The influence of platinum pathway polymorphisms on the outcome in patients with malignant mesothelioma

Platinum-based therapy is widely used in the treatment of malignant mesothelioma (MM); however, the efficacy and toxicity of platinum agents vary greatly between patients. The aim of our study was to evaluate the influence of platinum pathway polymorphisms on treatment outcome in patients with MM. I...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of oncology 2012-04, Vol.23 (4), p.961-967
Hauptverfasser:	Erčulj, N., Kovač, V., Hmeljak, J., Dolžan, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alopecia - chemically induced Alopecia - genetics Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carboplatin - administration & dosage Cisplatin - administration & dosage Disease-Free Survival DNA Repair - genetics DNA repair polymorphisms DNA-Binding Proteins - genetics Endonucleases - genetics Female Genetic Association Studies glutathione S-transferases Glutathione Transferase - genetics Haplotypes Humans Leukopenia - chemically induced Leukopenia - genetics Male malignant mesothelioma Medical sciences Mesothelioma - drug therapy Mesothelioma - genetics Mesothelioma - mortality Middle Aged Nausea - chemically induced Nausea - genetics pharmacogenetics Pharmacology. Drug treatments platinum Polymorphism, Genetic Proportional Hazards Models Sequence Analysis, DNA Thrombocytopenia - chemically induced Thrombocytopenia - genetics Treatment Outcome Xeroderma Pigmentosum Group D Protein - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!