Phase II study of flavopiridol in patients with advanced colorectal cancer

Background: Flavopiridol, a synthetic flavone that inhibits cell cycle progression, has demonstrated activity in colon cancer in xenografts and in a phase I trial. We evaluated flavopiridol in a phase II trial in patients with previously untreated advanced colorectal cancer (ACRC). Patients and meth...

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Veröffentlicht in:	Annals of oncology 2003-08, Vol.14 (8), p.1270-1273
Hauptverfasser:	Aklilu, M., Kindler, H. L., Donehower, R. C., Mani, S., Vokes, E. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Biological and medical sciences Chemotherapy colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Confidence Intervals Dose-Response Relationship, Drug Drug Administration Schedule Female Flavonoids - administration & dosage Flavonoids - adverse effects flavopiridol Follow-Up Studies Humans Infusions, Intravenous Key words: clinical trial Magnetic Resonance Imaging Male Maximum Tolerated Dose Medical sciences Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Pharmacology. Drug treatments Piperidines - administration & dosage Piperidines - adverse effects Probability Survival Analysis Tomography, X-Ray Computed Treatment Outcome
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