Acute modification of hemodynamic forces in patients with severe aortic stenosis after transcatheter aortic valve replacement

Abstract Funding Acknowledgements Type of funding sources: None. Background Transcatheter-Aortic-Valve-Implantation (TAVI) is the established first-line treatment for patient with severe aortic stenosis not suitable for surgery. Echocardiographic evaluation of hemodynamic forces (HDFs) is a growing field, holding the potential to early predict improvement in LV function. Methods A prospective observational study was conducted. Transthoracic echocardiography was performed before and after TAVI. HDFs were analyzed along with traditional left ventricular (LV) function parameters. Results 25 consecutive patients undergoing TAVI were enrolled: mean age 83±5 years, 74.5% male, mean LV Ejection Fraction (LVEF) at baseline 57±8%. Post-TAVI echocardiographic evaluation was performed 2.4±1.06 days after the procedure. HDFs amplitude parameters improved significantly after the procedure: LV Longitudinal Forces (LF) apex-base [mean difference (MD) 1.79%; 95%CI 1.07–2.5; P-value