P3139Transvenous lead extraction: lead age threshold to predict the success of the procedure
Abstract Introduction Transvenous lead extraction is a safe and effective procedure. The dwell time of the leads, with other factors, is associated with poor outcome of the procedure. However, a precise estimation of the success of the procedure is not available. Purpose The aim of this study is to...
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| Veröffentlicht in: | European heart journal 2019-10, Vol.40 (Supplement_1) |
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| creator | Giannotti Santoro, M Segreti, L Fiorentini, F Bernini, G Barletta, V Della Tommasina, V Cellamaro, T Soldati, E Di Cori, A Zucchelli, G De Lucia, R Viani, S Paperini, L Pedrinelli, R Bongiorni, M G |
| description | Abstract
Introduction
Transvenous lead extraction is a safe and effective procedure. The dwell time of the leads, with other factors, is associated with poor outcome of the procedure. However, a precise estimation of the success of the procedure is not available.
Purpose
The aim of this study is to identify a lead's age threshold able to predict the success of the transvenous lead extraction (TLE) procedure.
Methods
All patients who underwent TLE in our center from January 2009 to December 2017 were retrospectively analyzed. The primary endpoint was the clinical success of the procedure. The optimal cut-off threshold was determined by the analysis of Receiver-Operating Characteristics (ROC) curves, using the Youden index.
Results
We analyzed 1210 consecutive patients that required transvenous removal of 2343 leads (686 ICD leads, 1657 pacemaker leads, 322 coronary sinus leads). Clinical success was achieved in 1168 patients (96.5%). Dwelling time median of the oldest lead for a patient was 66 months (interquartile range 27.0–115.0). The oldest lead completely removed was 32 years old. ROC curve analysis showed a dwell time threshold of 107 months – 8,92 years - for clinical success (Positive Predictive Value: 99.5%; Negative Predictive Value: 7.8%) and the area under the curve (AUC) was 0.879. Comparison of ROC for dwelling time and the 0.5 curve was assessed as statistically significative (p |
| doi_str_mv | 10.1093/eurheartj/ehz745.0214 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_eurheartj_ehz745_0214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehz745.0214</oup_id><sourcerecordid>10.1093/eurheartj/ehz745.0214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c874-6248bb235154810ae10fb0771593e22ce7cb204efc82b40768dacfe40b3b866a3</originalsourceid><addsrcrecordid>eNqNkMtKw0AYhQdRsFYfQZgXSPvPNRN3UrxBQRdZuBDCzOSPSamdMJOI-vS2Rly7OpwD31l8hFwyWDAoxBLH2KKNw2aJ7Vcu1QI4k0dkxhTnWaGlOiYzYIXKtDbPp-QspQ0AGM30jLw8CSaKMtpdesddGBPdoq0pfgzR-qELu6tpsK9IhzZiasO2pkOgfcS688N-RJpG7zElGpqf2sfgsR4jnpOTxm4TXvzmnJS3N-XqPls_3j2srteZN7nMNJfGOS4UU9IwsMigcZDnTBUCOfeYe8dBYuMNdxJybWrrG5TghDNaWzEnarr1MaQUsan62L3Z-FkxqA6Gqj9D1WSoOhjaczBxYez_iXwDXHdu5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>P3139Transvenous lead extraction: lead age threshold to predict the success of the procedure</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Giannotti Santoro, M ; Segreti, L ; Fiorentini, F ; Bernini, G ; Barletta, V ; Della Tommasina, V ; Cellamaro, T ; Soldati, E ; Di Cori, A ; Zucchelli, G ; De Lucia, R ; Viani, S ; Paperini, L ; Pedrinelli, R ; Bongiorni, M G</creator><creatorcontrib>Giannotti Santoro, M ; Segreti, L ; Fiorentini, F ; Bernini, G ; Barletta, V ; Della Tommasina, V ; Cellamaro, T ; Soldati, E ; Di Cori, A ; Zucchelli, G ; De Lucia, R ; Viani, S ; Paperini, L ; Pedrinelli, R ; Bongiorni, M G</creatorcontrib><description>Abstract
Introduction
Transvenous lead extraction is a safe and effective procedure. The dwell time of the leads, with other factors, is associated with poor outcome of the procedure. However, a precise estimation of the success of the procedure is not available.
Purpose
The aim of this study is to identify a lead's age threshold able to predict the success of the transvenous lead extraction (TLE) procedure.
Methods
All patients who underwent TLE in our center from January 2009 to December 2017 were retrospectively analyzed. The primary endpoint was the clinical success of the procedure. The optimal cut-off threshold was determined by the analysis of Receiver-Operating Characteristics (ROC) curves, using the Youden index.
Results
We analyzed 1210 consecutive patients that required transvenous removal of 2343 leads (686 ICD leads, 1657 pacemaker leads, 322 coronary sinus leads). Clinical success was achieved in 1168 patients (96.5%). Dwelling time median of the oldest lead for a patient was 66 months (interquartile range 27.0–115.0). The oldest lead completely removed was 32 years old. ROC curve analysis showed a dwell time threshold of 107 months – 8,92 years - for clinical success (Positive Predictive Value: 99.5%; Negative Predictive Value: 7.8%) and the area under the curve (AUC) was 0.879. Comparison of ROC for dwelling time and the 0.5 curve was assessed as statistically significative (p<0.0001).
Conclusions
Transvenous lead extraction is an effective procedure. The best cut-off threshold to predict a very high clinical success is 107 months.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz745.0214</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2019-10, Vol.40 (Supplement_1)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Giannotti Santoro, M</creatorcontrib><creatorcontrib>Segreti, L</creatorcontrib><creatorcontrib>Fiorentini, F</creatorcontrib><creatorcontrib>Bernini, G</creatorcontrib><creatorcontrib>Barletta, V</creatorcontrib><creatorcontrib>Della Tommasina, V</creatorcontrib><creatorcontrib>Cellamaro, T</creatorcontrib><creatorcontrib>Soldati, E</creatorcontrib><creatorcontrib>Di Cori, A</creatorcontrib><creatorcontrib>Zucchelli, G</creatorcontrib><creatorcontrib>De Lucia, R</creatorcontrib><creatorcontrib>Viani, S</creatorcontrib><creatorcontrib>Paperini, L</creatorcontrib><creatorcontrib>Pedrinelli, R</creatorcontrib><creatorcontrib>Bongiorni, M G</creatorcontrib><title>P3139Transvenous lead extraction: lead age threshold to predict the success of the procedure</title><title>European heart journal</title><description>Abstract
Introduction
Transvenous lead extraction is a safe and effective procedure. The dwell time of the leads, with other factors, is associated with poor outcome of the procedure. However, a precise estimation of the success of the procedure is not available.
Purpose
The aim of this study is to identify a lead's age threshold able to predict the success of the transvenous lead extraction (TLE) procedure.
Methods
All patients who underwent TLE in our center from January 2009 to December 2017 were retrospectively analyzed. The primary endpoint was the clinical success of the procedure. The optimal cut-off threshold was determined by the analysis of Receiver-Operating Characteristics (ROC) curves, using the Youden index.
Results
We analyzed 1210 consecutive patients that required transvenous removal of 2343 leads (686 ICD leads, 1657 pacemaker leads, 322 coronary sinus leads). Clinical success was achieved in 1168 patients (96.5%). Dwelling time median of the oldest lead for a patient was 66 months (interquartile range 27.0–115.0). The oldest lead completely removed was 32 years old. ROC curve analysis showed a dwell time threshold of 107 months – 8,92 years - for clinical success (Positive Predictive Value: 99.5%; Negative Predictive Value: 7.8%) and the area under the curve (AUC) was 0.879. Comparison of ROC for dwelling time and the 0.5 curve was assessed as statistically significative (p<0.0001).
Conclusions
Transvenous lead extraction is an effective procedure. The best cut-off threshold to predict a very high clinical success is 107 months.</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkMtKw0AYhQdRsFYfQZgXSPvPNRN3UrxBQRdZuBDCzOSPSamdMJOI-vS2Rly7OpwD31l8hFwyWDAoxBLH2KKNw2aJ7Vcu1QI4k0dkxhTnWaGlOiYzYIXKtDbPp-QspQ0AGM30jLw8CSaKMtpdesddGBPdoq0pfgzR-qELu6tpsK9IhzZiasO2pkOgfcS688N-RJpG7zElGpqf2sfgsR4jnpOTxm4TXvzmnJS3N-XqPls_3j2srteZN7nMNJfGOS4UU9IwsMigcZDnTBUCOfeYe8dBYuMNdxJybWrrG5TghDNaWzEnarr1MaQUsan62L3Z-FkxqA6Gqj9D1WSoOhjaczBxYez_iXwDXHdu5Q</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Giannotti Santoro, M</creator><creator>Segreti, L</creator><creator>Fiorentini, F</creator><creator>Bernini, G</creator><creator>Barletta, V</creator><creator>Della Tommasina, V</creator><creator>Cellamaro, T</creator><creator>Soldati, E</creator><creator>Di Cori, A</creator><creator>Zucchelli, G</creator><creator>De Lucia, R</creator><creator>Viani, S</creator><creator>Paperini, L</creator><creator>Pedrinelli, R</creator><creator>Bongiorni, M G</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20191001</creationdate><title>P3139Transvenous lead extraction: lead age threshold to predict the success of the procedure</title><author>Giannotti Santoro, M ; Segreti, L ; Fiorentini, F ; Bernini, G ; Barletta, V ; Della Tommasina, V ; Cellamaro, T ; Soldati, E ; Di Cori, A ; Zucchelli, G ; De Lucia, R ; Viani, S ; Paperini, L ; Pedrinelli, R ; Bongiorni, M G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c874-6248bb235154810ae10fb0771593e22ce7cb204efc82b40768dacfe40b3b866a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giannotti Santoro, M</creatorcontrib><creatorcontrib>Segreti, L</creatorcontrib><creatorcontrib>Fiorentini, F</creatorcontrib><creatorcontrib>Bernini, G</creatorcontrib><creatorcontrib>Barletta, V</creatorcontrib><creatorcontrib>Della Tommasina, V</creatorcontrib><creatorcontrib>Cellamaro, T</creatorcontrib><creatorcontrib>Soldati, E</creatorcontrib><creatorcontrib>Di Cori, A</creatorcontrib><creatorcontrib>Zucchelli, G</creatorcontrib><creatorcontrib>De Lucia, R</creatorcontrib><creatorcontrib>Viani, S</creatorcontrib><creatorcontrib>Paperini, L</creatorcontrib><creatorcontrib>Pedrinelli, R</creatorcontrib><creatorcontrib>Bongiorni, M G</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giannotti Santoro, M</au><au>Segreti, L</au><au>Fiorentini, F</au><au>Bernini, G</au><au>Barletta, V</au><au>Della Tommasina, V</au><au>Cellamaro, T</au><au>Soldati, E</au><au>Di Cori, A</au><au>Zucchelli, G</au><au>De Lucia, R</au><au>Viani, S</au><au>Paperini, L</au><au>Pedrinelli, R</au><au>Bongiorni, M G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P3139Transvenous lead extraction: lead age threshold to predict the success of the procedure</atitle><jtitle>European heart journal</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>40</volume><issue>Supplement_1</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
Introduction
Transvenous lead extraction is a safe and effective procedure. The dwell time of the leads, with other factors, is associated with poor outcome of the procedure. However, a precise estimation of the success of the procedure is not available.
Purpose
The aim of this study is to identify a lead's age threshold able to predict the success of the transvenous lead extraction (TLE) procedure.
Methods
All patients who underwent TLE in our center from January 2009 to December 2017 were retrospectively analyzed. The primary endpoint was the clinical success of the procedure. The optimal cut-off threshold was determined by the analysis of Receiver-Operating Characteristics (ROC) curves, using the Youden index.
Results
We analyzed 1210 consecutive patients that required transvenous removal of 2343 leads (686 ICD leads, 1657 pacemaker leads, 322 coronary sinus leads). Clinical success was achieved in 1168 patients (96.5%). Dwelling time median of the oldest lead for a patient was 66 months (interquartile range 27.0–115.0). The oldest lead completely removed was 32 years old. ROC curve analysis showed a dwell time threshold of 107 months – 8,92 years - for clinical success (Positive Predictive Value: 99.5%; Negative Predictive Value: 7.8%) and the area under the curve (AUC) was 0.879. Comparison of ROC for dwelling time and the 0.5 curve was assessed as statistically significative (p<0.0001).
Conclusions
Transvenous lead extraction is an effective procedure. The best cut-off threshold to predict a very high clinical success is 107 months.</abstract><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehz745.0214</doi></addata></record> |
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| title | P3139Transvenous lead extraction: lead age threshold to predict the success of the procedure |
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