The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma
SUMMARY Methylation of cysteine dioxygenase type 1 (CDO1) gene, a tumor suppressor gene, has been studied in various cancers; however, there is no information regarding Barrett esophagus cancer. In this study, the clinical significance of CDO1 methylation in Barrett esophagus adenocarcinoma (BEA) wa...
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| Veröffentlicht in: | Diseases of the esophagus 2017-03, Vol.30 (3), p.1-9 |
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| creator | Kojima, K. Yamashita, K. Ushiku, H. Katoh, H. Ishii, S. Tanaka, T. Yokoi, K. Suzuki, M. Ooizumi, Y. Igarashi, K. Hosoda, K. Moriya, H. Mieno, H. Katada, N. Tanabe, S. Watanabe, M. |
| description | SUMMARY
Methylation of cysteine dioxygenase type 1 (CDO1) gene, a tumor suppressor gene, has been studied in various cancers; however, there is no information regarding Barrett esophagus cancer. In this study, the clinical significance of CDO1 methylation in Barrett esophagus adenocarcinoma (BEA) was clarified. CDO1 gene promoter methylation was analyzed for DNA from the patient's specimens using quantitative methylation-specific polymerase chain reaction. Thirty-eight BEA patients who underwent resection were identified between 2000 and 2014. Hypermethylation of CDO1 gene was demonstrated to be frequently recognized even at early stage in BEA by quantitative methylation-specific polymerase chain reaction. In BEA, there is a robust prognostic difference between stage I and stage II/III/IV with regard to 5-year relapse-free survival (P = 0.0016) and 5-year overall survival (P = 0.0024), and the tumor size separated by 7 cm was also a prognostic factor. There was significant difference in CDO1 gene methylation according to the tumor size (P = 0.036). BEA patients with CDO1 gene methylation were shown marginally significantly poorer prognosis (P = 0.054) than otherwise patients. In conclusion, higher CDO1 gene methylation was seen in BEA at earlier stage than in squamous cell carcinoma, and it may account for aggressive phenotype of BEA. |
| doi_str_mv | 10.1093/dote/dow001 |
| format | Article |
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Methylation of cysteine dioxygenase type 1 (CDO1) gene, a tumor suppressor gene, has been studied in various cancers; however, there is no information regarding Barrett esophagus cancer. In this study, the clinical significance of CDO1 methylation in Barrett esophagus adenocarcinoma (BEA) was clarified. CDO1 gene promoter methylation was analyzed for DNA from the patient's specimens using quantitative methylation-specific polymerase chain reaction. Thirty-eight BEA patients who underwent resection were identified between 2000 and 2014. Hypermethylation of CDO1 gene was demonstrated to be frequently recognized even at early stage in BEA by quantitative methylation-specific polymerase chain reaction. In BEA, there is a robust prognostic difference between stage I and stage II/III/IV with regard to 5-year relapse-free survival (P = 0.0016) and 5-year overall survival (P = 0.0024), and the tumor size separated by 7 cm was also a prognostic factor. There was significant difference in CDO1 gene methylation according to the tumor size (P = 0.036). BEA patients with CDO1 gene methylation were shown marginally significantly poorer prognosis (P = 0.054) than otherwise patients. In conclusion, higher CDO1 gene methylation was seen in BEA at earlier stage than in squamous cell carcinoma, and it may account for aggressive phenotype of BEA.</description><identifier>ISSN: 1120-8694</identifier><identifier>EISSN: 1442-2050</identifier><identifier>DOI: 10.1093/dote/dow001</identifier><identifier>PMID: 28184414</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Barrett Esophagus - genetics ; Barrett Esophagus - pathology ; Barrett Esophagus - surgery ; Cell Transformation, Neoplastic - genetics ; Cohort Studies ; Cysteine Dioxygenase - genetics ; Disease-Free Survival ; DNA Methylation - genetics ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagectomy - methods ; Esophagectomy - mortality ; Esophagoscopy - methods ; Female ; Genetic Predisposition to Disease - epidemiology ; Humans ; Japan ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Polymerase Chain Reaction - methods ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Statistics, Nonparametric ; Survival Analysis</subject><ispartof>Diseases of the esophagus, 2017-03, Vol.30 (3), p.1-9</ispartof><rights>International Society for Diseases of the Esophagus 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-30418b683b45c7f9fe95fa534c411a78d4c46e394e9bbd1869cc288b561685923</citedby><cites>FETCH-LOGICAL-c423t-30418b683b45c7f9fe95fa534c411a78d4c46e394e9bbd1869cc288b561685923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28184414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojima, K.</creatorcontrib><creatorcontrib>Yamashita, K.</creatorcontrib><creatorcontrib>Ushiku, H.</creatorcontrib><creatorcontrib>Katoh, H.</creatorcontrib><creatorcontrib>Ishii, S.</creatorcontrib><creatorcontrib>Tanaka, T.</creatorcontrib><creatorcontrib>Yokoi, K.</creatorcontrib><creatorcontrib>Suzuki, M.</creatorcontrib><creatorcontrib>Ooizumi, Y.</creatorcontrib><creatorcontrib>Igarashi, K.</creatorcontrib><creatorcontrib>Hosoda, K.</creatorcontrib><creatorcontrib>Moriya, H.</creatorcontrib><creatorcontrib>Mieno, H.</creatorcontrib><creatorcontrib>Katada, N.</creatorcontrib><creatorcontrib>Tanabe, S.</creatorcontrib><creatorcontrib>Watanabe, M.</creatorcontrib><title>The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma</title><title>Diseases of the esophagus</title><addtitle>Dis Esophagus</addtitle><description>SUMMARY
Methylation of cysteine dioxygenase type 1 (CDO1) gene, a tumor suppressor gene, has been studied in various cancers; however, there is no information regarding Barrett esophagus cancer. In this study, the clinical significance of CDO1 methylation in Barrett esophagus adenocarcinoma (BEA) was clarified. CDO1 gene promoter methylation was analyzed for DNA from the patient's specimens using quantitative methylation-specific polymerase chain reaction. Thirty-eight BEA patients who underwent resection were identified between 2000 and 2014. Hypermethylation of CDO1 gene was demonstrated to be frequently recognized even at early stage in BEA by quantitative methylation-specific polymerase chain reaction. In BEA, there is a robust prognostic difference between stage I and stage II/III/IV with regard to 5-year relapse-free survival (P = 0.0016) and 5-year overall survival (P = 0.0024), and the tumor size separated by 7 cm was also a prognostic factor. There was significant difference in CDO1 gene methylation according to the tumor size (P = 0.036). BEA patients with CDO1 gene methylation were shown marginally significantly poorer prognosis (P = 0.054) than otherwise patients. In conclusion, higher CDO1 gene methylation was seen in BEA at earlier stage than in squamous cell carcinoma, and it may account for aggressive phenotype of BEA.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Barrett Esophagus - genetics</subject><subject>Barrett Esophagus - pathology</subject><subject>Barrett Esophagus - surgery</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cohort Studies</subject><subject>Cysteine Dioxygenase - genetics</subject><subject>Disease-Free Survival</subject><subject>DNA Methylation - genetics</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - methods</subject><subject>Esophagectomy - mortality</subject><subject>Esophagoscopy - methods</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Humans</subject><subject>Japan</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><subject>Survival Analysis</subject><issn>1120-8694</issn><issn>1442-2050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EoqUwsSNPLChgx07qjFDxJVViKXPkOM-JUWJHsSvIv8dVgJHl3TscXekdhC4puaWkYHe1CxDPJyH0CC0p52mSkowcx05Tkoi84At05v1HBNYsF6dokQoqOKd8idpdC1h1xholO-xNY42O1SrATmM1-QDGAq6N-5oasNIDDtMAmOIeQjt1MhhnsbH4QY4jhIDBu6GVzd5jWYN1So7KWNfLc3SiZefh4idX6P3pcbd5SbZvz6-b-22ieMpCwginosoFq3im1rrQUGRaZowrTqlcizqWHFjBoaiqmsbnlEqFqLKc5iIrUrZCN_OuGp33I-hyGE0vx6mkpDz4Kg--ytlXpK9methXPdR_7K-gCFzPgNsP_y59A3qJdg4</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Kojima, K.</creator><creator>Yamashita, K.</creator><creator>Ushiku, H.</creator><creator>Katoh, H.</creator><creator>Ishii, S.</creator><creator>Tanaka, T.</creator><creator>Yokoi, K.</creator><creator>Suzuki, M.</creator><creator>Ooizumi, Y.</creator><creator>Igarashi, K.</creator><creator>Hosoda, K.</creator><creator>Moriya, H.</creator><creator>Mieno, H.</creator><creator>Katada, N.</creator><creator>Tanabe, S.</creator><creator>Watanabe, M.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170301</creationdate><title>The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma</title><author>Kojima, K. ; Yamashita, K. ; Ushiku, H. ; Katoh, H. ; Ishii, S. ; Tanaka, T. ; Yokoi, K. ; Suzuki, M. ; Ooizumi, Y. ; Igarashi, K. ; Hosoda, K. ; Moriya, H. ; Mieno, H. ; Katada, N. ; Tanabe, S. ; Watanabe, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-30418b683b45c7f9fe95fa534c411a78d4c46e394e9bbd1869cc288b561685923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Barrett Esophagus - genetics</topic><topic>Barrett Esophagus - pathology</topic><topic>Barrett Esophagus - surgery</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cohort Studies</topic><topic>Cysteine Dioxygenase - genetics</topic><topic>Disease-Free Survival</topic><topic>DNA Methylation - genetics</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - methods</topic><topic>Esophagectomy - mortality</topic><topic>Esophagoscopy - methods</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Humans</topic><topic>Japan</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kojima, K.</creatorcontrib><creatorcontrib>Yamashita, K.</creatorcontrib><creatorcontrib>Ushiku, H.</creatorcontrib><creatorcontrib>Katoh, H.</creatorcontrib><creatorcontrib>Ishii, S.</creatorcontrib><creatorcontrib>Tanaka, T.</creatorcontrib><creatorcontrib>Yokoi, K.</creatorcontrib><creatorcontrib>Suzuki, M.</creatorcontrib><creatorcontrib>Ooizumi, Y.</creatorcontrib><creatorcontrib>Igarashi, K.</creatorcontrib><creatorcontrib>Hosoda, K.</creatorcontrib><creatorcontrib>Moriya, H.</creatorcontrib><creatorcontrib>Mieno, H.</creatorcontrib><creatorcontrib>Katada, N.</creatorcontrib><creatorcontrib>Tanabe, S.</creatorcontrib><creatorcontrib>Watanabe, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Diseases of the esophagus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kojima, K.</au><au>Yamashita, K.</au><au>Ushiku, H.</au><au>Katoh, H.</au><au>Ishii, S.</au><au>Tanaka, T.</au><au>Yokoi, K.</au><au>Suzuki, M.</au><au>Ooizumi, Y.</au><au>Igarashi, K.</au><au>Hosoda, K.</au><au>Moriya, H.</au><au>Mieno, H.</au><au>Katada, N.</au><au>Tanabe, S.</au><au>Watanabe, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma</atitle><jtitle>Diseases of the esophagus</jtitle><addtitle>Dis Esophagus</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>30</volume><issue>3</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1120-8694</issn><eissn>1442-2050</eissn><abstract>SUMMARY
Methylation of cysteine dioxygenase type 1 (CDO1) gene, a tumor suppressor gene, has been studied in various cancers; however, there is no information regarding Barrett esophagus cancer. In this study, the clinical significance of CDO1 methylation in Barrett esophagus adenocarcinoma (BEA) was clarified. CDO1 gene promoter methylation was analyzed for DNA from the patient's specimens using quantitative methylation-specific polymerase chain reaction. Thirty-eight BEA patients who underwent resection were identified between 2000 and 2014. Hypermethylation of CDO1 gene was demonstrated to be frequently recognized even at early stage in BEA by quantitative methylation-specific polymerase chain reaction. In BEA, there is a robust prognostic difference between stage I and stage II/III/IV with regard to 5-year relapse-free survival (P = 0.0016) and 5-year overall survival (P = 0.0024), and the tumor size separated by 7 cm was also a prognostic factor. There was significant difference in CDO1 gene methylation according to the tumor size (P = 0.036). BEA patients with CDO1 gene methylation were shown marginally significantly poorer prognosis (P = 0.054) than otherwise patients. In conclusion, higher CDO1 gene methylation was seen in BEA at earlier stage than in squamous cell carcinoma, and it may account for aggressive phenotype of BEA.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>28184414</pmid><doi>10.1093/dote/dow001</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Aged Aged, 80 and over Barrett Esophagus - genetics Barrett Esophagus - pathology Barrett Esophagus - surgery Cell Transformation, Neoplastic - genetics Cohort Studies Cysteine Dioxygenase - genetics Disease-Free Survival DNA Methylation - genetics Esophageal Neoplasms - genetics Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagectomy - methods Esophagectomy - mortality Esophagoscopy - methods Female Genetic Predisposition to Disease - epidemiology Humans Japan Kaplan-Meier Estimate Male Middle Aged Polymerase Chain Reaction - methods Prognosis Proportional Hazards Models Retrospective Studies Risk Assessment Statistics, Nonparametric Survival Analysis |
| title | The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma |
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