The association between anxiety measured with HADS and use of psychotropic medication among cardiac patients
Abstract Background Anxiety among cardiac patients is highly prevalent and is associated to poor outcomes. Certain types of psychotropic medication are suspected of causing adverse events in cardiac patients. However, an association between symptoms of anxiety and use of psychotropic medication amon...
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| Veröffentlicht in: | European heart journal 2020-11, Vol.41 (Supplement_2) |
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| creator | Cromhout, P.F Christensen, A.V.C Joergensen, M.B.J Ekholm, O.E Juel, K.J Svendsen, J.H.S Rasmussen, T.B.R Borregaard, B.B Mols, R.E.M Thrysoee, L.T Thorup, C.B.T Berg, S.K.B |
| description | Abstract
Background
Anxiety among cardiac patients is highly prevalent and is associated to poor outcomes. Certain types of psychotropic medication are suspected of causing adverse events in cardiac patients. However, an association between symptoms of anxiety and use of psychotropic medication among cardiac patients has not yet been established.
Purpose
The objective was to explore the association between anxiety (measured by HADS-A) and use of psychotropic medication among cardiac patients.
Methods
All study participant were identified from the DenHeart study and data were a combination of patient-reported survey data and baseline and follow-up data from Danish national registers. Information on redeemed prescriptions of psychotropic medication was obtained from The Danish National Prescription Registry. Anxiety symptoms were defined by a HADS-A score≥8. Patients were defined as users of psychotropic medication if they had redeemed at least one prescription one and three years after discharge. Psychotropic medication was classified by Anatomical Therapeutic Chemical Classification (ATC) codes.
Multiple logistic regression analysis within one year and Cox regression analysis within three year from discharge was conducted to determine the association between symptoms of anxiety and use of psychotropic medication.
Results
Among the 12,913 cardiac patients included, a total of 3231 (28%) redeemed at least one prescription of psychotropic medication within one year and 4726 (37%) within three years after discharge. The most commonly used drugs were benzodiazepines and antidepressants. Among patients using psychotropic medication 1481 (46%) had a HADS-A score ≥8. Cardiac patients with symptoms of anxiety had significantly higher odds of using psychotropic medication within one year from discharge OR 2.47 (95% CI 2.25; 2.72). The increased risk of use of psychotropic medication was confirmed with a almost two-fold risk after three years, HR 1.92 (95% CI 1.80; 2.04), Table 1.
Conclusion
Cardiac patients with symptoms of anxiety measured by HADS were significantly more likely to use psychotropic medication within one and three years after discharge than cardiac patients without symptoms of anxiety.
Table 1. Association between symptoms of anxiety and use of psychotropic medication within one and three years
OR (95% CI)i
HR (95% CI)ii
Anxiety
HADS-A ≥8
2.47 (2.25–2.72)
1.92 (1.80–2.04)
HADS-A |
| doi_str_mv | 10.1093/ehjci/ehaa946.3435 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ehjci_ehaa946_3435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ehjci/ehaa946.3435</oup_id><sourcerecordid>10.1093/ehjci/ehaa946.3435</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1255-e8567f3bb06afe9d04f188daba7b1d248c713a2516ac258e71f84a464976f5f13</originalsourceid><addsrcrecordid>eNqNkM1OwzAQhC0EEqXwApz8Aim2YzvOsSo_RULiQJG4RRt7TVy1cRSnKn17UtoH4DIrzc7M4SPknrMZZ2X-gM3ahlEBSqlnuczVBZlwJURWaqkuyYTxUmVam69rcpPSmjFmNNcTslk1SCGlaAMMIba0xmGP2FJofwIOB7pFSLseHd2HoaHL-ePH-HJ0l5BGT7t0sE0c-tgFO0ZdsKcV2Mb2m1roXQBLu9HEdki35MrDJuHd-U7J5_PTarHM3t5fXhfzt8xyoVSGRunC53XNNHgsHZOeG-OghqLmTkhjC56DUFyDFcpgwb2RILUsC-2V5_mUiNOu7WNKPfqq68MW-kPFWXXkVf3xqs68qiOvsZSdSnHX_Sf_CwhFcbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The association between anxiety measured with HADS and use of psychotropic medication among cardiac patients</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Cromhout, P.F ; Christensen, A.V.C ; Joergensen, M.B.J ; Ekholm, O.E ; Juel, K.J ; Svendsen, J.H.S ; Rasmussen, T.B.R ; Borregaard, B.B ; Mols, R.E.M ; Thrysoee, L.T ; Thorup, C.B.T ; Berg, S.K.B</creator><creatorcontrib>Cromhout, P.F ; Christensen, A.V.C ; Joergensen, M.B.J ; Ekholm, O.E ; Juel, K.J ; Svendsen, J.H.S ; Rasmussen, T.B.R ; Borregaard, B.B ; Mols, R.E.M ; Thrysoee, L.T ; Thorup, C.B.T ; Berg, S.K.B</creatorcontrib><description>Abstract
Background
Anxiety among cardiac patients is highly prevalent and is associated to poor outcomes. Certain types of psychotropic medication are suspected of causing adverse events in cardiac patients. However, an association between symptoms of anxiety and use of psychotropic medication among cardiac patients has not yet been established.
Purpose
The objective was to explore the association between anxiety (measured by HADS-A) and use of psychotropic medication among cardiac patients.
Methods
All study participant were identified from the DenHeart study and data were a combination of patient-reported survey data and baseline and follow-up data from Danish national registers. Information on redeemed prescriptions of psychotropic medication was obtained from The Danish National Prescription Registry. Anxiety symptoms were defined by a HADS-A score≥8. Patients were defined as users of psychotropic medication if they had redeemed at least one prescription one and three years after discharge. Psychotropic medication was classified by Anatomical Therapeutic Chemical Classification (ATC) codes.
Multiple logistic regression analysis within one year and Cox regression analysis within three year from discharge was conducted to determine the association between symptoms of anxiety and use of psychotropic medication.
Results
Among the 12,913 cardiac patients included, a total of 3231 (28%) redeemed at least one prescription of psychotropic medication within one year and 4726 (37%) within three years after discharge. The most commonly used drugs were benzodiazepines and antidepressants. Among patients using psychotropic medication 1481 (46%) had a HADS-A score ≥8. Cardiac patients with symptoms of anxiety had significantly higher odds of using psychotropic medication within one year from discharge OR 2.47 (95% CI 2.25; 2.72). The increased risk of use of psychotropic medication was confirmed with a almost two-fold risk after three years, HR 1.92 (95% CI 1.80; 2.04), Table 1.
Conclusion
Cardiac patients with symptoms of anxiety measured by HADS were significantly more likely to use psychotropic medication within one and three years after discharge than cardiac patients without symptoms of anxiety.
Table 1. Association between symptoms of anxiety and use of psychotropic medication within one and three years
OR (95% CI)i
HR (95% CI)ii
Anxiety
HADS-A ≥8
2.47 (2.25–2.72)
1.92 (1.80–2.04)
HADS-A <8
1.00 (reference)
1.00 (reference)
iMultiple logistic regression analysis adjusted for age, sex, TU, educational level, cohabitation status, diagnosis, smoking status, BMI iiCox regression analysis adjusted for age, sex, TU, educational level, cohabitation status, diagnosis, smoking status, BMI.
Funding Acknowledgement
Type of funding source: Foundation. Main funding source(s): Novo Nordisk Foundation</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/ehjci/ehaa946.3435</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2020-11, Vol.41 (Supplement_2)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Cromhout, P.F</creatorcontrib><creatorcontrib>Christensen, A.V.C</creatorcontrib><creatorcontrib>Joergensen, M.B.J</creatorcontrib><creatorcontrib>Ekholm, O.E</creatorcontrib><creatorcontrib>Juel, K.J</creatorcontrib><creatorcontrib>Svendsen, J.H.S</creatorcontrib><creatorcontrib>Rasmussen, T.B.R</creatorcontrib><creatorcontrib>Borregaard, B.B</creatorcontrib><creatorcontrib>Mols, R.E.M</creatorcontrib><creatorcontrib>Thrysoee, L.T</creatorcontrib><creatorcontrib>Thorup, C.B.T</creatorcontrib><creatorcontrib>Berg, S.K.B</creatorcontrib><title>The association between anxiety measured with HADS and use of psychotropic medication among cardiac patients</title><title>European heart journal</title><description>Abstract
Background
Anxiety among cardiac patients is highly prevalent and is associated to poor outcomes. Certain types of psychotropic medication are suspected of causing adverse events in cardiac patients. However, an association between symptoms of anxiety and use of psychotropic medication among cardiac patients has not yet been established.
Purpose
The objective was to explore the association between anxiety (measured by HADS-A) and use of psychotropic medication among cardiac patients.
Methods
All study participant were identified from the DenHeart study and data were a combination of patient-reported survey data and baseline and follow-up data from Danish national registers. Information on redeemed prescriptions of psychotropic medication was obtained from The Danish National Prescription Registry. Anxiety symptoms were defined by a HADS-A score≥8. Patients were defined as users of psychotropic medication if they had redeemed at least one prescription one and three years after discharge. Psychotropic medication was classified by Anatomical Therapeutic Chemical Classification (ATC) codes.
Multiple logistic regression analysis within one year and Cox regression analysis within three year from discharge was conducted to determine the association between symptoms of anxiety and use of psychotropic medication.
Results
Among the 12,913 cardiac patients included, a total of 3231 (28%) redeemed at least one prescription of psychotropic medication within one year and 4726 (37%) within three years after discharge. The most commonly used drugs were benzodiazepines and antidepressants. Among patients using psychotropic medication 1481 (46%) had a HADS-A score ≥8. Cardiac patients with symptoms of anxiety had significantly higher odds of using psychotropic medication within one year from discharge OR 2.47 (95% CI 2.25; 2.72). The increased risk of use of psychotropic medication was confirmed with a almost two-fold risk after three years, HR 1.92 (95% CI 1.80; 2.04), Table 1.
Conclusion
Cardiac patients with symptoms of anxiety measured by HADS were significantly more likely to use psychotropic medication within one and three years after discharge than cardiac patients without symptoms of anxiety.
Table 1. Association between symptoms of anxiety and use of psychotropic medication within one and three years
OR (95% CI)i
HR (95% CI)ii
Anxiety
HADS-A ≥8
2.47 (2.25–2.72)
1.92 (1.80–2.04)
HADS-A <8
1.00 (reference)
1.00 (reference)
iMultiple logistic regression analysis adjusted for age, sex, TU, educational level, cohabitation status, diagnosis, smoking status, BMI iiCox regression analysis adjusted for age, sex, TU, educational level, cohabitation status, diagnosis, smoking status, BMI.
Funding Acknowledgement
Type of funding source: Foundation. Main funding source(s): Novo Nordisk Foundation</description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkM1OwzAQhC0EEqXwApz8Aim2YzvOsSo_RULiQJG4RRt7TVy1cRSnKn17UtoH4DIrzc7M4SPknrMZZ2X-gM3ahlEBSqlnuczVBZlwJURWaqkuyYTxUmVam69rcpPSmjFmNNcTslk1SCGlaAMMIba0xmGP2FJofwIOB7pFSLseHd2HoaHL-ePH-HJ0l5BGT7t0sE0c-tgFO0ZdsKcV2Mb2m1roXQBLu9HEdki35MrDJuHd-U7J5_PTarHM3t5fXhfzt8xyoVSGRunC53XNNHgsHZOeG-OghqLmTkhjC56DUFyDFcpgwb2RILUsC-2V5_mUiNOu7WNKPfqq68MW-kPFWXXkVf3xqs68qiOvsZSdSnHX_Sf_CwhFcbQ</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Cromhout, P.F</creator><creator>Christensen, A.V.C</creator><creator>Joergensen, M.B.J</creator><creator>Ekholm, O.E</creator><creator>Juel, K.J</creator><creator>Svendsen, J.H.S</creator><creator>Rasmussen, T.B.R</creator><creator>Borregaard, B.B</creator><creator>Mols, R.E.M</creator><creator>Thrysoee, L.T</creator><creator>Thorup, C.B.T</creator><creator>Berg, S.K.B</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201101</creationdate><title>The association between anxiety measured with HADS and use of psychotropic medication among cardiac patients</title><author>Cromhout, P.F ; Christensen, A.V.C ; Joergensen, M.B.J ; Ekholm, O.E ; Juel, K.J ; Svendsen, J.H.S ; Rasmussen, T.B.R ; Borregaard, B.B ; Mols, R.E.M ; Thrysoee, L.T ; Thorup, C.B.T ; Berg, S.K.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1255-e8567f3bb06afe9d04f188daba7b1d248c713a2516ac258e71f84a464976f5f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cromhout, P.F</creatorcontrib><creatorcontrib>Christensen, A.V.C</creatorcontrib><creatorcontrib>Joergensen, M.B.J</creatorcontrib><creatorcontrib>Ekholm, O.E</creatorcontrib><creatorcontrib>Juel, K.J</creatorcontrib><creatorcontrib>Svendsen, J.H.S</creatorcontrib><creatorcontrib>Rasmussen, T.B.R</creatorcontrib><creatorcontrib>Borregaard, B.B</creatorcontrib><creatorcontrib>Mols, R.E.M</creatorcontrib><creatorcontrib>Thrysoee, L.T</creatorcontrib><creatorcontrib>Thorup, C.B.T</creatorcontrib><creatorcontrib>Berg, S.K.B</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cromhout, P.F</au><au>Christensen, A.V.C</au><au>Joergensen, M.B.J</au><au>Ekholm, O.E</au><au>Juel, K.J</au><au>Svendsen, J.H.S</au><au>Rasmussen, T.B.R</au><au>Borregaard, B.B</au><au>Mols, R.E.M</au><au>Thrysoee, L.T</au><au>Thorup, C.B.T</au><au>Berg, S.K.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between anxiety measured with HADS and use of psychotropic medication among cardiac patients</atitle><jtitle>European heart journal</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>41</volume><issue>Supplement_2</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
Background
Anxiety among cardiac patients is highly prevalent and is associated to poor outcomes. Certain types of psychotropic medication are suspected of causing adverse events in cardiac patients. However, an association between symptoms of anxiety and use of psychotropic medication among cardiac patients has not yet been established.
Purpose
The objective was to explore the association between anxiety (measured by HADS-A) and use of psychotropic medication among cardiac patients.
Methods
All study participant were identified from the DenHeart study and data were a combination of patient-reported survey data and baseline and follow-up data from Danish national registers. Information on redeemed prescriptions of psychotropic medication was obtained from The Danish National Prescription Registry. Anxiety symptoms were defined by a HADS-A score≥8. Patients were defined as users of psychotropic medication if they had redeemed at least one prescription one and three years after discharge. Psychotropic medication was classified by Anatomical Therapeutic Chemical Classification (ATC) codes.
Multiple logistic regression analysis within one year and Cox regression analysis within three year from discharge was conducted to determine the association between symptoms of anxiety and use of psychotropic medication.
Results
Among the 12,913 cardiac patients included, a total of 3231 (28%) redeemed at least one prescription of psychotropic medication within one year and 4726 (37%) within three years after discharge. The most commonly used drugs were benzodiazepines and antidepressants. Among patients using psychotropic medication 1481 (46%) had a HADS-A score ≥8. Cardiac patients with symptoms of anxiety had significantly higher odds of using psychotropic medication within one year from discharge OR 2.47 (95% CI 2.25; 2.72). The increased risk of use of psychotropic medication was confirmed with a almost two-fold risk after three years, HR 1.92 (95% CI 1.80; 2.04), Table 1.
Conclusion
Cardiac patients with symptoms of anxiety measured by HADS were significantly more likely to use psychotropic medication within one and three years after discharge than cardiac patients without symptoms of anxiety.
Table 1. Association between symptoms of anxiety and use of psychotropic medication within one and three years
OR (95% CI)i
HR (95% CI)ii
Anxiety
HADS-A ≥8
2.47 (2.25–2.72)
1.92 (1.80–2.04)
HADS-A <8
1.00 (reference)
1.00 (reference)
iMultiple logistic regression analysis adjusted for age, sex, TU, educational level, cohabitation status, diagnosis, smoking status, BMI iiCox regression analysis adjusted for age, sex, TU, educational level, cohabitation status, diagnosis, smoking status, BMI.
Funding Acknowledgement
Type of funding source: Foundation. Main funding source(s): Novo Nordisk Foundation</abstract><pub>Oxford University Press</pub><doi>10.1093/ehjci/ehaa946.3435</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| title | The association between anxiety measured with HADS and use of psychotropic medication among cardiac patients |
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