$Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer$

Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer

Targeted therapy options in HER2-negative breast cancer are limited. This open-label, multicenter phase IB dose-escalation trial was conducted to determine safety, tolerability, and antitumor activity of a combination of docetaxel (Taxotere) and increasing doses of adecatumumab, a human IgG1 antibod...

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Veröffentlicht in:	Annals of oncology 2012-09, Vol.23 (9), p.2306-2313
Hauptverfasser:	Schmidt, M., Rüttinger, D., Sebastian, M., Hanusch, C.A., Marschner, N., Baeuerle, P.A., Wolf, A., Göppel, G., Oruzio, D., Schlimok, G., Steger, G.G., Wolf, C., Eiermann, W., Lang, A., Schuler, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adecatumumab Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Antigens, Neoplasm - metabolism Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion Molecules - administration & dosage Cell Adhesion Molecules - metabolism Docetaxel Drug Administration Schedule Drug Resistance, Neoplasm EpCAM Epithelial Cell Adhesion Molecule Female Gynecology. Andrology. Obstetrics Humans Leukocyte Disorders - chemically induced Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - secondary Mammary gland diseases Medical sciences metastatic breast cancer Middle Aged MT201 Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Pharmacology. Drug treatments Taxoids - administration & dosage Treatment Outcome Tumors
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