The Hsp90 chaperone complex as a novel target for cancer therapy

Background: Heat shock protein 90 (Hsp90) is responsible for chaperoning proteins involved in cell signaling, proliferation and survival. 17-allylamino-17-demethoxygeldanamycin (17-AAG) is an anticancer agent currently in phase I trials in the USA and UK. It represents a class of drugs, the benzoqui...

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Veröffentlicht in:	Annals of oncology 2003-08, Vol.14 (8), p.1169-1176
Hauptverfasser:	Goetz, M. P., Toft, D. O., Ames, M. M., Erlichman, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzoquinones Biological and medical sciences Clinical Trials, Phase I as Topic Disease Models, Animal Female Forecasting General aspects heat shock protein Hsp90 HSP90 Heat-Shock Proteins - drug effects HSP90 Heat-Shock Proteins - metabolism Humans Key words: 17-AAG Lactams, Macrocyclic Male Medical sciences Mice Neoplasms - diagnosis Neoplasms - drug therapy Pharmacology. Drug treatments Quinones - pharmacology Quinones - therapeutic use Rifabutin - analogs & derivatives Rifabutin - pharmacology Rifabutin - therapeutic use Sensitivity and Specificity Signal Transduction - drug effects
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