Impact of estrogen replacement on letrozole-induced embryopathic effects

BACKGROUND The aromatase inhibitor, letrozole, exerts embryo toxic effects in rats, causing increased embryo lethality and anomalies of the axial skeleton at pharmacologically relevant doses. Letrozole acts by inhibiting estrogen biosynthesis. It may thus be feasible that estrogen deprivation is a c...

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Veröffentlicht in:	Human reproduction (Oxford) 2009-11, Vol.24 (11), p.2688-2692
Hauptverfasser:	Tiboni, G.M., Marotta, F., Castigliego, A.P., Rossi, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - drug therapy Abnormalities, Drug-Induced - prevention & control Animals Aromatase Inhibitors - toxicity Biological and medical sciences developmental toxicity Embryo, Mammalian - drug effects Estradiol - analogs & derivatives Estradiol - pharmacology estradiol cyclopentylpropionate estrogen replacement Estrogen Replacement Therapy Estrogens - biosynthesis Female Fetal Development - drug effects Fetal Diseases - chemically induced Fetal Diseases - drug therapy Fetal Diseases - prevention & control Gynecology. Andrology. Obstetrics letrozole Male Maternal Exposure Medical sciences Nitriles - toxicity rat Rats Rats, Sprague-Dawley Triazoles - toxicity
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