GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer

There is a need for exploration of new therapeutic strategies that target distinct molecular mechanisms of castration-resistant prostate cancer (CRPC) because its emergence following androgen deprivation therapy is a major clinical problem. In this report, we investigated the role of glutathione per...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-09, Vol.35 (9), p.1962-1967
Hauptverfasser:	Naiki, Taku, Naiki-Ito, Aya, Asamoto, Makoto, Kawai, Noriyasu, Tozawa, Keiichi, Etani, Toshiki, Sato, Shinya, Suzuki, Shugo, Shirai, Tomoyuki, Kohri, Kenjiro, Takahashi, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - enzymology Adenocarcinoma - mortality Adenocarcinoma - pathology Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Animals Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Cell Line, Tumor Cell Proliferation Disease-Free Survival Drug Resistance, Neoplasm Gene Expression Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Humans Male Mice Mice, Nude Multivariate Analysis Neoplasm Transplantation Neoplasm, Residual Prognosis Proportional Hazards Models Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - enzymology Prostatic Neoplasms, Castration-Resistant - mortality Prostatic Neoplasms, Castration-Resistant - pathology Rats Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - genetics
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