Tyk2 is a therapeutic target for psoriasis-like skin inflammation

Tyk2 regulates IL-22/IL-23-induced psoriasis Tyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals triggered by various cytokines, which are related to the pathogenesis of psoriasis. In this study, we investigated the role of Tyk2 in IL-23-induced psoriasis-like skin inflamma...

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Veröffentlicht in:	International immunology 2014-05, Vol.26 (5), p.257-267
Hauptverfasser:	Ishizaki, Masayuki, Muromoto, Ryuta, Akimoto, Toshihiko, Sekine, Yuichi, Kon, Shigeyuki, Diwan, Manish, Maeda, Hiroaki, Togi, Sumihito, Shimoda, Kazuya, Oritani, Kenji, Matsuda, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calgranulin A - genetics Calgranulin A - immunology Cell Line Cytokines - immunology Cytokines - metabolism Defensins - genetics Defensins - immunology Enzyme Inhibitors - pharmacology Gene Expression - immunology Humans Hyperplasia - immunology Inflammation - chemically induced Inflammation - immunology Inflammation - prevention & control Inflammation Mediators - immunology Inflammation Mediators - metabolism Interleukin-17 - immunology Interleukin-17 - metabolism Interleukin-22 Interleukin-23 Interleukins - immunology Interleukins - metabolism Interleukins - pharmacology Keratinocytes - drug effects Keratinocytes - immunology Keratinocytes - metabolism Mice, Inbred BALB C Mice, Knockout Psoriasis - chemically induced Psoriasis - immunology Psoriasis - prevention & control Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction - drug effects Signal Transduction - immunology Skin - immunology Skin - metabolism Skin - pathology TYK2 Kinase - antagonists & inhibitors TYK2 Kinase - genetics TYK2 Kinase - immunology Tyrphostins - pharmacology
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