Acute effects of a mavacamten-like myosin-inhibitor (MYK-581 in a feline model of obstructed hypertrophic cardiomyopathy: evidence of improved ventricular filling (beyond obstruction reprieve)

Abstract Introduction Hypertrophic cardiomyopathy (HCM) is a progressive disease characterized by cardiac remodeling, hyperdynamic contraction, and impaired ventricular filling that can lead to dynamic left-ventricular outflow-track (LVOT) obstruction and exertional intolerance. Direct myosin-inhibi...

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Veröffentlicht in:	European heart journal 2020-11, Vol.41 (Supplement_2)
Hauptverfasser:	Ferguson, B.S, Stern, J.A, Oldach, M.S, Ueda, Y, Ontiveros, E.S, Napierski, N.C, Del Rio, C.L, Harris, S.P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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