Predictors for postoperative nausea and vomiting after xenon-based anaesthesia
In contrast to volatile anaesthetics, xenon acts by antagonism at N-methyl-d-aspartate receptors and antagonizes 5-hydroxytryptamine type 3 receptors that mediate nausea and vomiting. Therefore, it is unknown whether the same risk factors for postoperative nausea and vomiting (PONV) after volatile a...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2015-07, Vol.115 (1), p.61-67 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | Schaefer, M.S. Apfel, C.C. Sachs, H.-J. Stuttmann, R. Bein, B. Tonner, P.H. Hein, M. Neukirchen, M. Reyle-Hahn, M. Kienbaum, P. |
| description | In contrast to volatile anaesthetics, xenon acts by antagonism at N-methyl-d-aspartate receptors and antagonizes 5-hydroxytryptamine type 3 receptors that mediate nausea and vomiting. Therefore, it is unknown whether the same risk factors for postoperative nausea and vomiting (PONV) after volatile anaesthetics apply to xenon-based anaesthesia.
With ethics committee approval and written informed consent, 502 consecutive patients undergoing xenon-based anaesthesia were included in a multicentre prospective observational study. Antiemetic prophylaxis was administered at the discretion of the attending anaesthetists. Postoperative nausea and vomiting and need for antiemetic rescue medication were assessed for 24 h after anaesthesia. Multivariate logistic regression analysis was performed to quantify risk factors for PONV and need for rescue medication.
Four hundred and eighty-eight subjects were available for the final analysis. The incidence of PONV in subjects without prophylaxis was lower than expected according to the Apfel Score (28% observed; 42% expected, P |
| doi_str_mv | 10.1093/bja/aev115 |
| format | Article |
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With ethics committee approval and written informed consent, 502 consecutive patients undergoing xenon-based anaesthesia were included in a multicentre prospective observational study. Antiemetic prophylaxis was administered at the discretion of the attending anaesthetists. Postoperative nausea and vomiting and need for antiemetic rescue medication were assessed for 24 h after anaesthesia. Multivariate logistic regression analysis was performed to quantify risk factors for PONV and need for rescue medication.
Four hundred and eighty-eight subjects were available for the final analysis. The incidence of PONV in subjects without prophylaxis was lower than expected according to the Apfel Score (28% observed; 42% expected, P<0.001). Independent predictors for PONV were (adjusted odds ratio; 95% confidence interval) female sex (1.76; 1.08–2.89), younger patient age (0.82 per 10 yr; 0.69–0.97), and longer duration of anaesthesia (1.36 per hour; 1.17–1.59).
The incidence of PONV was significantly lower than predicted by the Apfel Score. Female sex, younger age, and longer duration of anaesthesia are risk factors for PONV after xenon-based anaesthesia.
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With ethics committee approval and written informed consent, 502 consecutive patients undergoing xenon-based anaesthesia were included in a multicentre prospective observational study. Antiemetic prophylaxis was administered at the discretion of the attending anaesthetists. Postoperative nausea and vomiting and need for antiemetic rescue medication were assessed for 24 h after anaesthesia. Multivariate logistic regression analysis was performed to quantify risk factors for PONV and need for rescue medication.
Four hundred and eighty-eight subjects were available for the final analysis. The incidence of PONV in subjects without prophylaxis was lower than expected according to the Apfel Score (28% observed; 42% expected, P<0.001). Independent predictors for PONV were (adjusted odds ratio; 95% confidence interval) female sex (1.76; 1.08–2.89), younger patient age (0.82 per 10 yr; 0.69–0.97), and longer duration of anaesthesia (1.36 per hour; 1.17–1.59).
The incidence of PONV was significantly lower than predicted by the Apfel Score. Female sex, younger age, and longer duration of anaesthesia are risk factors for PONV after xenon-based anaesthesia.
German Federal Institute for Drugs and Medical Devices number AL-PMS-01/07GER.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>anaesthetics</subject><subject>Anesthetics, Inhalation - adverse effects</subject><subject>antiemetics</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Nausea and Vomiting - chemically induced</subject><subject>Postoperative Nausea and Vomiting - epidemiology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Xenon - adverse effects</subject><subject>Young Adult</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rp68QdIL16Eupk2_TrK4heIetBzmSQTzeI2JckW_fdWqp7E0zDM874wD2PHwM-BN_lSrnGJNAAUO2wOooK0rCrYZXPOeZXyBrIZOwhhzTlUWVPss1lWNGVWQjZn94-etFXR-ZAY55Peheh68hjtQEmH20CYYKeTwW1stN1LgiaST96pc10qMZAez0ghvlKweMj2DL4FOvqeC_Z8dfm0uknvHq5vVxd3qcrLIqZSkKlzaKQEyU3BFTZyXDTlJDQqpUWm6qJqeA2mFLLKDaFBkwtZC8wM5At2NvUq70LwZNre2w36jxZ4-yWlHaW0k5QRPpngfis3pH_RHwsjcDoBbtv_XyQmjsbXBku-DcpSp0aDnlRstbN_xT4BY-1_cw</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Schaefer, M.S.</creator><creator>Apfel, C.C.</creator><creator>Sachs, H.-J.</creator><creator>Stuttmann, R.</creator><creator>Bein, B.</creator><creator>Tonner, P.H.</creator><creator>Hein, M.</creator><creator>Neukirchen, M.</creator><creator>Reyle-Hahn, M.</creator><creator>Kienbaum, P.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201507</creationdate><title>Predictors for postoperative nausea and vomiting after xenon-based anaesthesia</title><author>Schaefer, M.S. ; Apfel, C.C. ; Sachs, H.-J. ; Stuttmann, R. ; Bein, B. ; Tonner, P.H. ; Hein, M. ; Neukirchen, M. ; Reyle-Hahn, M. ; Kienbaum, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-b4ef8319bb1b0f50ca9b9bbde3e4daccd42c8579081f64b73feafaf34b84a2f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>anaesthetics</topic><topic>Anesthetics, Inhalation - adverse effects</topic><topic>antiemetics</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Nausea and Vomiting - chemically induced</topic><topic>Postoperative Nausea and Vomiting - epidemiology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>Xenon - adverse effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schaefer, M.S.</creatorcontrib><creatorcontrib>Apfel, C.C.</creatorcontrib><creatorcontrib>Sachs, H.-J.</creatorcontrib><creatorcontrib>Stuttmann, R.</creatorcontrib><creatorcontrib>Bein, B.</creatorcontrib><creatorcontrib>Tonner, P.H.</creatorcontrib><creatorcontrib>Hein, M.</creatorcontrib><creatorcontrib>Neukirchen, M.</creatorcontrib><creatorcontrib>Reyle-Hahn, M.</creatorcontrib><creatorcontrib>Kienbaum, P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaefer, M.S.</au><au>Apfel, C.C.</au><au>Sachs, H.-J.</au><au>Stuttmann, R.</au><au>Bein, B.</au><au>Tonner, P.H.</au><au>Hein, M.</au><au>Neukirchen, M.</au><au>Reyle-Hahn, M.</au><au>Kienbaum, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors for postoperative nausea and vomiting after xenon-based anaesthesia</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>2015-07</date><risdate>2015</risdate><volume>115</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><abstract>In contrast to volatile anaesthetics, xenon acts by antagonism at N-methyl-d-aspartate receptors and antagonizes 5-hydroxytryptamine type 3 receptors that mediate nausea and vomiting. Therefore, it is unknown whether the same risk factors for postoperative nausea and vomiting (PONV) after volatile anaesthetics apply to xenon-based anaesthesia.
With ethics committee approval and written informed consent, 502 consecutive patients undergoing xenon-based anaesthesia were included in a multicentre prospective observational study. Antiemetic prophylaxis was administered at the discretion of the attending anaesthetists. Postoperative nausea and vomiting and need for antiemetic rescue medication were assessed for 24 h after anaesthesia. Multivariate logistic regression analysis was performed to quantify risk factors for PONV and need for rescue medication.
Four hundred and eighty-eight subjects were available for the final analysis. The incidence of PONV in subjects without prophylaxis was lower than expected according to the Apfel Score (28% observed; 42% expected, P<0.001). Independent predictors for PONV were (adjusted odds ratio; 95% confidence interval) female sex (1.76; 1.08–2.89), younger patient age (0.82 per 10 yr; 0.69–0.97), and longer duration of anaesthesia (1.36 per hour; 1.17–1.59).
The incidence of PONV was significantly lower than predicted by the Apfel Score. Female sex, younger age, and longer duration of anaesthesia are risk factors for PONV after xenon-based anaesthesia.
German Federal Institute for Drugs and Medical Devices number AL-PMS-01/07GER.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25962612</pmid><doi>10.1093/bja/aev115</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over anaesthetics Anesthetics, Inhalation - adverse effects antiemetics Female Germany - epidemiology Humans Incidence Male Middle Aged Postoperative Nausea and Vomiting - chemically induced Postoperative Nausea and Vomiting - epidemiology Prospective Studies Risk Factors Sex Factors Time Factors Xenon - adverse effects Young Adult |
| title | Predictors for postoperative nausea and vomiting after xenon-based anaesthesia |
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