IRF5 is a target of BCR-ABL kinase activity and reduces CML cell proliferation

Interferon regulatory factor 5 (IRF5) modulates the expression of genes controlling cell growth and apoptosis. Previous findings have suggested a lack of IRF5 transcripts in both acute and chronic leukemias. However, to date, IRF5 expression and function have not been investigated in chronic myeloid...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-05, Vol.35 (5), p.1132-1143
Hauptverfasser:	Massimino, Michele, Consoli, Maria Letizia, Mesuraca, Maria, Stagno, Fabio, Tirrò, Elena, Stella, Stefania, Pennisi, Maria Stella, Romano, Chiara, Buffa, Pietro, Bond, Heather M., Morrone, Giovanni, Sciacca, Laura, Di Raimondo, Francesco, Manzella, Livia, Vigneri, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - pharmacology Benzamides - toxicity Catalysis Cell Line, Tumor Cell Proliferation Etoposide - pharmacology Etoposide - toxicity Extracellular Signal-Regulated MAP Kinases - metabolism Fusion Proteins, bcr-abl - metabolism Humans Imatinib Mesylate Interferon Regulatory Factors - metabolism Interferon-alpha - pharmacology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Phosphorylation Piperazines - pharmacology Piperazines - toxicity Protein Binding Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Pyrimidines - pharmacology Pyrimidines - toxicity Signal Transduction - drug effects Transcriptional Activation Tumor Stem Cell Assay
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