Deep learning identifies explainable reasoning paths of mechanism of action for drug repurposing from multilayer biological network

The discovery and repurposing of drugs require a deep understanding of the mechanism of drug action (MODA). Existing computational methods mainly model MODA with the protein-protein interaction (PPI) network. However, the molecular interactions of drugs in the human body are far beyond PPIs. Additio...

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Veröffentlicht in:	Briefings in bioinformatics 2022-11, Vol.23 (6)
Hauptverfasser:	Yang, Jiannan, Li, Zhen, Wu, William Ka Kei, Yu, Shi, Xu, Zhongzhi, Chu, Qian, Zhang, Qingpeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Artificial Intelligence Deep Learning Drug Repositioning - methods Humans Proteins - chemistry
Online-Zugang:	Volltext
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