Clinical experience with daptomycin: bacteraemia and endocarditis
Serious infections due to Staphylococcus aureus, especially those due to methicillin-resistant S. aureus, have become a major challenge. Vancomycin has long been the drug of choice for treatment of such infections, but failures due to its slow bactericidal activity coupled with increasing MICs have...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2008-11, Vol.62 (suppl-3), p.iii35-iii39 |
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| container_end_page | iii39 |
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| container_issue | suppl-3 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 62 |
| creator | Levine, Donald P |
| description | Serious infections due to Staphylococcus aureus, especially those due to methicillin-resistant S. aureus, have become a major challenge. Vancomycin has long been the drug of choice for treatment of such infections, but failures due to its slow bactericidal activity coupled with increasing MICs have necessitated a search for new, more effective agents. Daptomycin has been studied by a number of investigators and has proved to be effective for bacteraemic infections due to staphylococci as well as vancomycin-resistant enterococci and other Gram-positive organisms. In addition, in a randomized controlled trial comparing daptomycin monotherapy with potentially synergistic therapy with either vancomycin or β-lactam, both used in combination with an aminoglycoside, daptomycin achieved comparable outcomes but with significantly less nephrotoxicity. |
| doi_str_mv | 10.1093/jac/dkn369 |
| format | Article |
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Vancomycin has long been the drug of choice for treatment of such infections, but failures due to its slow bactericidal activity coupled with increasing MICs have necessitated a search for new, more effective agents. Daptomycin has been studied by a number of investigators and has proved to be effective for bacteraemic infections due to staphylococci as well as vancomycin-resistant enterococci and other Gram-positive organisms. In addition, in a randomized controlled trial comparing daptomycin monotherapy with potentially synergistic therapy with either vancomycin or β-lactam, both used in combination with an aminoglycoside, daptomycin achieved comparable outcomes but with significantly less nephrotoxicity.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>18829724</pmid><doi>10.1093/jac/dkn369</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 2008-11, Vol.62 (suppl-3), p.iii35-iii39 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Anti-Bacterial Agents - therapeutic use Bacteremia - drug therapy Bacteremia - microbiology Daptomycin - therapeutic use Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - microbiology Enterococcus - drug effects Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - microbiology Humans MRSA S. aureus Staphylococcus aureus Staphylococcus aureus - drug effects Treatment Outcome |
| title | Clinical experience with daptomycin: bacteraemia and endocarditis |
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