Evaluation of risk factors for long-term atrial fibrillation development in patients undergoing typical atrial flutter ablation: a multi-center pilot study
Abstract Background/Introduction Atrial flutter (AFL) and atrial fibrillation (AF) are the most commonly detected supraventricular arrhythmia and share similar pathophysiological mechanisms (1). After the successful ablation of AFL, AF frequently occurs in such patients in the long-term follow up (2...
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| Veröffentlicht in: | European heart journal 2023-11, Vol.44 (Supplement_2) |
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| creator | Yumurtas, A C Pay, L Tezen, O Cetin, T Yucedag, F F Arter, E Kadioglu, H Akgun, H Ozkan, E Uslu, A Kup, A Saylik, F Cinar, T Hayiroglu, M I |
| description | Abstract
Background/Introduction
Atrial flutter (AFL) and atrial fibrillation (AF) are the most commonly detected supraventricular arrhythmia and share similar pathophysiological mechanisms (1). After the successful ablation of AFL, AF frequently occurs in such patients in the long-term follow up (2). As emphasized in some studies, some mechanisms seem to predispose to the development of AF in AFL patients and approximately 20% of such kind of patients have accompanying AFL (3).
Purpose
We aim to analyze independent risk factors that predict the development of AF in patients who underwent typical AFL ablation.
Methods
Our study was designed as multi-center, cross-sectional and retrospective. A total of 442 patients who underwent typical AFL ablation at 3 different centers between January 1, 2018 and January 1, 2022 were included retrospectively. The patients after the ablation procedure were divided into those who developed AF and those who did not. The patients were followed up for an average of 12 (4-20) months. In the post-procedure period, atrial arrhythmias were investigated with 24-hour Holter and ECG at 1st month, 6th month, 12th month and at 6-month intervals thereafter.
Results
AF developed in 206 (46.6%) patients in the long-term follow-up. Age, hypertension (HT), obstructive sleep apnea syndrome (OSAS), previous cerebrovascular accident (CVA), left atrium antero-posterior diameter, severe mitral regurgitation, hemoglobin, blood glucose and HbA1c values were found to be significant in univariable analysis. According to multivariable analysis, HT (p=0.014; HR: 1.483 (1.084 – 2.030)), OSAS (p=0.008; HR: 1.520 (1.117 – 2.068)) and previous CVA (p=0.038; HR: 1.749) (1,031 – 2,968)) were independently associated with the development of AF in AFL patients who underwent ablation procedure.
Conclusion
In the present study, we found that HT, OSAS and previous CVA were independently correlated with the development of AF in the long-term follow-up of patients who underwent typical AFL ablation. We consider that AFL patients with such risk factors should be followed-up closely following cavo-tricuspid isthmus ablation for the development of AF.
Univariable and Multivariable Analyzes
Kaplan - Meier Curves |
| doi_str_mv | 10.1093/eurheartj/ehad655.408 |
| format | Article |
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Background/Introduction
Atrial flutter (AFL) and atrial fibrillation (AF) are the most commonly detected supraventricular arrhythmia and share similar pathophysiological mechanisms (1). After the successful ablation of AFL, AF frequently occurs in such patients in the long-term follow up (2). As emphasized in some studies, some mechanisms seem to predispose to the development of AF in AFL patients and approximately 20% of such kind of patients have accompanying AFL (3).
Purpose
We aim to analyze independent risk factors that predict the development of AF in patients who underwent typical AFL ablation.
Methods
Our study was designed as multi-center, cross-sectional and retrospective. A total of 442 patients who underwent typical AFL ablation at 3 different centers between January 1, 2018 and January 1, 2022 were included retrospectively. The patients after the ablation procedure were divided into those who developed AF and those who did not. The patients were followed up for an average of 12 (4-20) months. In the post-procedure period, atrial arrhythmias were investigated with 24-hour Holter and ECG at 1st month, 6th month, 12th month and at 6-month intervals thereafter.
Results
AF developed in 206 (46.6%) patients in the long-term follow-up. Age, hypertension (HT), obstructive sleep apnea syndrome (OSAS), previous cerebrovascular accident (CVA), left atrium antero-posterior diameter, severe mitral regurgitation, hemoglobin, blood glucose and HbA1c values were found to be significant in univariable analysis. According to multivariable analysis, HT (p=0.014; HR: 1.483 (1.084 – 2.030)), OSAS (p=0.008; HR: 1.520 (1.117 – 2.068)) and previous CVA (p=0.038; HR: 1.749) (1,031 – 2,968)) were independently associated with the development of AF in AFL patients who underwent ablation procedure.
Conclusion
In the present study, we found that HT, OSAS and previous CVA were independently correlated with the development of AF in the long-term follow-up of patients who underwent typical AFL ablation. We consider that AFL patients with such risk factors should be followed-up closely following cavo-tricuspid isthmus ablation for the development of AF.
Univariable and Multivariable Analyzes
Kaplan - Meier Curves</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehad655.408</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>European heart journal, 2023-11, Vol.44 (Supplement_2)</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Yumurtas, A C</creatorcontrib><creatorcontrib>Pay, L</creatorcontrib><creatorcontrib>Tezen, O</creatorcontrib><creatorcontrib>Cetin, T</creatorcontrib><creatorcontrib>Yucedag, F F</creatorcontrib><creatorcontrib>Arter, E</creatorcontrib><creatorcontrib>Kadioglu, H</creatorcontrib><creatorcontrib>Akgun, H</creatorcontrib><creatorcontrib>Ozkan, E</creatorcontrib><creatorcontrib>Uslu, A</creatorcontrib><creatorcontrib>Kup, A</creatorcontrib><creatorcontrib>Saylik, F</creatorcontrib><creatorcontrib>Cinar, T</creatorcontrib><creatorcontrib>Hayiroglu, M I</creatorcontrib><title>Evaluation of risk factors for long-term atrial fibrillation development in patients undergoing typical atrial flutter ablation: a multi-center pilot study</title><title>European heart journal</title><description>Abstract
Background/Introduction
Atrial flutter (AFL) and atrial fibrillation (AF) are the most commonly detected supraventricular arrhythmia and share similar pathophysiological mechanisms (1). After the successful ablation of AFL, AF frequently occurs in such patients in the long-term follow up (2). As emphasized in some studies, some mechanisms seem to predispose to the development of AF in AFL patients and approximately 20% of such kind of patients have accompanying AFL (3).
Purpose
We aim to analyze independent risk factors that predict the development of AF in patients who underwent typical AFL ablation.
Methods
Our study was designed as multi-center, cross-sectional and retrospective. A total of 442 patients who underwent typical AFL ablation at 3 different centers between January 1, 2018 and January 1, 2022 were included retrospectively. The patients after the ablation procedure were divided into those who developed AF and those who did not. The patients were followed up for an average of 12 (4-20) months. In the post-procedure period, atrial arrhythmias were investigated with 24-hour Holter and ECG at 1st month, 6th month, 12th month and at 6-month intervals thereafter.
Results
AF developed in 206 (46.6%) patients in the long-term follow-up. Age, hypertension (HT), obstructive sleep apnea syndrome (OSAS), previous cerebrovascular accident (CVA), left atrium antero-posterior diameter, severe mitral regurgitation, hemoglobin, blood glucose and HbA1c values were found to be significant in univariable analysis. According to multivariable analysis, HT (p=0.014; HR: 1.483 (1.084 – 2.030)), OSAS (p=0.008; HR: 1.520 (1.117 – 2.068)) and previous CVA (p=0.038; HR: 1.749) (1,031 – 2,968)) were independently associated with the development of AF in AFL patients who underwent ablation procedure.
Conclusion
In the present study, we found that HT, OSAS and previous CVA were independently correlated with the development of AF in the long-term follow-up of patients who underwent typical AFL ablation. We consider that AFL patients with such risk factors should be followed-up closely following cavo-tricuspid isthmus ablation for the development of AF.
Univariable and Multivariable Analyzes
Kaplan - Meier Curves</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkN1KwzAUgIMoOKePIOQFup22aZZ4J2P-gOCNgnclzc-WmTYlSQd7Fl_WSqfXXp3DOXzfxYfQbQ6LHHi51EPYaRHSfql3QtGqWhBgZ2iWV0WRcUqqczSDnFcZpezjEl3FuAcARnM6Q1-bg3CDSNZ32BscbPzERsjkQ8TGB-x8t82SDi0WKVjhsLFNsM5NhNIH7Xzf6i5h2-F-vI5rxEOndNh6221xOvZWjtwv7oY06rBoJsUdFrgdXLKZHMnx0VvnE45pUMdrdGGEi_rmNOfo_WHztn7KXl4fn9f3L5nMS8IyAZQUijBiCBNKATdUcyW5ySkDTYA3QhGyEiWhBCQ0TMOKEsKJkYIVAOUcVZNXBh9j0Kbug21FONY51D-F67_C9alwPRYeOZg4P_T_RL4B2RyIxw</recordid><startdate>20231109</startdate><enddate>20231109</enddate><creator>Yumurtas, A C</creator><creator>Pay, L</creator><creator>Tezen, O</creator><creator>Cetin, T</creator><creator>Yucedag, F F</creator><creator>Arter, E</creator><creator>Kadioglu, H</creator><creator>Akgun, H</creator><creator>Ozkan, E</creator><creator>Uslu, A</creator><creator>Kup, A</creator><creator>Saylik, F</creator><creator>Cinar, T</creator><creator>Hayiroglu, M I</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231109</creationdate><title>Evaluation of risk factors for long-term atrial fibrillation development in patients undergoing typical atrial flutter ablation: a multi-center pilot study</title><author>Yumurtas, A C ; Pay, L ; Tezen, O ; Cetin, T ; Yucedag, F F ; Arter, E ; Kadioglu, H ; Akgun, H ; Ozkan, E ; Uslu, A ; Kup, A ; Saylik, F ; Cinar, T ; Hayiroglu, M I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1348-a0642d484f48add09f6e9dc9f1680e409bad447a34640c0b8e0764494fca82003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yumurtas, A C</creatorcontrib><creatorcontrib>Pay, L</creatorcontrib><creatorcontrib>Tezen, O</creatorcontrib><creatorcontrib>Cetin, T</creatorcontrib><creatorcontrib>Yucedag, F F</creatorcontrib><creatorcontrib>Arter, E</creatorcontrib><creatorcontrib>Kadioglu, H</creatorcontrib><creatorcontrib>Akgun, H</creatorcontrib><creatorcontrib>Ozkan, E</creatorcontrib><creatorcontrib>Uslu, A</creatorcontrib><creatorcontrib>Kup, A</creatorcontrib><creatorcontrib>Saylik, F</creatorcontrib><creatorcontrib>Cinar, T</creatorcontrib><creatorcontrib>Hayiroglu, M I</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yumurtas, A C</au><au>Pay, L</au><au>Tezen, O</au><au>Cetin, T</au><au>Yucedag, F F</au><au>Arter, E</au><au>Kadioglu, H</au><au>Akgun, H</au><au>Ozkan, E</au><au>Uslu, A</au><au>Kup, A</au><au>Saylik, F</au><au>Cinar, T</au><au>Hayiroglu, M I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of risk factors for long-term atrial fibrillation development in patients undergoing typical atrial flutter ablation: a multi-center pilot study</atitle><jtitle>European heart journal</jtitle><date>2023-11-09</date><risdate>2023</risdate><volume>44</volume><issue>Supplement_2</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
Background/Introduction
Atrial flutter (AFL) and atrial fibrillation (AF) are the most commonly detected supraventricular arrhythmia and share similar pathophysiological mechanisms (1). After the successful ablation of AFL, AF frequently occurs in such patients in the long-term follow up (2). As emphasized in some studies, some mechanisms seem to predispose to the development of AF in AFL patients and approximately 20% of such kind of patients have accompanying AFL (3).
Purpose
We aim to analyze independent risk factors that predict the development of AF in patients who underwent typical AFL ablation.
Methods
Our study was designed as multi-center, cross-sectional and retrospective. A total of 442 patients who underwent typical AFL ablation at 3 different centers between January 1, 2018 and January 1, 2022 were included retrospectively. The patients after the ablation procedure were divided into those who developed AF and those who did not. The patients were followed up for an average of 12 (4-20) months. In the post-procedure period, atrial arrhythmias were investigated with 24-hour Holter and ECG at 1st month, 6th month, 12th month and at 6-month intervals thereafter.
Results
AF developed in 206 (46.6%) patients in the long-term follow-up. Age, hypertension (HT), obstructive sleep apnea syndrome (OSAS), previous cerebrovascular accident (CVA), left atrium antero-posterior diameter, severe mitral regurgitation, hemoglobin, blood glucose and HbA1c values were found to be significant in univariable analysis. According to multivariable analysis, HT (p=0.014; HR: 1.483 (1.084 – 2.030)), OSAS (p=0.008; HR: 1.520 (1.117 – 2.068)) and previous CVA (p=0.038; HR: 1.749) (1,031 – 2,968)) were independently associated with the development of AF in AFL patients who underwent ablation procedure.
Conclusion
In the present study, we found that HT, OSAS and previous CVA were independently correlated with the development of AF in the long-term follow-up of patients who underwent typical AFL ablation. We consider that AFL patients with such risk factors should be followed-up closely following cavo-tricuspid isthmus ablation for the development of AF.
Univariable and Multivariable Analyzes
Kaplan - Meier Curves</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehad655.408</doi><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Evaluation of risk factors for long-term atrial fibrillation development in patients undergoing typical atrial flutter ablation: a multi-center pilot study |
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