Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches

Transient receptor potential cation channel subfamily melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel abundantly expressed in the heart, has been implicated in conduction block and other arrhythmic propensities associated with cardiac remodelling and injury. The present stu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cardiovascular research 2017-08, Vol.113 (10), p.1243-1255
Hauptverfasser:	Hu, Yaopeng, Duan, Yubin, Takeuchi, Ayako, Hai-Kurahara, Lin, Ichikawa, Jun, Hiraishi, Keizo, Numata, Tomohiro, Ohara, Hiroki, Iribe, Gentaro, Nakaya, Michio, Mori, Masayuki X, Matsuoka, Satoshi, Ma, Genshan, Inoue, Ryuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Angiotensin II - pharmacology Animals Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Calcium Signaling Computer Simulation Heart Atria - drug effects Heart Atria - metabolism Heart Atria - physiopathology Heart Rate - drug effects HEK293 Cells Humans Kinetics Mice Models, Cardiovascular Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Numerical Analysis, Computer-Assisted Patch-Clamp Techniques Refractory Period, Electrophysiological TRPM Cation Channels - genetics TRPM Cation Channels - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!