Prognostic value of cardiac magnetic resonance global circumferential strain assessed by feature tracking techniques in asymptomatic patients with significant aortic regurgitation
Abstract Introduction Cardiac magnetic resonance feature tracking (CMR-FT) deformation techniques have gained significant interest in recent years. They provide a comprehensive evaluation of myocardial function and improve the reproducibility of echocardiography strain techniques. Purpose The aim of...
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| creator | Carrion-Sanchez, I Ramos Cano, P Monteagudo Ruiz, J M Garcia Sebastian, C Hinojar Baydes, R Antonana Ugalde, S Garcia Martin, A Martinez-Vives, P Martin Pinacho, J Ayala Carbonero, A Gonzalez, A Zamorano, J L Fernandez-Golfin, C |
| description | Abstract
Introduction
Cardiac magnetic resonance feature tracking (CMR-FT) deformation techniques have gained significant interest in recent years. They provide a comprehensive evaluation of myocardial function and improve the reproducibility of echocardiography strain techniques.
Purpose
The aim of this study was to evaluate whether CMR-FT deformation parameters play a role predicting worse clinical evolution in patients with chronic significant aortic regurgitation (AR) not meeting guidelines intervention criteria.
Methods
We included 85 patients with significant AR (moderate, moderate/severe, and severe) referred for CMR. Only asymptomatic patients with preserved left ventricle ejection fraction (LVEF) were considered for inclusion. Other concomitant myocardiopathies were excluded. Conventional functional left chambers parameters as well as myocardial deformation were evaluated, including global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS). A composite clinical major outcome was assessed, including admission heart failure admission, need for aortic valvule replacement and all-cause mortality.
Results
The mean age of the sample was 62 years old. One third of the patients were females. Other clinical baseline characteristics were not significantly different between groups when compared with Chi-squared and T-test statistical analysis. Mean follow-up was 42 months (±31). 21 patients presented with the composited outcome previously described. End-diastolic and end-systolic volumes did not differ between groups. Mean end-diastolic volume (EDV) was 196 ± 6.1 mL and mean end-systolic volume (ESV) was 88 ± 3.4 mL. Mean values of CMR-FT GLS, GCS and GRS were -14.1%, 22.8% and -16.9% respectively. GCS was selected as the best predictor for the combined endpoint point, with and area under the ROC curve of 0.67. A GCS value |
| doi_str_mv | 10.1093/eurheartj/ehae666.258 |
| format | Article |
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Introduction
Cardiac magnetic resonance feature tracking (CMR-FT) deformation techniques have gained significant interest in recent years. They provide a comprehensive evaluation of myocardial function and improve the reproducibility of echocardiography strain techniques.
Purpose
The aim of this study was to evaluate whether CMR-FT deformation parameters play a role predicting worse clinical evolution in patients with chronic significant aortic regurgitation (AR) not meeting guidelines intervention criteria.
Methods
We included 85 patients with significant AR (moderate, moderate/severe, and severe) referred for CMR. Only asymptomatic patients with preserved left ventricle ejection fraction (LVEF) were considered for inclusion. Other concomitant myocardiopathies were excluded. Conventional functional left chambers parameters as well as myocardial deformation were evaluated, including global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS). A composite clinical major outcome was assessed, including admission heart failure admission, need for aortic valvule replacement and all-cause mortality.
Results
The mean age of the sample was 62 years old. One third of the patients were females. Other clinical baseline characteristics were not significantly different between groups when compared with Chi-squared and T-test statistical analysis. Mean follow-up was 42 months (±31). 21 patients presented with the composited outcome previously described. End-diastolic and end-systolic volumes did not differ between groups. Mean end-diastolic volume (EDV) was 196 ± 6.1 mL and mean end-systolic volume (ESV) was 88 ± 3.4 mL. Mean values of CMR-FT GLS, GCS and GRS were -14.1%, 22.8% and -16.9% respectively. GCS was selected as the best predictor for the combined endpoint point, with and area under the ROC curve of 0.67. A GCS value <-17% was selected as the optimal cut-off point. This value predicted events as is shown in Kaplan-Meier curves (HR 3.6, CI 95% 1.42 - 9.02, p = 0.007). A multivariate analysis showed that this association was independent of left ventricle (LV) ejection fraction, LV volumes and left atrial (LA) volume.
Conclusion
CMR-FT deformation parameters are impaired in significant AR patients even if intervention criteria are not met. A value of GCS < -17% in this population could predict a worse clinical evolution and emerges as a promising new tool helping clinical decision making in this challenging population.Kaplan-Meier curve free-event survival</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehae666.258</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>European heart journal, 2024-10, Vol.45 (Supplement_1)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids></links><search><creatorcontrib>Carrion-Sanchez, I</creatorcontrib><creatorcontrib>Ramos Cano, P</creatorcontrib><creatorcontrib>Monteagudo Ruiz, J M</creatorcontrib><creatorcontrib>Garcia Sebastian, C</creatorcontrib><creatorcontrib>Hinojar Baydes, R</creatorcontrib><creatorcontrib>Antonana Ugalde, S</creatorcontrib><creatorcontrib>Garcia Martin, A</creatorcontrib><creatorcontrib>Martinez-Vives, P</creatorcontrib><creatorcontrib>Martin Pinacho, J</creatorcontrib><creatorcontrib>Ayala Carbonero, A</creatorcontrib><creatorcontrib>Gonzalez, A</creatorcontrib><creatorcontrib>Zamorano, J L</creatorcontrib><creatorcontrib>Fernandez-Golfin, C</creatorcontrib><title>Prognostic value of cardiac magnetic resonance global circumferential strain assessed by feature tracking techniques in asymptomatic patients with significant aortic regurgitation</title><title>European heart journal</title><description>Abstract
Introduction
Cardiac magnetic resonance feature tracking (CMR-FT) deformation techniques have gained significant interest in recent years. They provide a comprehensive evaluation of myocardial function and improve the reproducibility of echocardiography strain techniques.
Purpose
The aim of this study was to evaluate whether CMR-FT deformation parameters play a role predicting worse clinical evolution in patients with chronic significant aortic regurgitation (AR) not meeting guidelines intervention criteria.
Methods
We included 85 patients with significant AR (moderate, moderate/severe, and severe) referred for CMR. Only asymptomatic patients with preserved left ventricle ejection fraction (LVEF) were considered for inclusion. Other concomitant myocardiopathies were excluded. Conventional functional left chambers parameters as well as myocardial deformation were evaluated, including global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS). A composite clinical major outcome was assessed, including admission heart failure admission, need for aortic valvule replacement and all-cause mortality.
Results
The mean age of the sample was 62 years old. One third of the patients were females. Other clinical baseline characteristics were not significantly different between groups when compared with Chi-squared and T-test statistical analysis. Mean follow-up was 42 months (±31). 21 patients presented with the composited outcome previously described. End-diastolic and end-systolic volumes did not differ between groups. Mean end-diastolic volume (EDV) was 196 ± 6.1 mL and mean end-systolic volume (ESV) was 88 ± 3.4 mL. Mean values of CMR-FT GLS, GCS and GRS were -14.1%, 22.8% and -16.9% respectively. GCS was selected as the best predictor for the combined endpoint point, with and area under the ROC curve of 0.67. A GCS value <-17% was selected as the optimal cut-off point. This value predicted events as is shown in Kaplan-Meier curves (HR 3.6, CI 95% 1.42 - 9.02, p = 0.007). A multivariate analysis showed that this association was independent of left ventricle (LV) ejection fraction, LV volumes and left atrial (LA) volume.
Conclusion
CMR-FT deformation parameters are impaired in significant AR patients even if intervention criteria are not met. A value of GCS < -17% in this population could predict a worse clinical evolution and emerges as a promising new tool helping clinical decision making in this challenging population.Kaplan-Meier curve free-event survival</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkE1qwzAQhUVpoenPEQq6gFPJthR5WUL_INAusujOjOWRozSWUkluybl6wTpN6LowzDC8eY_hI-SGsylnVXGLQ1ghhLS-xRWglHKaC3VCJlzkeVbJUpySCeOVyKRUb-fkIsY1Y0xJLifk-zX4zvmYrKafsBmQekM1hNaCpj10DvdKwOgdOI202_gGNlTboIfeYECX7LjHFMA6CjHiWC1tdtQgpCEgHRX9bl1HE-qVsx8DRvp7uuu3yfewz9-OfUyK9MumFY22c9ZYDS5R8OHwQDeEzqbxzrsrcmZgE_H6OC_J8uF-OX_KFi-Pz_O7RabVTGWqKITked5WujJaMMMbrngL2BSsUFKIsgEjFbQzI5nKdWlKXZWlqmRT5Eqw4pKIQ6wOPsaApt4G20PY1ZzVe_D1H_j6CL4ewY8-dvD5YftPyw8y_JJz</recordid><startdate>20241028</startdate><enddate>20241028</enddate><creator>Carrion-Sanchez, I</creator><creator>Ramos Cano, P</creator><creator>Monteagudo Ruiz, J M</creator><creator>Garcia Sebastian, C</creator><creator>Hinojar Baydes, R</creator><creator>Antonana Ugalde, S</creator><creator>Garcia Martin, A</creator><creator>Martinez-Vives, P</creator><creator>Martin Pinacho, J</creator><creator>Ayala Carbonero, A</creator><creator>Gonzalez, A</creator><creator>Zamorano, J L</creator><creator>Fernandez-Golfin, C</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20241028</creationdate><title>Prognostic value of cardiac magnetic resonance global circumferential strain assessed by feature tracking techniques in asymptomatic patients with significant aortic regurgitation</title><author>Carrion-Sanchez, I ; Ramos Cano, P ; Monteagudo Ruiz, J M ; Garcia Sebastian, C ; Hinojar Baydes, R ; Antonana Ugalde, S ; Garcia Martin, A ; Martinez-Vives, P ; Martin Pinacho, J ; Ayala Carbonero, A ; Gonzalez, A ; Zamorano, J L ; Fernandez-Golfin, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c878-83356122d9c9fc50f1b181daeb30386554baf68ad7f6082c4f4c944896b328503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrion-Sanchez, I</creatorcontrib><creatorcontrib>Ramos Cano, P</creatorcontrib><creatorcontrib>Monteagudo Ruiz, J M</creatorcontrib><creatorcontrib>Garcia Sebastian, C</creatorcontrib><creatorcontrib>Hinojar Baydes, R</creatorcontrib><creatorcontrib>Antonana Ugalde, S</creatorcontrib><creatorcontrib>Garcia Martin, A</creatorcontrib><creatorcontrib>Martinez-Vives, P</creatorcontrib><creatorcontrib>Martin Pinacho, J</creatorcontrib><creatorcontrib>Ayala Carbonero, A</creatorcontrib><creatorcontrib>Gonzalez, A</creatorcontrib><creatorcontrib>Zamorano, J L</creatorcontrib><creatorcontrib>Fernandez-Golfin, C</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrion-Sanchez, I</au><au>Ramos Cano, P</au><au>Monteagudo Ruiz, J M</au><au>Garcia Sebastian, C</au><au>Hinojar Baydes, R</au><au>Antonana Ugalde, S</au><au>Garcia Martin, A</au><au>Martinez-Vives, P</au><au>Martin Pinacho, J</au><au>Ayala Carbonero, A</au><au>Gonzalez, A</au><au>Zamorano, J L</au><au>Fernandez-Golfin, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of cardiac magnetic resonance global circumferential strain assessed by feature tracking techniques in asymptomatic patients with significant aortic regurgitation</atitle><jtitle>European heart journal</jtitle><date>2024-10-28</date><risdate>2024</risdate><volume>45</volume><issue>Supplement_1</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
Introduction
Cardiac magnetic resonance feature tracking (CMR-FT) deformation techniques have gained significant interest in recent years. They provide a comprehensive evaluation of myocardial function and improve the reproducibility of echocardiography strain techniques.
Purpose
The aim of this study was to evaluate whether CMR-FT deformation parameters play a role predicting worse clinical evolution in patients with chronic significant aortic regurgitation (AR) not meeting guidelines intervention criteria.
Methods
We included 85 patients with significant AR (moderate, moderate/severe, and severe) referred for CMR. Only asymptomatic patients with preserved left ventricle ejection fraction (LVEF) were considered for inclusion. Other concomitant myocardiopathies were excluded. Conventional functional left chambers parameters as well as myocardial deformation were evaluated, including global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS). A composite clinical major outcome was assessed, including admission heart failure admission, need for aortic valvule replacement and all-cause mortality.
Results
The mean age of the sample was 62 years old. One third of the patients were females. Other clinical baseline characteristics were not significantly different between groups when compared with Chi-squared and T-test statistical analysis. Mean follow-up was 42 months (±31). 21 patients presented with the composited outcome previously described. End-diastolic and end-systolic volumes did not differ between groups. Mean end-diastolic volume (EDV) was 196 ± 6.1 mL and mean end-systolic volume (ESV) was 88 ± 3.4 mL. Mean values of CMR-FT GLS, GCS and GRS were -14.1%, 22.8% and -16.9% respectively. GCS was selected as the best predictor for the combined endpoint point, with and area under the ROC curve of 0.67. A GCS value <-17% was selected as the optimal cut-off point. This value predicted events as is shown in Kaplan-Meier curves (HR 3.6, CI 95% 1.42 - 9.02, p = 0.007). A multivariate analysis showed that this association was independent of left ventricle (LV) ejection fraction, LV volumes and left atrial (LA) volume.
Conclusion
CMR-FT deformation parameters are impaired in significant AR patients even if intervention criteria are not met. A value of GCS < -17% in this population could predict a worse clinical evolution and emerges as a promising new tool helping clinical decision making in this challenging population.Kaplan-Meier curve free-event survival</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehae666.258</doi></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Prognostic value of cardiac magnetic resonance global circumferential strain assessed by feature tracking techniques in asymptomatic patients with significant aortic regurgitation |
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