P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study

P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study

Abstract Background Higher cardiac left ventricular (LV) mass (LVM) has independently been associated with cardiovascular risk and mortality. Changes in LV structure have been observed in children with obesity. However, information about the long-term influence of early growth on LV structure is lim...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European heart journal 2019-10, Vol.40 (Supplement_1)
Hauptverfasser: Korpela, N, Kaikkonen, K, Auvinen, J, Tulppo, M P, Junttila, J, Perkiomaki, J, Jarvelin, M.-R, Huikuri, H V, Kiviniemi, A M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue Supplement_1
container_start_page
container_title European heart journal
container_volume 40
creator Korpela, N
Kaikkonen, K
Auvinen, J
Tulppo, M P
Junttila, J
Perkiomaki, J
Jarvelin, M.-R
Huikuri, H V
Kiviniemi, A M
description Abstract Background Higher cardiac left ventricular (LV) mass (LVM) has independently been associated with cardiovascular risk and mortality. Changes in LV structure have been observed in children with obesity. However, information about the long-term influence of early growth on LV structure is limited. Purpose To explore the associations between early growth patterns, specifically birth weight, age and body mass index (BMI) at infant BMI peak and at childhood BMI rebound, and LV structure at midlife. Methods At the age of 46, a sample of the participants of the Northern Finland Birth Cohort 1966 took part in follow-up examinations. A randomly selected subpopulation was enrolled to echocardiographic examinations (n=1124). BMI at various ages in childhood was calculated from frequent anthropometric measurements collected from child welfare clinical records. Age and BMI at BMI peak (n=541, mean age 9.0 months) and at BMI rebound (n=657, mean age 5.8 years) were derived from random effect models. Results Birth weight (n=1124), BMI at BMI peak and at BMI rebound were directly associated with LVM (beta [standardized]: 0.171, 0.186 and 0.223, respectively, p
doi_str_mv 10.1093/eurheartj/ehz746.0286
format Article
fullrecord <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_eurheartj_ehz746_0286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehz746.0286</oup_id><sourcerecordid>10.1093/eurheartj/ehz746.0286</sourcerecordid><originalsourceid>FETCH-LOGICAL-c876-c4bee6d749755234cdcbe38dd1b9a443ef99d0134c11bd228f7e3e521c61caad3</originalsourceid><addsrcrecordid>eNqNkN9KwzAchYMoOKePIOQB7JY0f9p4p8OpICq4C-9Kmvy6ZHTtSFPHvPHV7Zx47dW5OHznwIfQJSUTShSbQh8c6BBXU3CfGZcTkubyCI2oSNNESS6O0YhQJRIp8_dTdNZ1K0JILqkcoa9Xwai89SG6Lfili1fYOF9b17YWL0O7jQ5vdIwQmg7rxuIaqog_oInBm77WAXcx9Cb2AbCOeO1t7Su4xs_tsDhAeO6bes9RJSX--cGz1g0tfou93Z2jk0rXHVz85hgt5neL2UPy9HL_OLt5SkyeycTwEkDajKtMiJRxY00JLLeWlkpzzqBSyhI6FJSWNk3zKgMGIqVGUqO1ZWMkDrMmtF0XoCo2wa912BWUFHuJxZ_E4iCx2EscOHLg2n7zT-QbFy18hw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study</title><source>OUP_牛津大学出版社现刊</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Korpela, N ; Kaikkonen, K ; Auvinen, J ; Tulppo, M P ; Junttila, J ; Perkiomaki, J ; Jarvelin, M.-R ; Huikuri, H V ; Kiviniemi, A M</creator><creatorcontrib>Korpela, N ; Kaikkonen, K ; Auvinen, J ; Tulppo, M P ; Junttila, J ; Perkiomaki, J ; Jarvelin, M.-R ; Huikuri, H V ; Kiviniemi, A M</creatorcontrib><description>Abstract Background Higher cardiac left ventricular (LV) mass (LVM) has independently been associated with cardiovascular risk and mortality. Changes in LV structure have been observed in children with obesity. However, information about the long-term influence of early growth on LV structure is limited. Purpose To explore the associations between early growth patterns, specifically birth weight, age and body mass index (BMI) at infant BMI peak and at childhood BMI rebound, and LV structure at midlife. Methods At the age of 46, a sample of the participants of the Northern Finland Birth Cohort 1966 took part in follow-up examinations. A randomly selected subpopulation was enrolled to echocardiographic examinations (n=1124). BMI at various ages in childhood was calculated from frequent anthropometric measurements collected from child welfare clinical records. Age and BMI at BMI peak (n=541, mean age 9.0 months) and at BMI rebound (n=657, mean age 5.8 years) were derived from random effect models. Results Birth weight (n=1124), BMI at BMI peak and at BMI rebound were directly associated with LVM (beta [standardized]: 0.171, 0.186 and 0.223, respectively, p&lt;0.001 for all) and LVM index (LVMI) (beta: 0.146, 0.120 and 0.120, respectively, p&lt;0.01 for all) at midlife. All the associations, except that between BMI at BMI peak and LVMI, remained significant after adjustments for gender, adult blood pressure, heart rate, antihypertensive medications, heart diseases and diabetes (p&lt;0.05 for all). Significant interaction between gender and age at BMI rebound was observed in LVMI. Age at BMI rebound was inversely associated with LVMI in both genders, the association being stronger in males (beta: −0.212, p&lt;0.001) compared to females (beta: −0.117, p=0.025) and independent of potential confounders. There were direct univariate associations of birth weight and BMI at BMI peak and rebound with LV relative wall thickness (p=0.009–0.019), which were largely explained by potential confounders. However, the association of birth weight with LV relative wall thickness retained its significance even after relevant adjustments (beta: 0.097, p=0.001). After additional adjustments for adult BMI, only associations of birth weight and BMI at BMI peak with LVM remained significant, which, however, did not remain significant after additional adjustment for adult height. Conclusions This study shows that birth weight and early growth patterns are associated with LV structure at midlife, which is largely explained by adult BMI. Therefore, the relationship between early growth patterns to LV structure in the adulthood may be largely explained by their strong tracking to obesity and related cardiovascular risk factors at midlife and to some extent by normal somatic growth.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz746.0286</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2019-10, Vol.40 (Supplement_1)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids></links><search><creatorcontrib>Korpela, N</creatorcontrib><creatorcontrib>Kaikkonen, K</creatorcontrib><creatorcontrib>Auvinen, J</creatorcontrib><creatorcontrib>Tulppo, M P</creatorcontrib><creatorcontrib>Junttila, J</creatorcontrib><creatorcontrib>Perkiomaki, J</creatorcontrib><creatorcontrib>Jarvelin, M.-R</creatorcontrib><creatorcontrib>Huikuri, H V</creatorcontrib><creatorcontrib>Kiviniemi, A M</creatorcontrib><title>P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study</title><title>European heart journal</title><description>Abstract Background Higher cardiac left ventricular (LV) mass (LVM) has independently been associated with cardiovascular risk and mortality. Changes in LV structure have been observed in children with obesity. However, information about the long-term influence of early growth on LV structure is limited. Purpose To explore the associations between early growth patterns, specifically birth weight, age and body mass index (BMI) at infant BMI peak and at childhood BMI rebound, and LV structure at midlife. Methods At the age of 46, a sample of the participants of the Northern Finland Birth Cohort 1966 took part in follow-up examinations. A randomly selected subpopulation was enrolled to echocardiographic examinations (n=1124). BMI at various ages in childhood was calculated from frequent anthropometric measurements collected from child welfare clinical records. Age and BMI at BMI peak (n=541, mean age 9.0 months) and at BMI rebound (n=657, mean age 5.8 years) were derived from random effect models. Results Birth weight (n=1124), BMI at BMI peak and at BMI rebound were directly associated with LVM (beta [standardized]: 0.171, 0.186 and 0.223, respectively, p&lt;0.001 for all) and LVM index (LVMI) (beta: 0.146, 0.120 and 0.120, respectively, p&lt;0.01 for all) at midlife. All the associations, except that between BMI at BMI peak and LVMI, remained significant after adjustments for gender, adult blood pressure, heart rate, antihypertensive medications, heart diseases and diabetes (p&lt;0.05 for all). Significant interaction between gender and age at BMI rebound was observed in LVMI. Age at BMI rebound was inversely associated with LVMI in both genders, the association being stronger in males (beta: −0.212, p&lt;0.001) compared to females (beta: −0.117, p=0.025) and independent of potential confounders. There were direct univariate associations of birth weight and BMI at BMI peak and rebound with LV relative wall thickness (p=0.009–0.019), which were largely explained by potential confounders. However, the association of birth weight with LV relative wall thickness retained its significance even after relevant adjustments (beta: 0.097, p=0.001). After additional adjustments for adult BMI, only associations of birth weight and BMI at BMI peak with LVM remained significant, which, however, did not remain significant after additional adjustment for adult height. Conclusions This study shows that birth weight and early growth patterns are associated with LV structure at midlife, which is largely explained by adult BMI. Therefore, the relationship between early growth patterns to LV structure in the adulthood may be largely explained by their strong tracking to obesity and related cardiovascular risk factors at midlife and to some extent by normal somatic growth.</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkN9KwzAchYMoOKePIOQB7JY0f9p4p8OpICq4C-9Kmvy6ZHTtSFPHvPHV7Zx47dW5OHznwIfQJSUTShSbQh8c6BBXU3CfGZcTkubyCI2oSNNESS6O0YhQJRIp8_dTdNZ1K0JILqkcoa9Xwai89SG6Lfili1fYOF9b17YWL0O7jQ5vdIwQmg7rxuIaqog_oInBm77WAXcx9Cb2AbCOeO1t7Su4xs_tsDhAeO6bes9RJSX--cGz1g0tfou93Z2jk0rXHVz85hgt5neL2UPy9HL_OLt5SkyeycTwEkDajKtMiJRxY00JLLeWlkpzzqBSyhI6FJSWNk3zKgMGIqVGUqO1ZWMkDrMmtF0XoCo2wa912BWUFHuJxZ_E4iCx2EscOHLg2n7zT-QbFy18hw</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Korpela, N</creator><creator>Kaikkonen, K</creator><creator>Auvinen, J</creator><creator>Tulppo, M P</creator><creator>Junttila, J</creator><creator>Perkiomaki, J</creator><creator>Jarvelin, M.-R</creator><creator>Huikuri, H V</creator><creator>Kiviniemi, A M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20191001</creationdate><title>P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study</title><author>Korpela, N ; Kaikkonen, K ; Auvinen, J ; Tulppo, M P ; Junttila, J ; Perkiomaki, J ; Jarvelin, M.-R ; Huikuri, H V ; Kiviniemi, A M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c876-c4bee6d749755234cdcbe38dd1b9a443ef99d0134c11bd228f7e3e521c61caad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korpela, N</creatorcontrib><creatorcontrib>Kaikkonen, K</creatorcontrib><creatorcontrib>Auvinen, J</creatorcontrib><creatorcontrib>Tulppo, M P</creatorcontrib><creatorcontrib>Junttila, J</creatorcontrib><creatorcontrib>Perkiomaki, J</creatorcontrib><creatorcontrib>Jarvelin, M.-R</creatorcontrib><creatorcontrib>Huikuri, H V</creatorcontrib><creatorcontrib>Kiviniemi, A M</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korpela, N</au><au>Kaikkonen, K</au><au>Auvinen, J</au><au>Tulppo, M P</au><au>Junttila, J</au><au>Perkiomaki, J</au><au>Jarvelin, M.-R</au><au>Huikuri, H V</au><au>Kiviniemi, A M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study</atitle><jtitle>European heart journal</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>40</volume><issue>Supplement_1</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract Background Higher cardiac left ventricular (LV) mass (LVM) has independently been associated with cardiovascular risk and mortality. Changes in LV structure have been observed in children with obesity. However, information about the long-term influence of early growth on LV structure is limited. Purpose To explore the associations between early growth patterns, specifically birth weight, age and body mass index (BMI) at infant BMI peak and at childhood BMI rebound, and LV structure at midlife. Methods At the age of 46, a sample of the participants of the Northern Finland Birth Cohort 1966 took part in follow-up examinations. A randomly selected subpopulation was enrolled to echocardiographic examinations (n=1124). BMI at various ages in childhood was calculated from frequent anthropometric measurements collected from child welfare clinical records. Age and BMI at BMI peak (n=541, mean age 9.0 months) and at BMI rebound (n=657, mean age 5.8 years) were derived from random effect models. Results Birth weight (n=1124), BMI at BMI peak and at BMI rebound were directly associated with LVM (beta [standardized]: 0.171, 0.186 and 0.223, respectively, p&lt;0.001 for all) and LVM index (LVMI) (beta: 0.146, 0.120 and 0.120, respectively, p&lt;0.01 for all) at midlife. All the associations, except that between BMI at BMI peak and LVMI, remained significant after adjustments for gender, adult blood pressure, heart rate, antihypertensive medications, heart diseases and diabetes (p&lt;0.05 for all). Significant interaction between gender and age at BMI rebound was observed in LVMI. Age at BMI rebound was inversely associated with LVMI in both genders, the association being stronger in males (beta: −0.212, p&lt;0.001) compared to females (beta: −0.117, p=0.025) and independent of potential confounders. There were direct univariate associations of birth weight and BMI at BMI peak and rebound with LV relative wall thickness (p=0.009–0.019), which were largely explained by potential confounders. However, the association of birth weight with LV relative wall thickness retained its significance even after relevant adjustments (beta: 0.097, p=0.001). After additional adjustments for adult BMI, only associations of birth weight and BMI at BMI peak with LVM remained significant, which, however, did not remain significant after additional adjustment for adult height. Conclusions This study shows that birth weight and early growth patterns are associated with LV structure at midlife, which is largely explained by adult BMI. Therefore, the relationship between early growth patterns to LV structure in the adulthood may be largely explained by their strong tracking to obesity and related cardiovascular risk factors at midlife and to some extent by normal somatic growth.</abstract><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehz746.0286</doi></addata></record>
fulltext fulltext
identifier ISSN: 0195-668X
ispartof European heart journal, 2019-10, Vol.40 (Supplement_1)
issn 0195-668X
1522-9645
language eng
recordid cdi_crossref_primary_10_1093_eurheartj_ehz746_0286
source OUP_牛津大学出版社现刊; Alma/SFX Local Collection; EZB Electronic Journals Library
title P5316Birthweight, childhood growth patterns and left ventricular structure at midlife: Northern Finland 1966 Birth Cohort Study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T15%3A09%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=P5316Birthweight,%20childhood%20growth%20patterns%20and%20left%20ventricular%20structure%20at%20midlife:%20Northern%20Finland%201966%20Birth%20Cohort%20Study&rft.jtitle=European%20heart%20journal&rft.au=Korpela,%20N&rft.date=2019-10-01&rft.volume=40&rft.issue=Supplement_1&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/eurheartj/ehz746.0286&rft_dat=%3Coup_cross%3E10.1093/eurheartj/ehz746.0286%3C/oup_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/eurheartj/ehz746.0286&rfr_iscdi=true