Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life
Abstract Background Pulmonary and cardiac function both decline with age. However, few data exist regarding the associations of obstructive and restrictive spirometric patterns with cardiac structure and function in late-life. Purpose Determine the associations of reduced percent predicted forced vi...
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| Veröffentlicht in: | European heart journal 2020-11, Vol.41 (Supplement_2) |
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| creator | Ramalho, S Claggett, B.L Kitzman, D.W Chang, P.P Cipriano Junior, G Solomon, S.D Skali, H.L Shah, A.M |
| description | Abstract
Background
Pulmonary and cardiac function both decline with age. However, few data exist regarding the associations of obstructive and restrictive spirometric patterns with cardiac structure and function in late-life.
Purpose
Determine the associations of reduced percent predicted forced vital capacity (ppFVC) and forced expired volume in 1 second (FEV1)/FVC with cardiac structure and function in late life.
Methods
In the Atherosclerosis Risk in Communities longitudinal cohort study, 3,854 heart failure free participants underwent echocardiography and spirometry at the fifth study visit (2011–2013). Relationships were examined using multivariable linear regression. Models adjusted for demographics and clinical risk factors (Table legend).
Results
Mean age was 75±5 years, 40% were male, 19% black, and 6% current smokers. Mean FEV1/FVC was 72±8, and ppFVC was 98±17%. In adjusted analyses, lower FEV1/FVC was associated with higher pulmonary arterial pressure (PASP) but not with measures of left ventricular (LV) structure or function (Table). In contrast, lower ppFVC, was associated with greater LV mass, worse LV strain, higher E/e' ratio, greater left atrial volume index, and higher PASP (all p |
| doi_str_mv | 10.1093/ehjci/ehaa946.0043 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ehjci_ehaa946_0043</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ehjci/ehaa946.0043</oup_id><sourcerecordid>10.1093/ehjci/ehaa946.0043</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1253-c9e4791e1bcc14957c6e459fcaa79013fe5b78d7c666a61db4586f307aba48e83</originalsourceid><addsrcrecordid>eNqNkEtOwzAQhi0EEqVwAVa-gIud2E68RBUvqVI3ILGLJs5YdRWSynaKsuLqpKQHYDOjfx7f4iPkXvCV4CZ_wN3e-qkCGKlXnMv8giyEyjJmtFSXZMGFUUzr8vOa3MS455yXWugF-dnWMYXBJn9ECl1DA07Zz_mIXfItpD6M9AApYegihYC08c5hOG2hbUcKMfbWQ8KGfvu0oxZC48HSmTyEmeyGbsL2HfUdnaDIWu_wllw5aCPenfuSfDw_va9f2Wb78rZ-3DArMpUza1AWRqCorRXSqMJqlMo4C1AYLnKHqi7KZhprDVo0tVSldjkvoAZZYpkvSTZzbehjDOiqQ_BfEMZK8OqksPpTWJ0VVieF0xObn_rh8J_7X9KVems</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ramalho, S ; Claggett, B.L ; Kitzman, D.W ; Chang, P.P ; Cipriano Junior, G ; Solomon, S.D ; Skali, H.L ; Shah, A.M</creator><creatorcontrib>Ramalho, S ; Claggett, B.L ; Kitzman, D.W ; Chang, P.P ; Cipriano Junior, G ; Solomon, S.D ; Skali, H.L ; Shah, A.M</creatorcontrib><description><![CDATA[Abstract
Background
Pulmonary and cardiac function both decline with age. However, few data exist regarding the associations of obstructive and restrictive spirometric patterns with cardiac structure and function in late-life.
Purpose
Determine the associations of reduced percent predicted forced vital capacity (ppFVC) and forced expired volume in 1 second (FEV1)/FVC with cardiac structure and function in late life.
Methods
In the Atherosclerosis Risk in Communities longitudinal cohort study, 3,854 heart failure free participants underwent echocardiography and spirometry at the fifth study visit (2011–2013). Relationships were examined using multivariable linear regression. Models adjusted for demographics and clinical risk factors (Table legend).
Results
Mean age was 75±5 years, 40% were male, 19% black, and 6% current smokers. Mean FEV1/FVC was 72±8, and ppFVC was 98±17%. In adjusted analyses, lower FEV1/FVC was associated with higher pulmonary arterial pressure (PASP) but not with measures of left ventricular (LV) structure or function (Table). In contrast, lower ppFVC, was associated with greater LV mass, worse LV strain, higher E/e' ratio, greater left atrial volume index, and higher PASP (all p<0.01; Table).
Conclusion
In late life, reductions in both FEV1/FVC and ppFVC are associated with higher pulmonary pressure, but only ppFVC was associated with worse LV structure and function.
Table 1. Cardiac metrics and Lung function
FEV1/FVC ratio
Percent predicted FVC
CARDIAC METRICS
Worst Quartile
Other Quartiles
p-value
Worst Quartile
Other Quartiles
p-value
LV mass, g
142±41
146±41
0.02
155±44
142±40
<0.001*
LVEF, %
65.8±5.9
65.9±5.9
0.76
65.7±6.1
66.0±5.8
0.16
GLS, %
−18.1±2.5
−18.2±2.4
0.26
−17.9±2.6
−18.2±2.3
<0.001*
E/e' septal
12.0±4.4
12.0±3.9
0.75
12.6±4.4
11.9±3.8
<0.001*
LAVi, mL/m2
25.3±9.7
25.5±8.2
0.17
25.9±9.1
25.3±7.8
0.01
PASP, mmHg
28.4±5.6
27.6±5.3
0.004*
28.4±6.1
27.4±5.0
<0.001*
GLS: longitudinal strain; LAVi: left atrium volume index; PASP: estimated pulmonary artery systolic pressure. P values are adjusted for age, gender, race, and the other pulmonary measure. *p<0.05 after further adjustment for body mass index, current smoking, hypertension, diabetes, log(high sensitivity C-reactive protein), log(NT-proBNP).
Funding Acknowledgement
Type of funding source: Public Institution(s). Main funding source(s): National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services]]></description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/ehjci/ehaa946.0043</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>European heart journal, 2020-11, Vol.41 (Supplement_2)</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Ramalho, S</creatorcontrib><creatorcontrib>Claggett, B.L</creatorcontrib><creatorcontrib>Kitzman, D.W</creatorcontrib><creatorcontrib>Chang, P.P</creatorcontrib><creatorcontrib>Cipriano Junior, G</creatorcontrib><creatorcontrib>Solomon, S.D</creatorcontrib><creatorcontrib>Skali, H.L</creatorcontrib><creatorcontrib>Shah, A.M</creatorcontrib><title>Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life</title><title>European heart journal</title><description><![CDATA[Abstract
Background
Pulmonary and cardiac function both decline with age. However, few data exist regarding the associations of obstructive and restrictive spirometric patterns with cardiac structure and function in late-life.
Purpose
Determine the associations of reduced percent predicted forced vital capacity (ppFVC) and forced expired volume in 1 second (FEV1)/FVC with cardiac structure and function in late life.
Methods
In the Atherosclerosis Risk in Communities longitudinal cohort study, 3,854 heart failure free participants underwent echocardiography and spirometry at the fifth study visit (2011–2013). Relationships were examined using multivariable linear regression. Models adjusted for demographics and clinical risk factors (Table legend).
Results
Mean age was 75±5 years, 40% were male, 19% black, and 6% current smokers. Mean FEV1/FVC was 72±8, and ppFVC was 98±17%. In adjusted analyses, lower FEV1/FVC was associated with higher pulmonary arterial pressure (PASP) but not with measures of left ventricular (LV) structure or function (Table). In contrast, lower ppFVC, was associated with greater LV mass, worse LV strain, higher E/e' ratio, greater left atrial volume index, and higher PASP (all p<0.01; Table).
Conclusion
In late life, reductions in both FEV1/FVC and ppFVC are associated with higher pulmonary pressure, but only ppFVC was associated with worse LV structure and function.
Table 1. Cardiac metrics and Lung function
FEV1/FVC ratio
Percent predicted FVC
CARDIAC METRICS
Worst Quartile
Other Quartiles
p-value
Worst Quartile
Other Quartiles
p-value
LV mass, g
142±41
146±41
0.02
155±44
142±40
<0.001*
LVEF, %
65.8±5.9
65.9±5.9
0.76
65.7±6.1
66.0±5.8
0.16
GLS, %
−18.1±2.5
−18.2±2.4
0.26
−17.9±2.6
−18.2±2.3
<0.001*
E/e' septal
12.0±4.4
12.0±3.9
0.75
12.6±4.4
11.9±3.8
<0.001*
LAVi, mL/m2
25.3±9.7
25.5±8.2
0.17
25.9±9.1
25.3±7.8
0.01
PASP, mmHg
28.4±5.6
27.6±5.3
0.004*
28.4±6.1
27.4±5.0
<0.001*
GLS: longitudinal strain; LAVi: left atrium volume index; PASP: estimated pulmonary artery systolic pressure. P values are adjusted for age, gender, race, and the other pulmonary measure. *p<0.05 after further adjustment for body mass index, current smoking, hypertension, diabetes, log(high sensitivity C-reactive protein), log(NT-proBNP).
Funding Acknowledgement
Type of funding source: Public Institution(s). Main funding source(s): National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services]]></description><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkEtOwzAQhi0EEqVwAVa-gIud2E68RBUvqVI3ILGLJs5YdRWSynaKsuLqpKQHYDOjfx7f4iPkXvCV4CZ_wN3e-qkCGKlXnMv8giyEyjJmtFSXZMGFUUzr8vOa3MS455yXWugF-dnWMYXBJn9ECl1DA07Zz_mIXfItpD6M9AApYegihYC08c5hOG2hbUcKMfbWQ8KGfvu0oxZC48HSmTyEmeyGbsL2HfUdnaDIWu_wllw5aCPenfuSfDw_va9f2Wb78rZ-3DArMpUza1AWRqCorRXSqMJqlMo4C1AYLnKHqi7KZhprDVo0tVSldjkvoAZZYpkvSTZzbehjDOiqQ_BfEMZK8OqksPpTWJ0VVieF0xObn_rh8J_7X9KVems</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Ramalho, S</creator><creator>Claggett, B.L</creator><creator>Kitzman, D.W</creator><creator>Chang, P.P</creator><creator>Cipriano Junior, G</creator><creator>Solomon, S.D</creator><creator>Skali, H.L</creator><creator>Shah, A.M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201101</creationdate><title>Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life</title><author>Ramalho, S ; Claggett, B.L ; Kitzman, D.W ; Chang, P.P ; Cipriano Junior, G ; Solomon, S.D ; Skali, H.L ; Shah, A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1253-c9e4791e1bcc14957c6e459fcaa79013fe5b78d7c666a61db4586f307aba48e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramalho, S</creatorcontrib><creatorcontrib>Claggett, B.L</creatorcontrib><creatorcontrib>Kitzman, D.W</creatorcontrib><creatorcontrib>Chang, P.P</creatorcontrib><creatorcontrib>Cipriano Junior, G</creatorcontrib><creatorcontrib>Solomon, S.D</creatorcontrib><creatorcontrib>Skali, H.L</creatorcontrib><creatorcontrib>Shah, A.M</creatorcontrib><collection>CrossRef</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramalho, S</au><au>Claggett, B.L</au><au>Kitzman, D.W</au><au>Chang, P.P</au><au>Cipriano Junior, G</au><au>Solomon, S.D</au><au>Skali, H.L</au><au>Shah, A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life</atitle><jtitle>European heart journal</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>41</volume><issue>Supplement_2</issue><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract><![CDATA[Abstract
Background
Pulmonary and cardiac function both decline with age. However, few data exist regarding the associations of obstructive and restrictive spirometric patterns with cardiac structure and function in late-life.
Purpose
Determine the associations of reduced percent predicted forced vital capacity (ppFVC) and forced expired volume in 1 second (FEV1)/FVC with cardiac structure and function in late life.
Methods
In the Atherosclerosis Risk in Communities longitudinal cohort study, 3,854 heart failure free participants underwent echocardiography and spirometry at the fifth study visit (2011–2013). Relationships were examined using multivariable linear regression. Models adjusted for demographics and clinical risk factors (Table legend).
Results
Mean age was 75±5 years, 40% were male, 19% black, and 6% current smokers. Mean FEV1/FVC was 72±8, and ppFVC was 98±17%. In adjusted analyses, lower FEV1/FVC was associated with higher pulmonary arterial pressure (PASP) but not with measures of left ventricular (LV) structure or function (Table). In contrast, lower ppFVC, was associated with greater LV mass, worse LV strain, higher E/e' ratio, greater left atrial volume index, and higher PASP (all p<0.01; Table).
Conclusion
In late life, reductions in both FEV1/FVC and ppFVC are associated with higher pulmonary pressure, but only ppFVC was associated with worse LV structure and function.
Table 1. Cardiac metrics and Lung function
FEV1/FVC ratio
Percent predicted FVC
CARDIAC METRICS
Worst Quartile
Other Quartiles
p-value
Worst Quartile
Other Quartiles
p-value
LV mass, g
142±41
146±41
0.02
155±44
142±40
<0.001*
LVEF, %
65.8±5.9
65.9±5.9
0.76
65.7±6.1
66.0±5.8
0.16
GLS, %
−18.1±2.5
−18.2±2.4
0.26
−17.9±2.6
−18.2±2.3
<0.001*
E/e' septal
12.0±4.4
12.0±3.9
0.75
12.6±4.4
11.9±3.8
<0.001*
LAVi, mL/m2
25.3±9.7
25.5±8.2
0.17
25.9±9.1
25.3±7.8
0.01
PASP, mmHg
28.4±5.6
27.6±5.3
0.004*
28.4±6.1
27.4±5.0
<0.001*
GLS: longitudinal strain; LAVi: left atrium volume index; PASP: estimated pulmonary artery systolic pressure. P values are adjusted for age, gender, race, and the other pulmonary measure. *p<0.05 after further adjustment for body mass index, current smoking, hypertension, diabetes, log(high sensitivity C-reactive protein), log(NT-proBNP).
Funding Acknowledgement
Type of funding source: Public Institution(s). Main funding source(s): National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services]]></abstract><pub>Oxford University Press</pub><doi>10.1093/ehjci/ehaa946.0043</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life |
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