Sample Multiplexing: Increased Throughput for Quantification of Total Testosterone in Serum by Liquid Chromatography-Tandem Mass Spectrometry

Abstract BACKGROUND For high-volume assays, optimizing throughput reduces test cost and turn-around time. One approach for liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays is sample multiplexing, wherein the analyte of interest is derivatized in different specimens with reagents of d...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2020-09, Vol.66 (9), p.1181-1189
Hauptverfasser:	Colletti, Julia D, Redor-Goldman, Mildred M, Pomperada, Agustin E, Ghoshal, Amit K, Wu, William W, McPhaul, Michael J, Clarke, Nigel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Assaying Chromatography Chromatography, Liquid - methods Humans Hydroxides Hydroxylamine Life Sciences & Biomedicine Linearity Liquid chromatography Marking Mass spectrometry Mass spectroscopy Medical Laboratory Technology Molecular weight Multiplexing Quality control Reagents Science & Technology Scientific imaging Spectroscopy Spectrum analysis Tandem Mass Spectrometry - methods Testosterone Testosterone - blood
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