Loss of FBP1 facilitates aggressive features of hepatocellular carcinoma cells through the Warburg effect

Reprogrammed metabolism has been identified as an emerging hallmark in cancer cells. It has been demonstrated that fructose-1, 6-bisphosphatase 1 (FBP1) as a rate-limiting enzyme in gluconeogenesis plays critical roles in tumor initiation and progression in several cancer types. However, function of...

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Veröffentlicht in:	Carcinogenesis (New York) 2017-02, Vol.38 (2), p.134
Hauptverfasser:	Yang, Juan, Wang, Cun, Zhao, Fengbo, Luo, Xiaoying, Qin, Meilin, Arunachalam, Einthavy, Ge, Zhouhong, Wang, Ning, Deng, Xuan, Jin, Guangzhi, Cong, Wenming, Qin, Wenxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics Disease Progression DNA Helicases - antagonists & inhibitors DNA Helicases - genetics DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics Gene Expression Regulation, Neoplastic Gene Silencing Gluconeogenesis - drug effects Gluconeogenesis - genetics Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Mice Naphthalenes - administration & dosage Neoplasm Metastasis Xenograft Model Antitumor Assays
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