Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men

The cell adhesion molecule E-cadherin has critical functions in development and carcinogenesis. Impaired expression of E-cadherin has been associated with disrupted tissue homeostasis, progression of cancer and a worse patient prognosis. So far, the role of E-cadherin in homeostasis and carcinogenes...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-08, Vol.35 (8), p.1855-1862
Hauptverfasser:	Schneider, Marlon R, Hiltwein, Felix, Grill, Jessica, Blum, Helmut, Krebs, Stefan, Klanner, Andrea, Bauersachs, Stefan, Bruns, Christiane, Longerich, Thomas, Horst, David, Brandl, Lydia, de Toni, Enrico, Herbst, Andreas, Kolligs, Frank T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Cadherins - genetics Cadherins - metabolism Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - prevention & control Cdh1 Proteins - physiology Cell Proliferation Female Humans Immunoenzyme Techniques Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - prevention & control Liver Regeneration Male Mice Mice, Inbred C57BL Mice, Knockout Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured
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