Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

Huntington's disease is neurodegenerative disorder caused by a polyglutamine expansion in the N-terminal region of the huntingtin protein (N17). Here, we analysed the relative contribution of each phosphorylatable residue in the N17 region (T3, S13 and S16) towards huntingtin exon 1 (HTTex1) ol...

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Veröffentlicht in:	Human molecular genetics 2017-10, Vol.26 (19), p.3763-3775
Hauptverfasser:	Branco-Santos, Joana, Herrera, Federico, Poças, Gonçalo M, Pires-Afonso, Yolanda, Giorgini, Flaviano, Domingos, Pedro M, Outeiro, Tiago F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Drosophila Exons Humans Huntingtin Protein - genetics Huntingtin Protein - metabolism Huntington Disease - enzymology Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Mutation Neurons - metabolism Neurons - pathology Phosphorylation Protein Aggregates - genetics Protein Phosphatase 1 - genetics Protein Phosphatase 1 - metabolism
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