Phase II study of high-sensitivity genotyping of KRAS, NRAS, BRAF and PIK3CA to ultra-select metastatic colorectal cancer patients for panitumumab plus FOLFIRI: the ULTRA trial

Several studies show the importance of accurately quantifying not only KRAS and other low-abundant mutations because benefits of anti-EGFR therapies may depend on certain sensitivity thresholds. We assessed whether ultra-selection of patients using a high-sensitive digital PCR (dPCR) to determine KR...

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Veröffentlicht in:	Annals of oncology 2019-05, Vol.30 (5), p.796-803
Hauptverfasser:	Santos, C., Azuara, D., Viéitez, J.M., Páez, D., Falcó, E., Élez, E., López-López, C., Valladares, M., Robles-Díaz, L., García-Alfonso, P., Bugés, C., Durán, G., Salud, A., Navarro, V., Capellá, G., Aranda, E., Salazar, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Camptothecin - administration & dosage Camptothecin - analogs & derivatives Class I Phosphatidylinositol 3-Kinases - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology digital PCR Fluorouracil - administration & dosage FOLFIRI Genotype GTP Phosphohydrolases - genetics Humans Leucovorin - administration & dosage Male Membrane Proteins - genetics metastatic colorectal cancer Middle Aged Neoplasm Metastasis panitumumab Panitumumab - administration & dosage patient selection PCR Prospective Studies Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Survival Rate
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