Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial

Background: Oral capecitabine achieves a superior response rate with an improved safety profile compared with bolus 5-fluorouracil–leucovorin (5-FU/LV) as first-line treatment for patients with metastatic colorectal cancer. We report here the results of a large phase III trial investigating adjuvant...

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Veröffentlicht in:	Annals of oncology 2003-12, Vol.14 (12), p.1735-1743
Hauptverfasser:	Scheithauer, W., McKendrick, J., Begbie, S., Borner, M., Burns, W. I., Burris, H. A., Cassidy, J., Jodrell, D., Koralewski, P., Levine, E. L., Marschner, N., Maroun, J., Garcia-Alfonso, P., Tujakowski, J., Van Hazel, G., Wong, A., Zaluski, J., Twelves, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Age Factors Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Capecitabine Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Diarrhea - chemically induced Female Fluorouracil - administration & dosage Humans Leucovorin - administration & dosage Male Medical sciences Middle Aged Neoplasm Metastasis Neutropenia - chemically induced Peripheral Nervous System Diseases - chemically induced Pharmacology. Drug treatments Safety
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