Structure-based mutagenic analysis of mechanism and substrate specificity in mammalian glycosyltransferases: porcine ST3Gal-I

Sialyltransferases (STs) play essential roles in signaling and in the cellular recognition processes of mammalian cells by selectively installing cell-surface sialic acids in an appropriate manner both temporally and organ-specifically. The availability of the first three-dimensional structure of a...

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Veröffentlicht in:	Glycobiology (Oxford) 2013-05, Vol.23 (5), p.536-545
Hauptverfasser:	Rakic, Bojana, Rao, Francesco V, Freimann, Karen, Wakarchuk, Warren, Strynadka, Natalie C J, Withers, Stephen G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalytic Domain Cytidine Monophosphate N-Acetylneuraminic Acid - metabolism Kinetics Molecular Sequence Data Mutation, Missense Protein Binding Sialyltransferases - chemistry Sialyltransferases - genetics Sialyltransferases - metabolism Substrate Specificity Swine
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