Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

Gain-of-function missense mutations of voltage-gated sodium channel NaV1.7 have been linked to the painful disorder inherited erythromelalgia. These mutations hyperpolarize activation, slow deactivation and enhance currents evoked by slow ramp stimuli (ramp currents). A correlation has recently been...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2011-07, Vol.134 (7), p.1972-1986
Hauptverfasser:	Cheng, Xiaoyang, Dib-Hajj, Sulayman D., Tyrrell, Lynda, te Morsche, Rene H., Drenth, Joost P. H., Waxman, Stephen G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Neurology Traumas. Diseases due to physical agents
Online-Zugang:	Volltext
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