P839 Clinical and sociodemographical characteristics of inflammatory bowel disease in Mexico: Multicentric nation-wide study (EPIMEX-IBD)

Abstract Background Despite the worldwide increasing incidence of inflammatory bowel disease (IBD), our knowledge about this disease is still limited in some regions, especially developing countries. Methods Multicentric nation-wide study. Clinical and socio-demographical characteristics of Mexican patients with histopathological diagnosis of IBD (ulcerative colitis (UC), Crohn’s disease (CD) or indeterminate colitis (IC)) from whole country were collected electronically from February to October 2017. Data were analysed using SPSS v.24. Results A total of 2645 patients were recruited: 115 paediatric (90 (78.3%) with UC, 19 (16.5%) with CD, and 6 (5.2%) with IC); 1946 adults (1590 (81.7%) with UC, 317 (16.3%) with CD, 39 (2%) with IC) and 584 elderly patients, 392 (67.1%) with UC, 165 (28.3%) with CD and 27 (4.6%) with IC. Pancolitis was the most frequent extension of UC in all age categories, 65%, 62% and 58%, respectively. Ileocolic location was the most frequent for CD, 47%, 50% and 57%, respectively. The most frequent extraintestinal manifestations were arthritis and arthralgias in the three age groups, 40.8%, 30.9% and 31.9%, respectively. In children, arthritis (p = 0.001) and sacroilitis (p = 0.029) present more frequently in CD than UC. In adults, arthritis (p = 0.003), gagrenosum pyoderma (p = 0.002) and erythema nodosum (p = 0.002) were positive more frequently in CD than UC. In elderly patients, pyoderma gangrenosum (p = 0.045), uveitis (p = 0.045) and ankylosing spondilitis (p = 0.03) were present more frequently in CD than UC. Conclusions In this first multicentric study at national level, IBD affects Mexican people without gender predominance; UC diagnosis is 5 times more frequent than CD. The most frequent extension of UC is pancolitis, the most frequent location of CD is ileocolic. According to this study, the frequency of IBD appears to have an increased in the last 17 years.