Prognostic accuracy of common heart failure scales in patients with dilated cardiomyopathy
Abstract Introduction The reliable identification of patients with heart failure (HF) and high mortality risk is crucial for treatment optimalization and prognostication, especially in younger population in dilated cardiomyopathy (DCM). However, the profile of DCM patients significantly differs from...
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| description | Abstract
Introduction
The reliable identification of patients with heart failure (HF) and high mortality risk is crucial for treatment optimalization and prognostication, especially in younger population in dilated cardiomyopathy (DCM). However, the profile of DCM patients significantly differs from the general HF population. Therefore, the applicability of commonly used HF prognostic scales may be sub-optimal in DCM.
Purpose
Comparison of the prognostic accuracy of common HF prognostic scales in DCM.
Methods
Between 2010 and 2018 we analysed 406 DCM in- and outpatients (aged 54±14 years, 76% male, NYHA: 2.5±0.9, symptoms duration: 40±58 months, EF: 26±9%, LVEDd: 66±10mm, NT-proBNP: 3662±7617pg/ml, 10% had ICD, 3.5% had CRT). The mortality risk was assessed by 8 most popular HF prognostic scores. In 2019 information on patients status were gathered after 48±32months.
Results
During first month 4 patients (1.0%) died, after 1 year – 19 (6%), 2 years – 32 (11%), 3 years – 42 (18%), 4 years – 52 (27%), 5 years – 59 (40%). BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality (Table 1).
Conclusions
Mortality risk of DCM patients during 5 years is high and reaches 40%. BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality.
Table 1. Prognostic performance of most common HF prognostic scales
AUC
95% CI
p-value
In-hospital mortality risk by OPTIMIZE-HF
0.747
0.503–0.990
0.03
1-year mortality risk by MAGGIC
0.702
0.565–0.840
0.004
1-year mortality risk by SHFM
0.808
0.682–0.934 |
| doi_str_mv | 10.1093/ehjci/ehaa946.2099 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ehjci_ehaa946_2099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ehjci/ehaa946.2099</oup_id><sourcerecordid>10.1093/ehjci/ehaa946.2099</sourcerecordid><originalsourceid>FETCH-LOGICAL-c819-b943f3cae018e4a4f0b6ba3a3de8b0679a48ef2c379f7c3951d0c41e315909b13</originalsourceid><addsrcrecordid>eNqNkL1OwzAUhS0EEqXwAkx-gRQ7dtzcEVX8SZVg6IBYopsbm7hK4spOhfL2tLQPwHLOcH6Gj7F7KRZSgHqw7Zb8QRFBm0UuAC7YTBZ5noHRxSWbCQlFZkz5ec1uUtoKIUojzYx9fcTwPYQ0euJItI9IEw-OU-j7MPDWYhy5Q9_to-WJsLOJ-4HvcPR2GBP_8WPLG9_haBtOGBsf-ikc4na6ZVcOu2Tvzj5nm-enzeo1W7-_vK0e1xmVErIatHKK0ApZWo3aidrUqFA1tqyFWQLq0rqc1BLckhQUshGkpVWyAAG1VHOWn24phpSiddUu-h7jVElRHeFUf3CqM5zqCOcwyk6jsN_9p_8LWdJrkw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Prognostic accuracy of common heart failure scales in patients with dilated cardiomyopathy</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Dziewiecka, E ; Gliniak, M ; Winiarczyk, M ; Karapetyan, A ; Wisniowska-Smialek, S ; Karabinowska, A ; Podolec, P ; Rubis, P</creator><creatorcontrib>Dziewiecka, E ; Gliniak, M ; Winiarczyk, M ; Karapetyan, A ; Wisniowska-Smialek, S ; Karabinowska, A ; Podolec, P ; Rubis, P</creatorcontrib><description><![CDATA[Abstract
Introduction
The reliable identification of patients with heart failure (HF) and high mortality risk is crucial for treatment optimalization and prognostication, especially in younger population in dilated cardiomyopathy (DCM). However, the profile of DCM patients significantly differs from the general HF population. Therefore, the applicability of commonly used HF prognostic scales may be sub-optimal in DCM.
Purpose
Comparison of the prognostic accuracy of common HF prognostic scales in DCM.
Methods
Between 2010 and 2018 we analysed 406 DCM in- and outpatients (aged 54±14 years, 76% male, NYHA: 2.5±0.9, symptoms duration: 40±58 months, EF: 26±9%, LVEDd: 66±10mm, NT-proBNP: 3662±7617pg/ml, 10% had ICD, 3.5% had CRT). The mortality risk was assessed by 8 most popular HF prognostic scores. In 2019 information on patients status were gathered after 48±32months.
Results
During first month 4 patients (1.0%) died, after 1 year – 19 (6%), 2 years – 32 (11%), 3 years – 42 (18%), 4 years – 52 (27%), 5 years – 59 (40%). BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality (Table 1).
Conclusions
Mortality risk of DCM patients during 5 years is high and reaches 40%. BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality.
Table 1. Prognostic performance of most common HF prognostic scales
AUC
95% CI
p-value
In-hospital mortality risk by OPTIMIZE-HF
0.747
0.503–0.990
0.03
1-year mortality risk by MAGGIC
0.702
0.565–0.840
0.004
1-year mortality risk by SHFM
0.808
0.682–0.934
<0.001
1-year mortality risk by BCN
0.827
0.737–0.918
<0.001
2-years mortality risk by CHARM
0.695
0.594–0.797
<0.001
2-years mortality risk by GISSI-HF
0.690
0.595–0.785
<0.001
2-years m ortality risk by SHF
0.794
0.699–0.888
<0.001
2-years mortality risk by BCN
0.830
0.762–0.897
<0.001
2-years mortality risk by EMPHASIS
0.701
0.604–0.798
<0.001
3-years mortality risk by MAGGIC
0.685
0.601–0.769
<0.001
3-years mortality risk by BCN
0.809
0.742–0.876
<0.001
4-years mortality risk by GISSI-HF
0.642
0.555–0.729
0.001
4-years mortality risk by MUSIC
0.744
0.668–0.820
<0.001
4-years mortality risk by BCN
0.808
0.742–0.873
<0.001
5-years mortality risk by SHF
0.764
0.688–0.840
<0.001
5-years mortality risk by BCN
0.792
0.725–0.860
<0.001
Funding Acknowledgement
Type of funding source: Public Institution(s). Main funding source(s): Department of Scientific Research and Structural Funds of Medical College, Jagiellonian University]]></description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/ehjci/ehaa946.2099</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2020-11, Vol.41 (Supplement_2)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids></links><search><creatorcontrib>Dziewiecka, E</creatorcontrib><creatorcontrib>Gliniak, M</creatorcontrib><creatorcontrib>Winiarczyk, M</creatorcontrib><creatorcontrib>Karapetyan, A</creatorcontrib><creatorcontrib>Wisniowska-Smialek, S</creatorcontrib><creatorcontrib>Karabinowska, A</creatorcontrib><creatorcontrib>Podolec, P</creatorcontrib><creatorcontrib>Rubis, P</creatorcontrib><title>Prognostic accuracy of common heart failure scales in patients with dilated cardiomyopathy</title><title>European heart journal</title><description><![CDATA[Abstract
Introduction
The reliable identification of patients with heart failure (HF) and high mortality risk is crucial for treatment optimalization and prognostication, especially in younger population in dilated cardiomyopathy (DCM). However, the profile of DCM patients significantly differs from the general HF population. Therefore, the applicability of commonly used HF prognostic scales may be sub-optimal in DCM.
Purpose
Comparison of the prognostic accuracy of common HF prognostic scales in DCM.
Methods
Between 2010 and 2018 we analysed 406 DCM in- and outpatients (aged 54±14 years, 76% male, NYHA: 2.5±0.9, symptoms duration: 40±58 months, EF: 26±9%, LVEDd: 66±10mm, NT-proBNP: 3662±7617pg/ml, 10% had ICD, 3.5% had CRT). The mortality risk was assessed by 8 most popular HF prognostic scores. In 2019 information on patients status were gathered after 48±32months.
Results
During first month 4 patients (1.0%) died, after 1 year – 19 (6%), 2 years – 32 (11%), 3 years – 42 (18%), 4 years – 52 (27%), 5 years – 59 (40%). BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality (Table 1).
Conclusions
Mortality risk of DCM patients during 5 years is high and reaches 40%. BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality.
Table 1. Prognostic performance of most common HF prognostic scales
AUC
95% CI
p-value
In-hospital mortality risk by OPTIMIZE-HF
0.747
0.503–0.990
0.03
1-year mortality risk by MAGGIC
0.702
0.565–0.840
0.004
1-year mortality risk by SHFM
0.808
0.682–0.934
<0.001
1-year mortality risk by BCN
0.827
0.737–0.918
<0.001
2-years mortality risk by CHARM
0.695
0.594–0.797
<0.001
2-years mortality risk by GISSI-HF
0.690
0.595–0.785
<0.001
2-years m ortality risk by SHF
0.794
0.699–0.888
<0.001
2-years mortality risk by BCN
0.830
0.762–0.897
<0.001
2-years mortality risk by EMPHASIS
0.701
0.604–0.798
<0.001
3-years mortality risk by MAGGIC
0.685
0.601–0.769
<0.001
3-years mortality risk by BCN
0.809
0.742–0.876
<0.001
4-years mortality risk by GISSI-HF
0.642
0.555–0.729
0.001
4-years mortality risk by MUSIC
0.744
0.668–0.820
<0.001
4-years mortality risk by BCN
0.808
0.742–0.873
<0.001
5-years mortality risk by SHF
0.764
0.688–0.840
<0.001
5-years mortality risk by BCN
0.792
0.725–0.860
<0.001
Funding Acknowledgement
Type of funding source: Public Institution(s). Main funding source(s): Department of Scientific Research and Structural Funds of Medical College, Jagiellonian University]]></description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkL1OwzAUhS0EEqXwAkx-gRQ7dtzcEVX8SZVg6IBYopsbm7hK4spOhfL2tLQPwHLOcH6Gj7F7KRZSgHqw7Zb8QRFBm0UuAC7YTBZ5noHRxSWbCQlFZkz5ec1uUtoKIUojzYx9fcTwPYQ0euJItI9IEw-OU-j7MPDWYhy5Q9_to-WJsLOJ-4HvcPR2GBP_8WPLG9_haBtOGBsf-ikc4na6ZVcOu2Tvzj5nm-enzeo1W7-_vK0e1xmVErIatHKK0ApZWo3aidrUqFA1tqyFWQLq0rqc1BLckhQUshGkpVWyAAG1VHOWn24phpSiddUu-h7jVElRHeFUf3CqM5zqCOcwyk6jsN_9p_8LWdJrkw</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Dziewiecka, E</creator><creator>Gliniak, M</creator><creator>Winiarczyk, M</creator><creator>Karapetyan, A</creator><creator>Wisniowska-Smialek, S</creator><creator>Karabinowska, A</creator><creator>Podolec, P</creator><creator>Rubis, P</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201101</creationdate><title>Prognostic accuracy of common heart failure scales in patients with dilated cardiomyopathy</title><author>Dziewiecka, E ; Gliniak, M ; Winiarczyk, M ; Karapetyan, A ; Wisniowska-Smialek, S ; Karabinowska, A ; Podolec, P ; Rubis, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c819-b943f3cae018e4a4f0b6ba3a3de8b0679a48ef2c379f7c3951d0c41e315909b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dziewiecka, E</creatorcontrib><creatorcontrib>Gliniak, M</creatorcontrib><creatorcontrib>Winiarczyk, M</creatorcontrib><creatorcontrib>Karapetyan, A</creatorcontrib><creatorcontrib>Wisniowska-Smialek, S</creatorcontrib><creatorcontrib>Karabinowska, A</creatorcontrib><creatorcontrib>Podolec, P</creatorcontrib><creatorcontrib>Rubis, P</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dziewiecka, E</au><au>Gliniak, M</au><au>Winiarczyk, M</au><au>Karapetyan, A</au><au>Wisniowska-Smialek, S</au><au>Karabinowska, A</au><au>Podolec, P</au><au>Rubis, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic accuracy of common heart failure scales in patients with dilated cardiomyopathy</atitle><jtitle>European heart journal</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>41</volume><issue>Supplement_2</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract><![CDATA[Abstract
Introduction
The reliable identification of patients with heart failure (HF) and high mortality risk is crucial for treatment optimalization and prognostication, especially in younger population in dilated cardiomyopathy (DCM). However, the profile of DCM patients significantly differs from the general HF population. Therefore, the applicability of commonly used HF prognostic scales may be sub-optimal in DCM.
Purpose
Comparison of the prognostic accuracy of common HF prognostic scales in DCM.
Methods
Between 2010 and 2018 we analysed 406 DCM in- and outpatients (aged 54±14 years, 76% male, NYHA: 2.5±0.9, symptoms duration: 40±58 months, EF: 26±9%, LVEDd: 66±10mm, NT-proBNP: 3662±7617pg/ml, 10% had ICD, 3.5% had CRT). The mortality risk was assessed by 8 most popular HF prognostic scores. In 2019 information on patients status were gathered after 48±32months.
Results
During first month 4 patients (1.0%) died, after 1 year – 19 (6%), 2 years – 32 (11%), 3 years – 42 (18%), 4 years – 52 (27%), 5 years – 59 (40%). BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality (Table 1).
Conclusions
Mortality risk of DCM patients during 5 years is high and reaches 40%. BCN and SHFM calculators had the best prognostic ability for 1–5 years mortality.
Table 1. Prognostic performance of most common HF prognostic scales
AUC
95% CI
p-value
In-hospital mortality risk by OPTIMIZE-HF
0.747
0.503–0.990
0.03
1-year mortality risk by MAGGIC
0.702
0.565–0.840
0.004
1-year mortality risk by SHFM
0.808
0.682–0.934
<0.001
1-year mortality risk by BCN
0.827
0.737–0.918
<0.001
2-years mortality risk by CHARM
0.695
0.594–0.797
<0.001
2-years mortality risk by GISSI-HF
0.690
0.595–0.785
<0.001
2-years m ortality risk by SHF
0.794
0.699–0.888
<0.001
2-years mortality risk by BCN
0.830
0.762–0.897
<0.001
2-years mortality risk by EMPHASIS
0.701
0.604–0.798
<0.001
3-years mortality risk by MAGGIC
0.685
0.601–0.769
<0.001
3-years mortality risk by BCN
0.809
0.742–0.876
<0.001
4-years mortality risk by GISSI-HF
0.642
0.555–0.729
0.001
4-years mortality risk by MUSIC
0.744
0.668–0.820
<0.001
4-years mortality risk by BCN
0.808
0.742–0.873
<0.001
5-years mortality risk by SHF
0.764
0.688–0.840
<0.001
5-years mortality risk by BCN
0.792
0.725–0.860
<0.001
Funding Acknowledgement
Type of funding source: Public Institution(s). Main funding source(s): Department of Scientific Research and Structural Funds of Medical College, Jagiellonian University]]></abstract><pub>Oxford University Press</pub><doi>10.1093/ehjci/ehaa946.2099</doi></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Prognostic accuracy of common heart failure scales in patients with dilated cardiomyopathy |
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