P699Mechanisms of action of the small conductance Ca2+-activated K+-channel modulator AP30663, a novel compound being developed for treatment of atrial fibrillation in man

Abstract Background Small conductance Ca2+-activated K+-channels (SK-channels) are a promising new atrial selective target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of SK-channels that is effective in converting vernakalant-resistant AF in tachy-paced pigs. Det...

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Veröffentlicht in:	European heart journal 2019-10, Vol.40 (Supplement_1)
Hauptverfasser:	Bomholtz, S H, Simo-Vicens, R, Abildgaard, L, Edvardsson, N G, Soerensen, U S, Grunnet, M, Diness, J G, Bentzen, B H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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