P3696Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: an echocardiographic and computed tomography study
Abstract Background Acceleration time to ejection time ratio (AT/ET) prolongation is associated with increased mortality in patients with aortic stenosis (AS). Purpose To identify the determinants associated with increased AT/ET. Methods The relationships between AT/ET ratio, clinical and Doppler ec...
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| Veröffentlicht in: | European heart journal 2019-10, Vol.40 (Supplement_1) |
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| creator | Altes, A Sochala, M Attias, D Dreyfus, J Toledano, M Macron, L Renard, C Truffier, A Guerbaai, R A Ennezat, P V Graux, P Tribouilloy, C Marechaux, S |
| description | Abstract
Background
Acceleration time to ejection time ratio (AT/ET) prolongation is associated with increased mortality in patients with aortic stenosis (AS).
Purpose
To identify the determinants associated with increased AT/ET.
Methods
The relationships between AT/ET ratio, clinical and Doppler echocardiographic variables of interest in the setting of AS were studied in 1107 patients with AS and preserved left ventricular (LV) ejection fraction (EF), with Computed Tomography – Aortic Valve Calcium (CT-AVC) score studied in a subgroup of 342 patients.
Results
In univariate analysis, AT/ET ratio did correlate with aortic peak velocity (Vmax, r=0.57, p |
| doi_str_mv | 10.1093/eurheartj/ehz745.0550 |
| format | Article |
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Background
Acceleration time to ejection time ratio (AT/ET) prolongation is associated with increased mortality in patients with aortic stenosis (AS).
Purpose
To identify the determinants associated with increased AT/ET.
Methods
The relationships between AT/ET ratio, clinical and Doppler echocardiographic variables of interest in the setting of AS were studied in 1107 patients with AS and preserved left ventricular (LV) ejection fraction (EF), with Computed Tomography – Aortic Valve Calcium (CT-AVC) score studied in a subgroup of 342 patients.
Results
In univariate analysis, AT/ET ratio did correlate with aortic peak velocity (Vmax, r=0.57, p<0.0001), mean pressure gradient (MPG, r=0.60, p<0.0001), aortic valve area (AVA, r=−0.50, p<0.0001) and CT-AVC score (r=0.24, p<0.0001). An AT/ET ratio had a good accuracy to predict an aortic peak velocity ≥4 m/s, a MPG≥40 mmHg, or an AVA≤1.0 cm2, with an optimal cut-off value of 0.34. By multivariate linear regression analysis, presence of AS-related symptoms, decreased LV stroke volume index, LVEF, systolic blood pressure (SBP), absence of diabetes mellitus, and increased LV mass index, relative wall thickness, and Vmax were independently associated with increased AT/ET ratio (all P<0.05). In the subgroup of patients who underwent CT-AVC, CT-AVC score was independently associated with increased AT/ET ratio (P<0.05).
Conclusion
AT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond hemodynamic and anatomic severity of AS influence AT/ET ratio including LV geometry, function and SBP. These findings should be considered when assessing AT/ET in patients with AS and preserved LVEF.
Acknowledgement/Funding
Local funding]]></description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz745.0550</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2019-10, Vol.40 (Supplement_1)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Altes, A</creatorcontrib><creatorcontrib>Sochala, M</creatorcontrib><creatorcontrib>Attias, D</creatorcontrib><creatorcontrib>Dreyfus, J</creatorcontrib><creatorcontrib>Toledano, M</creatorcontrib><creatorcontrib>Macron, L</creatorcontrib><creatorcontrib>Renard, C</creatorcontrib><creatorcontrib>Truffier, A</creatorcontrib><creatorcontrib>Guerbaai, R A</creatorcontrib><creatorcontrib>Ennezat, P V</creatorcontrib><creatorcontrib>Graux, P</creatorcontrib><creatorcontrib>Tribouilloy, C</creatorcontrib><creatorcontrib>Marechaux, S</creatorcontrib><title>P3696Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: an echocardiographic and computed tomography study</title><title>European heart journal</title><description><![CDATA[Abstract
Background
Acceleration time to ejection time ratio (AT/ET) prolongation is associated with increased mortality in patients with aortic stenosis (AS).
Purpose
To identify the determinants associated with increased AT/ET.
Methods
The relationships between AT/ET ratio, clinical and Doppler echocardiographic variables of interest in the setting of AS were studied in 1107 patients with AS and preserved left ventricular (LV) ejection fraction (EF), with Computed Tomography – Aortic Valve Calcium (CT-AVC) score studied in a subgroup of 342 patients.
Results
In univariate analysis, AT/ET ratio did correlate with aortic peak velocity (Vmax, r=0.57, p<0.0001), mean pressure gradient (MPG, r=0.60, p<0.0001), aortic valve area (AVA, r=−0.50, p<0.0001) and CT-AVC score (r=0.24, p<0.0001). An AT/ET ratio had a good accuracy to predict an aortic peak velocity ≥4 m/s, a MPG≥40 mmHg, or an AVA≤1.0 cm2, with an optimal cut-off value of 0.34. By multivariate linear regression analysis, presence of AS-related symptoms, decreased LV stroke volume index, LVEF, systolic blood pressure (SBP), absence of diabetes mellitus, and increased LV mass index, relative wall thickness, and Vmax were independently associated with increased AT/ET ratio (all P<0.05). In the subgroup of patients who underwent CT-AVC, CT-AVC score was independently associated with increased AT/ET ratio (P<0.05).
Conclusion
AT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond hemodynamic and anatomic severity of AS influence AT/ET ratio including LV geometry, function and SBP. These findings should be considered when assessing AT/ET in patients with AS and preserved LVEF.
Acknowledgement/Funding
Local funding]]></description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkM9KxDAQh4MouK4-gpAX6O6kbbKNN1n8Bwt62IO3kqYTm2XblCRF1hfxde1a0aun4Tc_voH5CLlmsGAgsyUOvkHl426Jzccq5wvgHE7IjPE0TaTI-SmZAZM8EaJ4PScXIewAoBBMzMjnSyakWDvvca8iBuoMjQ1Sr6J1x6C0xj1-x45G2yKNjuIO9d_CdrQfe-xioO82NlQ5H62mIWLngg03VHUUdeO08rV1b171zVirrqbatf0QsR6PtlNxGLGhPlySM6P2Aa9-5pxs7--268dk8_zwtL7dJLpYQWLSfPwP0pQVLK9qprhOIVtJwYBlqhamQCORS-BZBcLkwlSpVBLSTCghKpnNCZ_Oau9C8GjK3ttW-UPJoDzKLX_llpPc8ih35GDi3ND_E_kCiZuEvw</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Altes, A</creator><creator>Sochala, M</creator><creator>Attias, D</creator><creator>Dreyfus, J</creator><creator>Toledano, M</creator><creator>Macron, L</creator><creator>Renard, C</creator><creator>Truffier, A</creator><creator>Guerbaai, R A</creator><creator>Ennezat, P V</creator><creator>Graux, P</creator><creator>Tribouilloy, C</creator><creator>Marechaux, S</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20191001</creationdate><title>P3696Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: an echocardiographic and computed tomography study</title><author>Altes, A ; Sochala, M ; Attias, D ; Dreyfus, J ; Toledano, M ; Macron, L ; Renard, C ; Truffier, A ; Guerbaai, R A ; Ennezat, P V ; Graux, P ; Tribouilloy, C ; Marechaux, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c870-f249640221814bd1a5c2037961013ad6f8ef9e59053b06f46fb29a90236a66b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altes, A</creatorcontrib><creatorcontrib>Sochala, M</creatorcontrib><creatorcontrib>Attias, D</creatorcontrib><creatorcontrib>Dreyfus, J</creatorcontrib><creatorcontrib>Toledano, M</creatorcontrib><creatorcontrib>Macron, L</creatorcontrib><creatorcontrib>Renard, C</creatorcontrib><creatorcontrib>Truffier, A</creatorcontrib><creatorcontrib>Guerbaai, R A</creatorcontrib><creatorcontrib>Ennezat, P V</creatorcontrib><creatorcontrib>Graux, P</creatorcontrib><creatorcontrib>Tribouilloy, C</creatorcontrib><creatorcontrib>Marechaux, S</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altes, A</au><au>Sochala, M</au><au>Attias, D</au><au>Dreyfus, J</au><au>Toledano, M</au><au>Macron, L</au><au>Renard, C</au><au>Truffier, A</au><au>Guerbaai, R A</au><au>Ennezat, P V</au><au>Graux, P</au><au>Tribouilloy, C</au><au>Marechaux, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P3696Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: an echocardiographic and computed tomography study</atitle><jtitle>European heart journal</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>40</volume><issue>Supplement_1</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract><![CDATA[Abstract
Background
Acceleration time to ejection time ratio (AT/ET) prolongation is associated with increased mortality in patients with aortic stenosis (AS).
Purpose
To identify the determinants associated with increased AT/ET.
Methods
The relationships between AT/ET ratio, clinical and Doppler echocardiographic variables of interest in the setting of AS were studied in 1107 patients with AS and preserved left ventricular (LV) ejection fraction (EF), with Computed Tomography – Aortic Valve Calcium (CT-AVC) score studied in a subgroup of 342 patients.
Results
In univariate analysis, AT/ET ratio did correlate with aortic peak velocity (Vmax, r=0.57, p<0.0001), mean pressure gradient (MPG, r=0.60, p<0.0001), aortic valve area (AVA, r=−0.50, p<0.0001) and CT-AVC score (r=0.24, p<0.0001). An AT/ET ratio had a good accuracy to predict an aortic peak velocity ≥4 m/s, a MPG≥40 mmHg, or an AVA≤1.0 cm2, with an optimal cut-off value of 0.34. By multivariate linear regression analysis, presence of AS-related symptoms, decreased LV stroke volume index, LVEF, systolic blood pressure (SBP), absence of diabetes mellitus, and increased LV mass index, relative wall thickness, and Vmax were independently associated with increased AT/ET ratio (all P<0.05). In the subgroup of patients who underwent CT-AVC, CT-AVC score was independently associated with increased AT/ET ratio (P<0.05).
Conclusion
AT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond hemodynamic and anatomic severity of AS influence AT/ET ratio including LV geometry, function and SBP. These findings should be considered when assessing AT/ET in patients with AS and preserved LVEF.
Acknowledgement/Funding
Local funding]]></abstract><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehz745.0550</doi></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | P3696Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: an echocardiographic and computed tomography study |
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