$Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass$

Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass

High-dose heparin is used during cardiopulmonary bypass (CPB) to prevent thrombosis in the circuits used for extracorporeal circulation. The aim of this study was, initially, to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model to assess the variability of PK/PD parameters and their...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2017-05, Vol.118 (5), p.705-712
Hauptverfasser:	Delavenne, X., Ollier, E., Chollet, S., Sandri, F., Lanoiselée, J., Hodin, S., Montmartin, A., Fuzellier, J.-F., Mismetti, P., Gergelé, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Aged Aged, 80 and over Anticoagulants - administration & dosage Anticoagulants - pharmacokinetics Bayes Theorem biological hemostatics blood coagulation tests Body Weight Cardiopulmonary Bypass - methods cardiopulmonary bypass models Factor Xa Female heparin Heparin - administration & dosage Heparin - pharmacokinetics Humans Linear Models Male Middle Aged Prospective Studies Thrombosis - prevention & control Whole Blood Coagulation Time
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