Left atrial strain determinants across heart failure stages; insight from MASCOT registry
Abstract Funding Acknowledgements Type of funding sources: None. OnBehalf MASCOT investigators Background Few studies analyzed left atrial (LA) peak atrial longitudinal strain (PALS) determinants, particularly across heart failure (HF) stages. We aimed to analyze the pathophysiological and clinical...
Gespeichert in:
| Veröffentlicht in: | European heart journal cardiovascular imaging 2022-02, Vol.23 (Supplement_1) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | Supplement_1 |
| container_start_page | |
| container_title | European heart journal cardiovascular imaging |
| container_volume | 23 |
| creator | Benfari, G Mandoli, GE Magne, J Miglioranza, M Ancona, R Reskovic Luksic, V Pastore, MC Santoro, C Michalski, B Muraru, D Donal, E Cosyns, B Edvardsen, T Popescu, B Cameli, M |
| description | Abstract
Funding Acknowledgements
Type of funding sources: None.
OnBehalf
MASCOT investigators
Background
Few studies analyzed left atrial (LA) peak atrial longitudinal strain (PALS) determinants, particularly across heart failure (HF) stages. We aimed to analyze the pathophysiological and clinical PALS correlates in a large international prospective registry.
Methods
This is a multicenter prospective observational study enrolling 745 patients with HF stages 0-C from July to October 2018. Data included PALS and left ventricular global longitudinal strain (LV-GLS). Exclusion criteria were: valvular prosthesis; atrial fibrillation; cardiac transplantation; poor acoustic window.
Results
Median global PALS was 17% [24-32]. 29% of patients were in HF-stage 0/A, 35% in stage-B, and 36% in stage-C. Together with age, the echocardiographic determinants of PALS were LA volume and LV-GLS (overall model R²=0.50, p |
| doi_str_mv | 10.1093/ehjci/jeab289.078 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ehjci_jeab289_078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ehjci/jeab289.078</oup_id><sourcerecordid>10.1093/ehjci/jeab289.078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1278-f6b0005a0c5f75ea38e70683c4bb3521b72bafbca96b11f5998fe89be66ad8393</originalsourceid><addsrcrecordid>eNqNkMtqwzAQRUVpoSHNB3SnD6gTSX5JdBVMX-CSRdNFV2bkjGwZP4LkLPL3dR503dnMMNx7uRxCHjlbcqbCFdZNaVcNghZSLVkqb8hMsCgNRMTF7d_Nonuy8L5h08RREgk-Iz85mpHC6Cy01I8ObE93OKLrbA_96CmUbvCe1ghupAZse3A4CaFC_0xt721VT383dPRz_ZVtttRhZaeg4wO5M9B6XFz3nHy_vmyz9yDfvH1k6zwouUhlYBJ9qgOsjE0aI4QSU5bIsIy0DmPBdSo0GF2CSjTnJlZKGpRKY5LAToYqnBN-yT0XdWiKvbMduGPBWXHCU5zxFFc8xYRn8jxdPMNh_w_5L_vsapA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Left atrial strain determinants across heart failure stages; insight from MASCOT registry</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Benfari, G ; Mandoli, GE ; Magne, J ; Miglioranza, M ; Ancona, R ; Reskovic Luksic, V ; Pastore, MC ; Santoro, C ; Michalski, B ; Muraru, D ; Donal, E ; Cosyns, B ; Edvardsen, T ; Popescu, B ; Cameli, M</creator><creatorcontrib>Benfari, G ; Mandoli, GE ; Magne, J ; Miglioranza, M ; Ancona, R ; Reskovic Luksic, V ; Pastore, MC ; Santoro, C ; Michalski, B ; Muraru, D ; Donal, E ; Cosyns, B ; Edvardsen, T ; Popescu, B ; Cameli, M</creatorcontrib><description><![CDATA[Abstract
Funding Acknowledgements
Type of funding sources: None.
OnBehalf
MASCOT investigators
Background
Few studies analyzed left atrial (LA) peak atrial longitudinal strain (PALS) determinants, particularly across heart failure (HF) stages. We aimed to analyze the pathophysiological and clinical PALS correlates in a large international prospective registry.
Methods
This is a multicenter prospective observational study enrolling 745 patients with HF stages 0-C from July to October 2018. Data included PALS and left ventricular global longitudinal strain (LV-GLS). Exclusion criteria were: valvular prosthesis; atrial fibrillation; cardiac transplantation; poor acoustic window.
Results
Median global PALS was 17% [24-32]. 29% of patients were in HF-stage 0/A, 35% in stage-B, and 36% in stage-C. Together with age, the echocardiographic determinants of PALS were LA volume and LV-GLS (overall model R²=0.50, p < 0.0001). LV-GLS had the strongest association with PALS at multivariable analysis (beta:-3.60 ± 0.20, p < 0.0001). Among HF-stages (Figure 1), LV-GLS remained the most important PALS predictor (p < 0.0001) whereas age was only associated with PALS in lower HF-stage 0/A or B (R=-0.26 p < 0.0001, R=-0.23 p = 0.0001). LA volume increased its association to PALS moving from stage 0-A (R=-0.11; P = 0.1) to C (R=-0.42; P < 0.0001). PALS was the single most potent echocardiographic parameter in predicting HF stage (AUC for B vs. 0/A 0.81, and AUC vs. 0/A for C 0.76). PALS remained independently associated with HF stages after adjusting for ejection fraction, E/e’ ratio and mitral regurgitation grade (p < 0.0001).
Conclusion
Although influenced by LV-GLS and LA size across HF-stages, PALS is incrementally and independently associated with clinical status. LA function may reflect a substantial part of the hemodynamic consequences of ventricular dysfunction.
Abstract Figure 1]]></description><identifier>ISSN: 2047-2404</identifier><identifier>EISSN: 2047-2412</identifier><identifier>DOI: 10.1093/ehjci/jeab289.078</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal cardiovascular imaging, 2022-02, Vol.23 (Supplement_1)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2022. For permissions, please email: journals.permissions@oup.com. 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1278-f6b0005a0c5f75ea38e70683c4bb3521b72bafbca96b11f5998fe89be66ad8393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Benfari, G</creatorcontrib><creatorcontrib>Mandoli, GE</creatorcontrib><creatorcontrib>Magne, J</creatorcontrib><creatorcontrib>Miglioranza, M</creatorcontrib><creatorcontrib>Ancona, R</creatorcontrib><creatorcontrib>Reskovic Luksic, V</creatorcontrib><creatorcontrib>Pastore, MC</creatorcontrib><creatorcontrib>Santoro, C</creatorcontrib><creatorcontrib>Michalski, B</creatorcontrib><creatorcontrib>Muraru, D</creatorcontrib><creatorcontrib>Donal, E</creatorcontrib><creatorcontrib>Cosyns, B</creatorcontrib><creatorcontrib>Edvardsen, T</creatorcontrib><creatorcontrib>Popescu, B</creatorcontrib><creatorcontrib>Cameli, M</creatorcontrib><title>Left atrial strain determinants across heart failure stages; insight from MASCOT registry</title><title>European heart journal cardiovascular imaging</title><description><![CDATA[Abstract
Funding Acknowledgements
Type of funding sources: None.
OnBehalf
MASCOT investigators
Background
Few studies analyzed left atrial (LA) peak atrial longitudinal strain (PALS) determinants, particularly across heart failure (HF) stages. We aimed to analyze the pathophysiological and clinical PALS correlates in a large international prospective registry.
Methods
This is a multicenter prospective observational study enrolling 745 patients with HF stages 0-C from July to October 2018. Data included PALS and left ventricular global longitudinal strain (LV-GLS). Exclusion criteria were: valvular prosthesis; atrial fibrillation; cardiac transplantation; poor acoustic window.
Results
Median global PALS was 17% [24-32]. 29% of patients were in HF-stage 0/A, 35% in stage-B, and 36% in stage-C. Together with age, the echocardiographic determinants of PALS were LA volume and LV-GLS (overall model R²=0.50, p < 0.0001). LV-GLS had the strongest association with PALS at multivariable analysis (beta:-3.60 ± 0.20, p < 0.0001). Among HF-stages (Figure 1), LV-GLS remained the most important PALS predictor (p < 0.0001) whereas age was only associated with PALS in lower HF-stage 0/A or B (R=-0.26 p < 0.0001, R=-0.23 p = 0.0001). LA volume increased its association to PALS moving from stage 0-A (R=-0.11; P = 0.1) to C (R=-0.42; P < 0.0001). PALS was the single most potent echocardiographic parameter in predicting HF stage (AUC for B vs. 0/A 0.81, and AUC vs. 0/A for C 0.76). PALS remained independently associated with HF stages after adjusting for ejection fraction, E/e’ ratio and mitral regurgitation grade (p < 0.0001).
Conclusion
Although influenced by LV-GLS and LA size across HF-stages, PALS is incrementally and independently associated with clinical status. LA function may reflect a substantial part of the hemodynamic consequences of ventricular dysfunction.
Abstract Figure 1]]></description><issn>2047-2404</issn><issn>2047-2412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNkMtqwzAQRUVpoSHNB3SnD6gTSX5JdBVMX-CSRdNFV2bkjGwZP4LkLPL3dR503dnMMNx7uRxCHjlbcqbCFdZNaVcNghZSLVkqb8hMsCgNRMTF7d_Nonuy8L5h08RREgk-Iz85mpHC6Cy01I8ObE93OKLrbA_96CmUbvCe1ghupAZse3A4CaFC_0xt721VT383dPRz_ZVtttRhZaeg4wO5M9B6XFz3nHy_vmyz9yDfvH1k6zwouUhlYBJ9qgOsjE0aI4QSU5bIsIy0DmPBdSo0GF2CSjTnJlZKGpRKY5LAToYqnBN-yT0XdWiKvbMduGPBWXHCU5zxFFc8xYRn8jxdPMNh_w_5L_vsapA</recordid><startdate>20220204</startdate><enddate>20220204</enddate><creator>Benfari, G</creator><creator>Mandoli, GE</creator><creator>Magne, J</creator><creator>Miglioranza, M</creator><creator>Ancona, R</creator><creator>Reskovic Luksic, V</creator><creator>Pastore, MC</creator><creator>Santoro, C</creator><creator>Michalski, B</creator><creator>Muraru, D</creator><creator>Donal, E</creator><creator>Cosyns, B</creator><creator>Edvardsen, T</creator><creator>Popescu, B</creator><creator>Cameli, M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220204</creationdate><title>Left atrial strain determinants across heart failure stages; insight from MASCOT registry</title><author>Benfari, G ; Mandoli, GE ; Magne, J ; Miglioranza, M ; Ancona, R ; Reskovic Luksic, V ; Pastore, MC ; Santoro, C ; Michalski, B ; Muraru, D ; Donal, E ; Cosyns, B ; Edvardsen, T ; Popescu, B ; Cameli, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1278-f6b0005a0c5f75ea38e70683c4bb3521b72bafbca96b11f5998fe89be66ad8393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benfari, G</creatorcontrib><creatorcontrib>Mandoli, GE</creatorcontrib><creatorcontrib>Magne, J</creatorcontrib><creatorcontrib>Miglioranza, M</creatorcontrib><creatorcontrib>Ancona, R</creatorcontrib><creatorcontrib>Reskovic Luksic, V</creatorcontrib><creatorcontrib>Pastore, MC</creatorcontrib><creatorcontrib>Santoro, C</creatorcontrib><creatorcontrib>Michalski, B</creatorcontrib><creatorcontrib>Muraru, D</creatorcontrib><creatorcontrib>Donal, E</creatorcontrib><creatorcontrib>Cosyns, B</creatorcontrib><creatorcontrib>Edvardsen, T</creatorcontrib><creatorcontrib>Popescu, B</creatorcontrib><creatorcontrib>Cameli, M</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benfari, G</au><au>Mandoli, GE</au><au>Magne, J</au><au>Miglioranza, M</au><au>Ancona, R</au><au>Reskovic Luksic, V</au><au>Pastore, MC</au><au>Santoro, C</au><au>Michalski, B</au><au>Muraru, D</au><au>Donal, E</au><au>Cosyns, B</au><au>Edvardsen, T</au><au>Popescu, B</au><au>Cameli, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left atrial strain determinants across heart failure stages; insight from MASCOT registry</atitle><jtitle>European heart journal cardiovascular imaging</jtitle><date>2022-02-04</date><risdate>2022</risdate><volume>23</volume><issue>Supplement_1</issue><issn>2047-2404</issn><eissn>2047-2412</eissn><abstract><![CDATA[Abstract
Funding Acknowledgements
Type of funding sources: None.
OnBehalf
MASCOT investigators
Background
Few studies analyzed left atrial (LA) peak atrial longitudinal strain (PALS) determinants, particularly across heart failure (HF) stages. We aimed to analyze the pathophysiological and clinical PALS correlates in a large international prospective registry.
Methods
This is a multicenter prospective observational study enrolling 745 patients with HF stages 0-C from July to October 2018. Data included PALS and left ventricular global longitudinal strain (LV-GLS). Exclusion criteria were: valvular prosthesis; atrial fibrillation; cardiac transplantation; poor acoustic window.
Results
Median global PALS was 17% [24-32]. 29% of patients were in HF-stage 0/A, 35% in stage-B, and 36% in stage-C. Together with age, the echocardiographic determinants of PALS were LA volume and LV-GLS (overall model R²=0.50, p < 0.0001). LV-GLS had the strongest association with PALS at multivariable analysis (beta:-3.60 ± 0.20, p < 0.0001). Among HF-stages (Figure 1), LV-GLS remained the most important PALS predictor (p < 0.0001) whereas age was only associated with PALS in lower HF-stage 0/A or B (R=-0.26 p < 0.0001, R=-0.23 p = 0.0001). LA volume increased its association to PALS moving from stage 0-A (R=-0.11; P = 0.1) to C (R=-0.42; P < 0.0001). PALS was the single most potent echocardiographic parameter in predicting HF stage (AUC for B vs. 0/A 0.81, and AUC vs. 0/A for C 0.76). PALS remained independently associated with HF stages after adjusting for ejection fraction, E/e’ ratio and mitral regurgitation grade (p < 0.0001).
Conclusion
Although influenced by LV-GLS and LA size across HF-stages, PALS is incrementally and independently associated with clinical status. LA function may reflect a substantial part of the hemodynamic consequences of ventricular dysfunction.
Abstract Figure 1]]></abstract><pub>Oxford University Press</pub><doi>10.1093/ehjci/jeab289.078</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-2404 |
| ispartof | European heart journal cardiovascular imaging, 2022-02, Vol.23 (Supplement_1) |
| issn | 2047-2404 2047-2412 |
| language | eng |
| recordid | cdi_crossref_primary_10_1093_ehjci_jeab289_078 |
| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Left atrial strain determinants across heart failure stages; insight from MASCOT registry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T13%3A08%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Left%20atrial%20strain%20determinants%20across%20heart%20failure%20stages;%20insight%20from%20MASCOT%20registry&rft.jtitle=European%20heart%20journal%20cardiovascular%20imaging&rft.au=Benfari,%20G&rft.date=2022-02-04&rft.volume=23&rft.issue=Supplement_1&rft.issn=2047-2404&rft.eissn=2047-2412&rft_id=info:doi/10.1093/ehjci/jeab289.078&rft_dat=%3Coup_cross%3E10.1093/ehjci/jeab289.078%3C/oup_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/ehjci/jeab289.078&rfr_iscdi=true |