Initial phase of anthracycline cardiotoxicity involves metabolic switch and activation of cardiac fibroblasts

Abstract Background Doxorubicin (DOX) is an effective anticancer drug, but its application is hampered by cardiotoxicity with asymptomatic diastolic dysfunction as the earliest manifestation. Interstitial fibrosis leads to impaired relaxation, but the timing of fibrotic process and the mechanisms th...

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Veröffentlicht in:	European heart journal 2023-11, Vol.44 (Supplement_2)
Hauptverfasser:	Urbanek, K, Donniacuo, M, Cappetta, D, Telesca, M, Riemma, M, Bellocchio, G, Berrino, L, Rossi, F, Castaldo, G, De Angelis, A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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