Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in Drosophila using the automated axon quantification system, MeDUsA

Abstract Drosophila is an excellent model organism for studying human neurodegenerative diseases (NDs). However, there is still almost no experimental system that could directly observe the degeneration of neurons and automatically quantify axonal degeneration. In this study, we created MeDUsA (a ‘m...

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Veröffentlicht in:	Human molecular genetics 2023-04, Vol.32 (9), p.1524-1538
Hauptverfasser:	Nitta, Yohei, Kawai, Hiroki, Maki, Ryuto, Osaka, Jiro, Hakeda-Suzuki, Satoko, Nagai, Yoshitaka, Doubková, Karolína, Uehara, Tomoko, Watanabe, Kenji, Kosaki, Kenjiro, Suzuki, Takashi, Tavosanis, Gaia, Sugie, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Drosophila - genetics Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Humans Neurodegenerative Diseases - metabolism Neurons - metabolism
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