F-084PERFORMING SLEEVE LOBECTOMY INSTEAD OF PNEUMONECTOMY FOR NON-SMALL LUNG CANCER WITH N1 NODAL DISEASE DOES NOT COMPROMISE LONG-TERM SURVIVAL
Objectives N1 nodal disease may be a risk factor for developing locoregional recurrence after sleeve lobectomy for non-small cell lung cancer (NSCLC). We evaluated if sleeve lobectomy had worse survival compared to pneumonectomy for NSCLC with N1 disease involvement. Methods A retrospective review w...
Gespeichert in:
| Veröffentlicht in: | Interactive cardiovascular and thoracic surgery 2013-07, Vol.17 (suppl_1), p.S22-S23 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S23 |
|---|---|
| container_issue | suppl_1 |
| container_start_page | S22 |
| container_title | Interactive cardiovascular and thoracic surgery |
| container_volume | 17 |
| creator | Berry, Mark Worni, M. Harpole, D. D'Amico, T. Onaitis, M. |
| description | Objectives
N1 nodal disease may be a risk factor for developing locoregional recurrence after sleeve lobectomy for non-small cell lung cancer (NSCLC). We evaluated if sleeve lobectomy had worse survival compared to pneumonectomy for NSCLC with N1 disease involvement.
Methods
A retrospective review was performed of all patients with T2-3N1M0 NSCLC who underwent pneumonectomy or sleeve lobectomy at a single institution from 1999 to 2011. Survival was determined with the Kaplan-Meier method, and multivariable Cox proportional hazards regression was used to evaluate the impact of resection extent on survival.
Results
During the study period, 87 patients underwent resection for T2-3N1M0 NSCLC with pneumonectomy (n = 52, 60%) or sleeve lobectomy (n = 35, 40%). Pneumonectomy and sleeve lobectomy patients had similar mean (SD) ages (60.9 ± 10.7 vs 63.5 ± 12.7, P = 0.30), gender distribution (69.2% [36 of 52] vs 60.0% [21 of 35] male, P = 0.37), mean FEV1 (66.3 ± 15.9 vs 63.5 ± 17.6, P = 0.47), mean DLCO (70.2 ± 17.4 vs 74 ± 24.6, P = 0.11), tumour stage (61.5% [32 of 52] vs 62.9% [22 of 35] stage II, P = 0.90), and tumour grade (51.9% [27 of 52] vs 31.4% [11 of 35] well/moderately differentiated, P = 0.17), respectively. Postoperative mortality (3.9% [2 of 52] vs 5.7% [2 of 35], P = 0.68) and length of stay (5 [IQR 4-7] vs 5 [4-7] days, P = 0.68) were similar between the two groups. Three-year survival after pneumonectomy (46.8% [95% CI: 31.8-60.4%]) and sleeve lobectomy (65.2% [45.5-79.3%]) were not significantly different (P = 0.23). In multivariable survival analysis that included age, resection extent, stage, and grade, only increasing age predicted worse survival (HR 1.03/year, P = 0.03).
Conclusions
Performing sleeve lobectomy instead of pneumonectomy for NSCLC with N1 nodal disease does not compromise long-term survival.
Disclosure
All authors have declared no conflicts of interest. |
| doi_str_mv | 10.1093/icvts/ivt288.84 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_TOX</sourceid><recordid>TN_cdi_crossref_primary_10_1093_icvts_ivt288_84</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/icvts/ivt288.84</oup_id><sourcerecordid>10.1093/icvts/ivt288.84</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1164-c42c36f84301d9875536866020463b8e74090862f115dcbdc0731f969839184a3</originalsourceid><addsrcrecordid>eNqFkF9LwzAUxYMoOKfPvuZZ6JY0aZY81jbdCvkzmnbiU9myFSbKRrsN_BZ-ZKsbvvp0L-fccw_8AHjEaISRIOOtPx268fZ0CDkfcXoFBjhiIhAhj67_dkFuwV3XvSGEBSJoAL6yAHE6l0VmC52bKXRKyoWEyj7LpLT6FebGlTJOoc3g3MhKW3Mx-gQ01gROx0pBVfXhJDaJLOBLXs6gwb2bxgqmuZOxkzC10vVSCROr54XVvdzXmGlQykJDVxWLfBGre3DTLN-7zcNlDkGVyTKZBcpO8yRWgceY0cDT0BPWcEoQXgs-iSLCOGMoRJSRFd9MKBKIs7DBOFr71dqjCcGNYIITgTldkiEYn__6dtd17aap9-32Y9l-1hjVP0DrX6D1GWjdFw3B0zmxO-7_Pf4G6a5s7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>F-084PERFORMING SLEEVE LOBECTOMY INSTEAD OF PNEUMONECTOMY FOR NON-SMALL LUNG CANCER WITH N1 NODAL DISEASE DOES NOT COMPROMISE LONG-TERM SURVIVAL</title><source>Oxford Journals Open Access Collection</source><creator>Berry, Mark ; Worni, M. ; Harpole, D. ; D'Amico, T. ; Onaitis, M.</creator><creatorcontrib>Berry, Mark ; Worni, M. ; Harpole, D. ; D'Amico, T. ; Onaitis, M.</creatorcontrib><description>Objectives
N1 nodal disease may be a risk factor for developing locoregional recurrence after sleeve lobectomy for non-small cell lung cancer (NSCLC). We evaluated if sleeve lobectomy had worse survival compared to pneumonectomy for NSCLC with N1 disease involvement.
Methods
A retrospective review was performed of all patients with T2-3N1M0 NSCLC who underwent pneumonectomy or sleeve lobectomy at a single institution from 1999 to 2011. Survival was determined with the Kaplan-Meier method, and multivariable Cox proportional hazards regression was used to evaluate the impact of resection extent on survival.
Results
During the study period, 87 patients underwent resection for T2-3N1M0 NSCLC with pneumonectomy (n = 52, 60%) or sleeve lobectomy (n = 35, 40%). Pneumonectomy and sleeve lobectomy patients had similar mean (SD) ages (60.9 ± 10.7 vs 63.5 ± 12.7, P = 0.30), gender distribution (69.2% [36 of 52] vs 60.0% [21 of 35] male, P = 0.37), mean FEV1 (66.3 ± 15.9 vs 63.5 ± 17.6, P = 0.47), mean DLCO (70.2 ± 17.4 vs 74 ± 24.6, P = 0.11), tumour stage (61.5% [32 of 52] vs 62.9% [22 of 35] stage II, P = 0.90), and tumour grade (51.9% [27 of 52] vs 31.4% [11 of 35] well/moderately differentiated, P = 0.17), respectively. Postoperative mortality (3.9% [2 of 52] vs 5.7% [2 of 35], P = 0.68) and length of stay (5 [IQR 4-7] vs 5 [4-7] days, P = 0.68) were similar between the two groups. Three-year survival after pneumonectomy (46.8% [95% CI: 31.8-60.4%]) and sleeve lobectomy (65.2% [45.5-79.3%]) were not significantly different (P = 0.23). In multivariable survival analysis that included age, resection extent, stage, and grade, only increasing age predicted worse survival (HR 1.03/year, P = 0.03).
Conclusions
Performing sleeve lobectomy instead of pneumonectomy for NSCLC with N1 nodal disease does not compromise long-term survival.
Disclosure
All authors have declared no conflicts of interest.</description><identifier>ISSN: 1569-9293</identifier><identifier>EISSN: 1569-9285</identifier><identifier>DOI: 10.1093/icvts/ivt288.84</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Interactive cardiovascular and thoracic surgery, 2013-07, Vol.17 (suppl_1), p.S22-S23</ispartof><rights>The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1598,27901,27902</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/icvts/ivt288.84$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc></links><search><creatorcontrib>Berry, Mark</creatorcontrib><creatorcontrib>Worni, M.</creatorcontrib><creatorcontrib>Harpole, D.</creatorcontrib><creatorcontrib>D'Amico, T.</creatorcontrib><creatorcontrib>Onaitis, M.</creatorcontrib><title>F-084PERFORMING SLEEVE LOBECTOMY INSTEAD OF PNEUMONECTOMY FOR NON-SMALL LUNG CANCER WITH N1 NODAL DISEASE DOES NOT COMPROMISE LONG-TERM SURVIVAL</title><title>Interactive cardiovascular and thoracic surgery</title><description>Objectives
N1 nodal disease may be a risk factor for developing locoregional recurrence after sleeve lobectomy for non-small cell lung cancer (NSCLC). We evaluated if sleeve lobectomy had worse survival compared to pneumonectomy for NSCLC with N1 disease involvement.
Methods
A retrospective review was performed of all patients with T2-3N1M0 NSCLC who underwent pneumonectomy or sleeve lobectomy at a single institution from 1999 to 2011. Survival was determined with the Kaplan-Meier method, and multivariable Cox proportional hazards regression was used to evaluate the impact of resection extent on survival.
Results
During the study period, 87 patients underwent resection for T2-3N1M0 NSCLC with pneumonectomy (n = 52, 60%) or sleeve lobectomy (n = 35, 40%). Pneumonectomy and sleeve lobectomy patients had similar mean (SD) ages (60.9 ± 10.7 vs 63.5 ± 12.7, P = 0.30), gender distribution (69.2% [36 of 52] vs 60.0% [21 of 35] male, P = 0.37), mean FEV1 (66.3 ± 15.9 vs 63.5 ± 17.6, P = 0.47), mean DLCO (70.2 ± 17.4 vs 74 ± 24.6, P = 0.11), tumour stage (61.5% [32 of 52] vs 62.9% [22 of 35] stage II, P = 0.90), and tumour grade (51.9% [27 of 52] vs 31.4% [11 of 35] well/moderately differentiated, P = 0.17), respectively. Postoperative mortality (3.9% [2 of 52] vs 5.7% [2 of 35], P = 0.68) and length of stay (5 [IQR 4-7] vs 5 [4-7] days, P = 0.68) were similar between the two groups. Three-year survival after pneumonectomy (46.8% [95% CI: 31.8-60.4%]) and sleeve lobectomy (65.2% [45.5-79.3%]) were not significantly different (P = 0.23). In multivariable survival analysis that included age, resection extent, stage, and grade, only increasing age predicted worse survival (HR 1.03/year, P = 0.03).
Conclusions
Performing sleeve lobectomy instead of pneumonectomy for NSCLC with N1 nodal disease does not compromise long-term survival.
Disclosure
All authors have declared no conflicts of interest.</description><issn>1569-9293</issn><issn>1569-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkF9LwzAUxYMoOKfPvuZZ6JY0aZY81jbdCvkzmnbiU9myFSbKRrsN_BZ-ZKsbvvp0L-fccw_8AHjEaISRIOOtPx268fZ0CDkfcXoFBjhiIhAhj67_dkFuwV3XvSGEBSJoAL6yAHE6l0VmC52bKXRKyoWEyj7LpLT6FebGlTJOoc3g3MhKW3Mx-gQ01gROx0pBVfXhJDaJLOBLXs6gwb2bxgqmuZOxkzC10vVSCROr54XVvdzXmGlQykJDVxWLfBGre3DTLN-7zcNlDkGVyTKZBcpO8yRWgceY0cDT0BPWcEoQXgs-iSLCOGMoRJSRFd9MKBKIs7DBOFr71dqjCcGNYIITgTldkiEYn__6dtd17aap9-32Y9l-1hjVP0DrX6D1GWjdFw3B0zmxO-7_Pf4G6a5s7A</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Berry, Mark</creator><creator>Worni, M.</creator><creator>Harpole, D.</creator><creator>D'Amico, T.</creator><creator>Onaitis, M.</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201307</creationdate><title>F-084PERFORMING SLEEVE LOBECTOMY INSTEAD OF PNEUMONECTOMY FOR NON-SMALL LUNG CANCER WITH N1 NODAL DISEASE DOES NOT COMPROMISE LONG-TERM SURVIVAL</title><author>Berry, Mark ; Worni, M. ; Harpole, D. ; D'Amico, T. ; Onaitis, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1164-c42c36f84301d9875536866020463b8e74090862f115dcbdc0731f969839184a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berry, Mark</creatorcontrib><creatorcontrib>Worni, M.</creatorcontrib><creatorcontrib>Harpole, D.</creatorcontrib><creatorcontrib>D'Amico, T.</creatorcontrib><creatorcontrib>Onaitis, M.</creatorcontrib><collection>CrossRef</collection><jtitle>Interactive cardiovascular and thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Berry, Mark</au><au>Worni, M.</au><au>Harpole, D.</au><au>D'Amico, T.</au><au>Onaitis, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>F-084PERFORMING SLEEVE LOBECTOMY INSTEAD OF PNEUMONECTOMY FOR NON-SMALL LUNG CANCER WITH N1 NODAL DISEASE DOES NOT COMPROMISE LONG-TERM SURVIVAL</atitle><jtitle>Interactive cardiovascular and thoracic surgery</jtitle><date>2013-07</date><risdate>2013</risdate><volume>17</volume><issue>suppl_1</issue><spage>S22</spage><epage>S23</epage><pages>S22-S23</pages><issn>1569-9293</issn><eissn>1569-9285</eissn><abstract>Objectives
N1 nodal disease may be a risk factor for developing locoregional recurrence after sleeve lobectomy for non-small cell lung cancer (NSCLC). We evaluated if sleeve lobectomy had worse survival compared to pneumonectomy for NSCLC with N1 disease involvement.
Methods
A retrospective review was performed of all patients with T2-3N1M0 NSCLC who underwent pneumonectomy or sleeve lobectomy at a single institution from 1999 to 2011. Survival was determined with the Kaplan-Meier method, and multivariable Cox proportional hazards regression was used to evaluate the impact of resection extent on survival.
Results
During the study period, 87 patients underwent resection for T2-3N1M0 NSCLC with pneumonectomy (n = 52, 60%) or sleeve lobectomy (n = 35, 40%). Pneumonectomy and sleeve lobectomy patients had similar mean (SD) ages (60.9 ± 10.7 vs 63.5 ± 12.7, P = 0.30), gender distribution (69.2% [36 of 52] vs 60.0% [21 of 35] male, P = 0.37), mean FEV1 (66.3 ± 15.9 vs 63.5 ± 17.6, P = 0.47), mean DLCO (70.2 ± 17.4 vs 74 ± 24.6, P = 0.11), tumour stage (61.5% [32 of 52] vs 62.9% [22 of 35] stage II, P = 0.90), and tumour grade (51.9% [27 of 52] vs 31.4% [11 of 35] well/moderately differentiated, P = 0.17), respectively. Postoperative mortality (3.9% [2 of 52] vs 5.7% [2 of 35], P = 0.68) and length of stay (5 [IQR 4-7] vs 5 [4-7] days, P = 0.68) were similar between the two groups. Three-year survival after pneumonectomy (46.8% [95% CI: 31.8-60.4%]) and sleeve lobectomy (65.2% [45.5-79.3%]) were not significantly different (P = 0.23). In multivariable survival analysis that included age, resection extent, stage, and grade, only increasing age predicted worse survival (HR 1.03/year, P = 0.03).
Conclusions
Performing sleeve lobectomy instead of pneumonectomy for NSCLC with N1 nodal disease does not compromise long-term survival.
Disclosure
All authors have declared no conflicts of interest.</abstract><pub>Oxford University Press</pub><doi>10.1093/icvts/ivt288.84</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1569-9293 |
| ispartof | Interactive cardiovascular and thoracic surgery, 2013-07, Vol.17 (suppl_1), p.S22-S23 |
| issn | 1569-9293 1569-9285 |
| language | eng |
| recordid | cdi_crossref_primary_10_1093_icvts_ivt288_84 |
| source | Oxford Journals Open Access Collection |
| title | F-084PERFORMING SLEEVE LOBECTOMY INSTEAD OF PNEUMONECTOMY FOR NON-SMALL LUNG CANCER WITH N1 NODAL DISEASE DOES NOT COMPROMISE LONG-TERM SURVIVAL |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A27%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_TOX&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=F-084PERFORMING%20SLEEVE%20LOBECTOMY%20INSTEAD%20OF%20PNEUMONECTOMY%20FOR%20NON-SMALL%20LUNG%20CANCER%20WITH%20N1%20NODAL%20DISEASE%20DOES%20NOT%20COMPROMISE%20LONG-TERM%20SURVIVAL&rft.jtitle=Interactive%20cardiovascular%20and%20thoracic%20surgery&rft.au=Berry,%20Mark&rft.date=2013-07&rft.volume=17&rft.issue=suppl_1&rft.spage=S22&rft.epage=S23&rft.pages=S22-S23&rft.issn=1569-9293&rft.eissn=1569-9285&rft_id=info:doi/10.1093/icvts/ivt288.84&rft_dat=%3Coup_TOX%3E10.1093/icvts/ivt288.84%3C/oup_TOX%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/icvts/ivt288.84&rfr_iscdi=true |