib>Meylan, Sylvain</creatorcontrib><creatorcontrib>Mensa, Josep</creatorcontrib><creatorcontrib>Soriano, Alex</creatorcontrib><title>When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J ANTIMICROB CHEMOTH</addtitle><addtitle>J Antimicrob Chemother</addtitle><description>Abstract
Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent failure of antimicrobial therapy despite susceptibility in standard microbiological assays. Bacteria capable of surviving high antibiotic concentrations despite having a genetically susceptible background are described as ‘antibiotic tolerant’. In this review, we put current knowledge on environmental triggers and molecular mechanisms of increased antibiotic survival of S. aureus into its clinical context. We discuss animal and clinical evidence of its significance and outline strategies to overcome infections with antibiotic-tolerant S. aureus.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Drug Resistance, Bacterial</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Life Sciences & Biomedicine</subject><subject>Microbiology</subject><subject>Pharmacology & Pharmacy</subject><subject>Science & Technology</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtv1TAQRi1ERW8LG34A8gYJFYWOPXEe7NAVL6kSC0AsI3viUBffOMQOqF3yy-vbtBUrxMqPOd_Ic8zYUwGvBLR4eqHptP9xpVT7gG1EWUEhoRUP2QYQVFGXCg_ZUYwXAFCpqnnEDlGCqLBsNuzPt3M7cj0mZ1xIjiIftPOvuebk3ehI-1zs-c7RHDLhw_ebu8nOcbKU3C_Lw995noK3sx7J3uT2nIvJ7s9h4J-Tns4vfaBAtESul9ku8TE7GLSP9sntesy-vnv7ZfuhOPv0_uP2zVlB2GAqKoFN35AcRNNajRpJoiyNqfsBoNQAJMiaCoSplDQKh7ovlREAkmqULeIxe7H2nebwc7ExdTsXyXqvRxuW2ElU0AJWZZPRkxXNU8c426GbZrfT82UnoNs777LzbnWe4We3fRezs_09eic5A80K_LYmDJHcXsc9ln9FYV0KpfIOxNYlnVwYt2EZU46-_P9opp-vdFimf734Grg9rSk</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Kuehl, Richard</creator><creator>Morata, Laura</creator><creator>Meylan, Sylvain</creator><creator>Mensa, Josep</creator><creator>Soriano, Alex</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5795-0814</orcidid><orcidid>https://orcid.org/0000-0002-9374-0811</orcidid><orcidid>https://orcid.org/0000-0002-4959-0983</orcidid></search><sort><creationdate>20200501</creationdate><title>When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus</title><author>Kuehl, Richard ; Morata, Laura ; Meylan, Sylvain ; Mensa, Josep ; Soriano, Alex</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-6138d8c2f189ea3a3c2324bb7df004a00c1ceb601b652b53f7d45b1002c732933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Drug Resistance, Bacterial</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Life Sciences & Biomedicine</topic><topic>Microbiology</topic><topic>Pharmacology & Pharmacy</topic><topic>Science & Technology</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuehl, Richard</creatorcontrib><creatorcontrib>Morata, Laura</creatorcontrib><creatorcontrib>Meylan, Sylvain</creatorcontrib><creatorcontrib>Mensa, Josep</creatorcontrib><creatorcontrib>Soriano, Alex</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuehl, Richard</au><au>Morata, Laura</au><au>Meylan, Sylvain</au><au>Mensa, Josep</au><au>Soriano, Alex</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><stitle>J ANTIMICROB CHEMOTH</stitle><addtitle>J Antimicrob Chemother</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>75</volume><issue>5</issue><spage>1071</spage><epage>1086</epage><pages>1071-1086</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>Abstract
Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent failure of antimicrobial therapy despite susceptibility in standard microbiological assays. Bacteria capable of surviving high antibiotic concentrations despite having a genetically susceptible background are described as ‘antibiotic tolerant’. In this review, we put current knowledge on environmental triggers and molecular mechanisms of increased antibiotic survival of S. aureus into its clinical context. We discuss animal and clinical evidence of its significance and outline strategies to overcome infections with antibiotic-tolerant S. aureus.</abstract><cop>OXFORD</cop><pub>Oxford University Press</pub><pmid>32016348</pmid><doi>10.1093/jac/dkz559</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-5795-0814</orcidid><orcidid>https://orcid.org/0000-0002-9374-0811</orcidid><orcidid>https://orcid.org/0000-0002-4959-0983</orcidid></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Drug Resistance, Bacterial Humans Infectious Diseases Life Sciences & Biomedicine Microbiology Pharmacology & Pharmacy Science & Technology Staphylococcal Infections - drug therapy Staphylococcus aureus |
| title | When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus |
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