H - 14 Psychometric Properties of the Clinical Dementia Rating (CDR) Scale in Hispanic-Latinx Communities: a Systematic Review

Abstract Objective To systematically review the literature on the psychometric properties of the Clinical Dementia Rating (CDR) scale among Hispanic-Latinx communities. Data Selection We searched multiple cross-disciplinary databases from January 1970 until April 2023 for relevant papers written in English and Spanish. We used the following terms: (1) Clinical Dementia Rating, (2) validity, (3) reliability, (4) psychometric, (5) Hispanic, (6) Latinos or Latinx, (7) outcome measures, (8) Spanish language, and (9) Alzheimer’s disease. Data Synthesis We found 609 studies with 56 eligible studies. Only 5 studies examined psychometric properties of the CDR in Hispanic-Latinx communities. Each study implemented divergent study designs. Of the 5 selected studies, one study evaluated the validity of the CDR Sum of Boxes among 1073 Mexican Americans. A second study evaluated the CDR’s test–retest reliability and internal consistency among 94 Spanish speaking participants from the United States. The third study examined the validity of the CDR Sum of Boxes among 343 Brazilians living in Brazil. A fourth study assessed the CDR Sum of Boxes sensitivity and specificity among 407 Brazilians living in Brazil, whereas a fifth study evaluated the validity of a Portuguese CDR version on 424 Brazilians living in Brazil. Conclusions Our systematic review revealed limited studies examining the validation of the CDR in the Hispanic-Latinx communities. The limited number of studies raises concerns about versions of the CDR scale implemented in ad clinical trials, and its implications to study results, interpretation, and generalizability of findings.