Blood and imaging biomarkers in the long-term follow-up of bicuspid aortic valve patients
Abstract Background Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as arrhythmias and reinterventions. Purpose This study aimed to investigate (1) sex differences in blood and imaging biomarkers and (2) the role of bloo...
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| Veröffentlicht in: | European heart journal 2023-11, Vol.44 (Supplement_2) |
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| creator | Hendriks, P Keuning, Z A Duijnhouwer, A L Meccanici, F Siebelink, H J Van Den Hoven, A T Geenen, L W Eindhoven, J A Baggen, V J M Cuypers, J E A A Kauling, R M Roos-Hesselink, J W Van Den Bosch, A E |
| description | Abstract
Background
Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as arrhythmias and reinterventions.
Purpose
This study aimed to investigate (1) sex differences in blood and imaging biomarkers and (2) the role of blood and echocardiographic biomarkers in the long-term risk prediction of patients with BAV.
Methods
In this multicenter prospective observational study, all included adult BAV patients underwent venous blood sampling and transthoracic echocardiography including speckle tracking at the time of inclusion. Analyzed blood biomarkers were: RDW, creatinine, CRP, TroponinT, NT-proBNP and TGF-beta. Sex differences were analyzed at baseline. Associations between blood & echocardiographic biomarkers and arrhythmia-free & intervention-free survival were determined by Cox proportional hazards models.
Results
A total of 182 patients were included (median age 34 (Interquartile range: 23-46) years, 55.5% male). Significant differences were found in blood biomarkers at baseline between men and women. CRP, NT-proBNP and RDW were higher in women while creatinine, TroponinT and TGF-beta were higher among men (figure 1). After a median follow-up time up of 6.9 (IQR: 6.5- 9.9) years, arrhythmia-free and event-free survival rates were respectively 81.0% and 73.1%. NT-proBNP was the only blood biomarker independently associated with both arrhythmia free and intervention free survival. On echocardiography an increase in LA size, LVEDD, LV mass index and E/E’ratio were associated with arrhythmia free survival. Intervention free survival was associated with increased LA size, LV mass index, aortic valve peak velocity and the presence of moderate or severe aortic regurgitation. No associations were found with ejection fraction and global longitudinal strain (figure 2).
Conclusion
Significant sex-related differences were observed in blood biomarkers between men and women with BAV at baseline. NT-proBNP was the only blood biomarker associated with arrhythmia-and intervention-free survival. The strongest associations of echocardiographic markers were those indicating diastolic function and LV mass index.Sex differences in blood biomarkersForest plot |
| doi_str_mv | 10.1093/eurheartj/ehad655.1934 |
| format | Article |
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Background
Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as arrhythmias and reinterventions.
Purpose
This study aimed to investigate (1) sex differences in blood and imaging biomarkers and (2) the role of blood and echocardiographic biomarkers in the long-term risk prediction of patients with BAV.
Methods
In this multicenter prospective observational study, all included adult BAV patients underwent venous blood sampling and transthoracic echocardiography including speckle tracking at the time of inclusion. Analyzed blood biomarkers were: RDW, creatinine, CRP, TroponinT, NT-proBNP and TGF-beta. Sex differences were analyzed at baseline. Associations between blood & echocardiographic biomarkers and arrhythmia-free & intervention-free survival were determined by Cox proportional hazards models.
Results
A total of 182 patients were included (median age 34 (Interquartile range: 23-46) years, 55.5% male). Significant differences were found in blood biomarkers at baseline between men and women. CRP, NT-proBNP and RDW were higher in women while creatinine, TroponinT and TGF-beta were higher among men (figure 1). After a median follow-up time up of 6.9 (IQR: 6.5- 9.9) years, arrhythmia-free and event-free survival rates were respectively 81.0% and 73.1%. NT-proBNP was the only blood biomarker independently associated with both arrhythmia free and intervention free survival. On echocardiography an increase in LA size, LVEDD, LV mass index and E/E’ratio were associated with arrhythmia free survival. Intervention free survival was associated with increased LA size, LV mass index, aortic valve peak velocity and the presence of moderate or severe aortic regurgitation. No associations were found with ejection fraction and global longitudinal strain (figure 2).
Conclusion
Significant sex-related differences were observed in blood biomarkers between men and women with BAV at baseline. NT-proBNP was the only blood biomarker associated with arrhythmia-and intervention-free survival. The strongest associations of echocardiographic markers were those indicating diastolic function and LV mass index.Sex differences in blood biomarkersForest plot</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehad655.1934</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>European heart journal, 2023-11, Vol.44 (Supplement_2)</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hendriks, P</creatorcontrib><creatorcontrib>Keuning, Z A</creatorcontrib><creatorcontrib>Duijnhouwer, A L</creatorcontrib><creatorcontrib>Meccanici, F</creatorcontrib><creatorcontrib>Siebelink, H J</creatorcontrib><creatorcontrib>Van Den Hoven, A T</creatorcontrib><creatorcontrib>Geenen, L W</creatorcontrib><creatorcontrib>Eindhoven, J A</creatorcontrib><creatorcontrib>Baggen, V J M</creatorcontrib><creatorcontrib>Cuypers, J E A A</creatorcontrib><creatorcontrib>Kauling, R M</creatorcontrib><creatorcontrib>Roos-Hesselink, J W</creatorcontrib><creatorcontrib>Van Den Bosch, A E</creatorcontrib><title>Blood and imaging biomarkers in the long-term follow-up of bicuspid aortic valve patients</title><title>European heart journal</title><description>Abstract
Background
Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as arrhythmias and reinterventions.
Purpose
This study aimed to investigate (1) sex differences in blood and imaging biomarkers and (2) the role of blood and echocardiographic biomarkers in the long-term risk prediction of patients with BAV.
Methods
In this multicenter prospective observational study, all included adult BAV patients underwent venous blood sampling and transthoracic echocardiography including speckle tracking at the time of inclusion. Analyzed blood biomarkers were: RDW, creatinine, CRP, TroponinT, NT-proBNP and TGF-beta. Sex differences were analyzed at baseline. Associations between blood & echocardiographic biomarkers and arrhythmia-free & intervention-free survival were determined by Cox proportional hazards models.
Results
A total of 182 patients were included (median age 34 (Interquartile range: 23-46) years, 55.5% male). Significant differences were found in blood biomarkers at baseline between men and women. CRP, NT-proBNP and RDW were higher in women while creatinine, TroponinT and TGF-beta were higher among men (figure 1). After a median follow-up time up of 6.9 (IQR: 6.5- 9.9) years, arrhythmia-free and event-free survival rates were respectively 81.0% and 73.1%. NT-proBNP was the only blood biomarker independently associated with both arrhythmia free and intervention free survival. On echocardiography an increase in LA size, LVEDD, LV mass index and E/E’ratio were associated with arrhythmia free survival. Intervention free survival was associated with increased LA size, LV mass index, aortic valve peak velocity and the presence of moderate or severe aortic regurgitation. No associations were found with ejection fraction and global longitudinal strain (figure 2).
Conclusion
Significant sex-related differences were observed in blood biomarkers between men and women with BAV at baseline. NT-proBNP was the only blood biomarker associated with arrhythmia-and intervention-free survival. The strongest associations of echocardiographic markers were those indicating diastolic function and LV mass index.Sex differences in blood biomarkersForest plot</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0EEqXwC8g_kHYcx669hIqXVIkNSLCKnHjSuqRxZCdF_D2uWrFmdTf3jOYeQm4ZzBhoPscxbNCEYTvHjbFSiBnTvDgjEybyPNOyEOdkAkyLTEr1cUmuYtwCgJJMTsjnfeu9paaz1O3M2nVrWjm_M-ELQ6Suo8MGaeu7dTZg2NHGt63_zsae-iYV6zH2LtE-DK6me9PukfZmcNgN8ZpcNKaNeHPKKXl_fHhbPmer16eX5d0qqxlfFJlGxQrLCw5VelcaBdLU0kBuOTBZcV2jXSgBaYYSaGEhBVdaWch1YtDwKZHHu3XwMQZsyj6kKeGnZFAeBJV_gsqToPIgKIHsCPqx_y_zC5T4bmU</recordid><startdate>20231109</startdate><enddate>20231109</enddate><creator>Hendriks, P</creator><creator>Keuning, Z A</creator><creator>Duijnhouwer, A L</creator><creator>Meccanici, F</creator><creator>Siebelink, H J</creator><creator>Van Den Hoven, A T</creator><creator>Geenen, L W</creator><creator>Eindhoven, J A</creator><creator>Baggen, V J M</creator><creator>Cuypers, J E A A</creator><creator>Kauling, R M</creator><creator>Roos-Hesselink, J W</creator><creator>Van Den Bosch, A E</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231109</creationdate><title>Blood and imaging biomarkers in the long-term follow-up of bicuspid aortic valve patients</title><author>Hendriks, P ; Keuning, Z A ; Duijnhouwer, A L ; Meccanici, F ; Siebelink, H J ; Van Den Hoven, A T ; Geenen, L W ; Eindhoven, J A ; Baggen, V J M ; Cuypers, J E A A ; Kauling, R M ; Roos-Hesselink, J W ; Van Den Bosch, A E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1374-9e814d3430b5226a806ac6a02d3016b39ced785064585ed07653898d029430ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hendriks, P</creatorcontrib><creatorcontrib>Keuning, Z A</creatorcontrib><creatorcontrib>Duijnhouwer, A L</creatorcontrib><creatorcontrib>Meccanici, F</creatorcontrib><creatorcontrib>Siebelink, H J</creatorcontrib><creatorcontrib>Van Den Hoven, A T</creatorcontrib><creatorcontrib>Geenen, L W</creatorcontrib><creatorcontrib>Eindhoven, J A</creatorcontrib><creatorcontrib>Baggen, V J M</creatorcontrib><creatorcontrib>Cuypers, J E A A</creatorcontrib><creatorcontrib>Kauling, R M</creatorcontrib><creatorcontrib>Roos-Hesselink, J W</creatorcontrib><creatorcontrib>Van Den Bosch, A E</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hendriks, P</au><au>Keuning, Z A</au><au>Duijnhouwer, A L</au><au>Meccanici, F</au><au>Siebelink, H J</au><au>Van Den Hoven, A T</au><au>Geenen, L W</au><au>Eindhoven, J A</au><au>Baggen, V J M</au><au>Cuypers, J E A A</au><au>Kauling, R M</au><au>Roos-Hesselink, J W</au><au>Van Den Bosch, A E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood and imaging biomarkers in the long-term follow-up of bicuspid aortic valve patients</atitle><jtitle>European heart journal</jtitle><date>2023-11-09</date><risdate>2023</risdate><volume>44</volume><issue>Supplement_2</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
Background
Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as arrhythmias and reinterventions.
Purpose
This study aimed to investigate (1) sex differences in blood and imaging biomarkers and (2) the role of blood and echocardiographic biomarkers in the long-term risk prediction of patients with BAV.
Methods
In this multicenter prospective observational study, all included adult BAV patients underwent venous blood sampling and transthoracic echocardiography including speckle tracking at the time of inclusion. Analyzed blood biomarkers were: RDW, creatinine, CRP, TroponinT, NT-proBNP and TGF-beta. Sex differences were analyzed at baseline. Associations between blood & echocardiographic biomarkers and arrhythmia-free & intervention-free survival were determined by Cox proportional hazards models.
Results
A total of 182 patients were included (median age 34 (Interquartile range: 23-46) years, 55.5% male). Significant differences were found in blood biomarkers at baseline between men and women. CRP, NT-proBNP and RDW were higher in women while creatinine, TroponinT and TGF-beta were higher among men (figure 1). After a median follow-up time up of 6.9 (IQR: 6.5- 9.9) years, arrhythmia-free and event-free survival rates were respectively 81.0% and 73.1%. NT-proBNP was the only blood biomarker independently associated with both arrhythmia free and intervention free survival. On echocardiography an increase in LA size, LVEDD, LV mass index and E/E’ratio were associated with arrhythmia free survival. Intervention free survival was associated with increased LA size, LV mass index, aortic valve peak velocity and the presence of moderate or severe aortic regurgitation. No associations were found with ejection fraction and global longitudinal strain (figure 2).
Conclusion
Significant sex-related differences were observed in blood biomarkers between men and women with BAV at baseline. NT-proBNP was the only blood biomarker associated with arrhythmia-and intervention-free survival. The strongest associations of echocardiographic markers were those indicating diastolic function and LV mass index.Sex differences in blood biomarkersForest plot</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehad655.1934</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Blood and imaging biomarkers in the long-term follow-up of bicuspid aortic valve patients |
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