P5665The independent effect of insulin resistance on incidence of atrial fibrillation in non-diabetics

P5665The independent effect of insulin resistance on incidence of atrial fibrillation in non-diabetics

Abstract Purpose Patients with diabetes mellitus have an elevated risk of atrial fibrillation (AF). However, whether insulin resistance may elevate risk of AF incidence in non-diabetic is inconsistent. The aim of our study was to verify the association between insulin resistance and incidence of AF...

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Veröffentlicht in:European heart journal 2019-10, Vol.40 (Supplement_1)
Hauptverfasser: Park, J K, Park, J H, Lee, Y G, Shin, J H, Lim, Y H, Heo, R, Shin, J
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container_issue Supplement_1
container_start_page
container_title European heart journal
container_volume 40
creator Park, J K
Park, J H
Lee, Y G
Shin, J H
Lim, Y H
Heo, R
Shin, J
description Abstract Purpose Patients with diabetes mellitus have an elevated risk of atrial fibrillation (AF). However, whether insulin resistance may elevate risk of AF incidence in non-diabetic is inconsistent. The aim of our study was to verify the association between insulin resistance and incidence of AF in non-diabetics. Methods We evaluated population-based cohorts embedded in the Korean Genome Epidemiology Study. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin resistance (HOMA-IR). Baseline data including HOMA-IR and electrocardiography (ECG) were obtained at 2001. Subsequent biennial ECG was performed for identification of AF until 2016. Results Among the 8220 participants (46.8% male; median age 49 years), 25 participants had AF (0.3%) at baseline and 101 participants developed AF (1.2%) during follow up of 12 years. In multivariate Cox regression analysis, high HOMA-IR (≥1.4) was significantly associated with incident AF compared with low HOMA-IR (
doi_str_mv 10.1093/eurheartj/ehz746.0608
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However, whether insulin resistance may elevate risk of AF incidence in non-diabetic is inconsistent. The aim of our study was to verify the association between insulin resistance and incidence of AF in non-diabetics. Methods We evaluated population-based cohorts embedded in the Korean Genome Epidemiology Study. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin resistance (HOMA-IR). Baseline data including HOMA-IR and electrocardiography (ECG) were obtained at 2001. Subsequent biennial ECG was performed for identification of AF until 2016. Results Among the 8220 participants (46.8% male; median age 49 years), 25 participants had AF (0.3%) at baseline and 101 participants developed AF (1.2%) during follow up of 12 years. In multivariate Cox regression analysis, high HOMA-IR (≥1.4) was significantly associated with incident AF compared with low HOMA-IR (&lt;1.40) (adjusted hazard ratio [HR] 1.9, 95% confidence interval [CI] 1.3–3.0). In subgroup analysis, these association was consistent regardless of obesity (BMI&lt;25; adjust HR 1.8, 95% CI 1.1–3.0, BMI≥25; adjust HR 2.3, 95% CI 1.3–4.0) Subgroup analysis Conclusion Based on prospective cohort study, insulin resistance (HOMA-IR) was associated with AF independently of obesity in non-diabetics.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz746.0608</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2019-10, Vol.40 (Supplement_1)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. 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However, whether insulin resistance may elevate risk of AF incidence in non-diabetic is inconsistent. The aim of our study was to verify the association between insulin resistance and incidence of AF in non-diabetics. Methods We evaluated population-based cohorts embedded in the Korean Genome Epidemiology Study. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin resistance (HOMA-IR). Baseline data including HOMA-IR and electrocardiography (ECG) were obtained at 2001. Subsequent biennial ECG was performed for identification of AF until 2016. Results Among the 8220 participants (46.8% male; median age 49 years), 25 participants had AF (0.3%) at baseline and 101 participants developed AF (1.2%) during follow up of 12 years. In multivariate Cox regression analysis, high HOMA-IR (≥1.4) was significantly associated with incident AF compared with low HOMA-IR (&lt;1.40) (adjusted hazard ratio [HR] 1.9, 95% confidence interval [CI] 1.3–3.0). In subgroup analysis, these association was consistent regardless of obesity (BMI&lt;25; adjust HR 1.8, 95% CI 1.1–3.0, BMI≥25; adjust HR 2.3, 95% CI 1.3–4.0) Subgroup analysis Conclusion Based on prospective cohort study, insulin resistance (HOMA-IR) was associated with AF independently of obesity in non-diabetics.</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkE1LAzEQhoMoWKs_Qcgf2DbZNJPdoxS_oKCHCt6WZHZCU9bdkmQP-uvdWvHsZYZ5eZ85PIzdSrGQolZLGuOObMz7Je2-zAoWAkR1xmZSl2VRw0qfs5mQtS4AqvdLdpXSXghRgYQZ868aQG93xEPf0oGm0WdO3hNmPvgpTWMXeh4phZRtj8SHfkoxTMXj4bnNMdiO--Bi6Dqbw0-B90NftME6ygHTNbvwtkt087vn7O3hfrt-KjYvj8_ru02BUtVVIaU2CktTak3GCHCwalEZqwBL4RQCKOFKRG9achKwRaqMhFoiybpySs2ZPv3FOKQUyTeHGD5s_GykaI6ymj9ZzUlWc5Q1ceLEDePhn8g36a9zCg</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Park, J K</creator><creator>Park, J H</creator><creator>Lee, Y G</creator><creator>Shin, J H</creator><creator>Lim, Y H</creator><creator>Heo, R</creator><creator>Shin, J</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20191001</creationdate><title>P5665The independent effect of insulin resistance on incidence of atrial fibrillation in non-diabetics</title><author>Park, J K ; Park, J H ; Lee, Y G ; Shin, J H ; Lim, Y H ; Heo, R ; Shin, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1398-11573c27255e7706b64dc37a36c20b3c6630b2ccf7deb16cdce871691ce198b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, J K</creatorcontrib><creatorcontrib>Park, J H</creatorcontrib><creatorcontrib>Lee, Y G</creatorcontrib><creatorcontrib>Shin, J H</creatorcontrib><creatorcontrib>Lim, Y H</creatorcontrib><creatorcontrib>Heo, R</creatorcontrib><creatorcontrib>Shin, J</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, J K</au><au>Park, J H</au><au>Lee, Y G</au><au>Shin, J H</au><au>Lim, Y H</au><au>Heo, R</au><au>Shin, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P5665The independent effect of insulin resistance on incidence of atrial fibrillation in non-diabetics</atitle><jtitle>European heart journal</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>40</volume><issue>Supplement_1</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract Purpose Patients with diabetes mellitus have an elevated risk of atrial fibrillation (AF). However, whether insulin resistance may elevate risk of AF incidence in non-diabetic is inconsistent. The aim of our study was to verify the association between insulin resistance and incidence of AF in non-diabetics. Methods We evaluated population-based cohorts embedded in the Korean Genome Epidemiology Study. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin resistance (HOMA-IR). Baseline data including HOMA-IR and electrocardiography (ECG) were obtained at 2001. Subsequent biennial ECG was performed for identification of AF until 2016. Results Among the 8220 participants (46.8% male; median age 49 years), 25 participants had AF (0.3%) at baseline and 101 participants developed AF (1.2%) during follow up of 12 years. In multivariate Cox regression analysis, high HOMA-IR (≥1.4) was significantly associated with incident AF compared with low HOMA-IR (&lt;1.40) (adjusted hazard ratio [HR] 1.9, 95% confidence interval [CI] 1.3–3.0). In subgroup analysis, these association was consistent regardless of obesity (BMI&lt;25; adjust HR 1.8, 95% CI 1.1–3.0, BMI≥25; adjust HR 2.3, 95% CI 1.3–4.0) Subgroup analysis Conclusion Based on prospective cohort study, insulin resistance (HOMA-IR) was associated with AF independently of obesity in non-diabetics.</abstract><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehz746.0608</doi></addata></record>
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title P5665The independent effect of insulin resistance on incidence of atrial fibrillation in non-diabetics
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