Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma
Background: Members of the Eph family of tyrosine kinases have been implicated in embryonic pattern formation and vascular development; however, little is known about their role in the adult organism. We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implicatio...
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| Veröffentlicht in: | Annals of oncology 2003-02, Vol.14 (2), p.220-226 |
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| container_title | Annals of oncology |
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| creator | Berclaz, G. Karamitopoulou, E. Mazzucchelli, L. Rohrbach, V. Dreher, E. Ziemiecki, A. Andres, A.-C. |
| description | Background: Members of the Eph family of tyrosine kinases have been implicated in embryonic pattern formation and vascular development; however, little is known about their role in the adult organism. We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ. Since the endometrium is a similarly hormone dependent organ and endometrial carcinoma is thought to result from estrogenic stimulation, we have investigated EphB4 expression in normal human endometrium and during its carcinogenesis. Patients and methods: EphB4 expression was analyzed immunohistochemically in 26 normal endometrium specimens, 15 hyperplasias and 102 endometrioid adenocarcinomas and correlated with clinical and prognostic tumor characteristics. Results: In normal endometrial tissue no EphB4 protein was detected. Strikingly, we observed a drastic increase (P |
| doi_str_mv | 10.1093/annonc/mdg072 |
| format | Article |
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We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ. Since the endometrium is a similarly hormone dependent organ and endometrial carcinoma is thought to result from estrogenic stimulation, we have investigated EphB4 expression in normal human endometrium and during its carcinogenesis. Patients and methods: EphB4 expression was analyzed immunohistochemically in 26 normal endometrium specimens, 15 hyperplasias and 102 endometrioid adenocarcinomas and correlated with clinical and prognostic tumor characteristics. Results: In normal endometrial tissue no EphB4 protein was detected. Strikingly, we observed a drastic increase (P <0.0001) in the number of EphB4 protein-expressing glandular epithelial cells in the majority of hyperplasias and carcinomas. Moreover, we found a statistically highly significant positive correlation between EphB4 expression and post-menopausal stage of the patient (P = 0.007). Conclusions: These findings indicate that in the endometrium, EphB4 is an early indicator of malignant development and, thus, EphB4 may represent a potent tool for diagnosis and therapeutic intervention.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdg072</identifier><identifier>PMID: 12562648</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma - genetics ; Carcinoma - physiopathology ; Endometrial Hyperplasia - genetics ; Endometrial Hyperplasia - physiopathology ; Endometrial Neoplasms - genetics ; Endometrial Neoplasms - physiopathology ; Female ; Female genital diseases ; Gene Expression Regulation, Neoplastic ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Key words: endometrial cancer ; Medical sciences ; Middle Aged ; Receptor, EphB4 - biosynthesis ; Tumors ; tyrosine kinase</subject><ispartof>Annals of oncology, 2003-02, Vol.14 (2), p.220-226</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-7f4e9fce02c374b7bb135a8949db7ea09974428b715d1fe172ed1d86cf12dc43</citedby><cites>FETCH-LOGICAL-c396t-7f4e9fce02c374b7bb135a8949db7ea09974428b715d1fe172ed1d86cf12dc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14517326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12562648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berclaz, G.</creatorcontrib><creatorcontrib>Karamitopoulou, E.</creatorcontrib><creatorcontrib>Mazzucchelli, L.</creatorcontrib><creatorcontrib>Rohrbach, V.</creatorcontrib><creatorcontrib>Dreher, E.</creatorcontrib><creatorcontrib>Ziemiecki, A.</creatorcontrib><creatorcontrib>Andres, A.-C.</creatorcontrib><title>Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Background: Members of the Eph family of tyrosine kinases have been implicated in embryonic pattern formation and vascular development; however, little is known about their role in the adult organism. We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ. Since the endometrium is a similarly hormone dependent organ and endometrial carcinoma is thought to result from estrogenic stimulation, we have investigated EphB4 expression in normal human endometrium and during its carcinogenesis. Patients and methods: EphB4 expression was analyzed immunohistochemically in 26 normal endometrium specimens, 15 hyperplasias and 102 endometrioid adenocarcinomas and correlated with clinical and prognostic tumor characteristics. Results: In normal endometrial tissue no EphB4 protein was detected. Strikingly, we observed a drastic increase (P <0.0001) in the number of EphB4 protein-expressing glandular epithelial cells in the majority of hyperplasias and carcinomas. Moreover, we found a statistically highly significant positive correlation between EphB4 expression and post-menopausal stage of the patient (P = 0.007). Conclusions: These findings indicate that in the endometrium, EphB4 is an early indicator of malignant development and, thus, EphB4 may represent a potent tool for diagnosis and therapeutic intervention.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - physiopathology</subject><subject>Endometrial Hyperplasia - genetics</subject><subject>Endometrial Hyperplasia - physiopathology</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Endometrial Neoplasms - physiopathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Key words: endometrial cancer</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptor, EphB4 - biosynthesis</subject><subject>Tumors</subject><subject>tyrosine kinase</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1rGzEQQEVpiB03x16LLj1urK9drY5pyEfB0ITkEHoRs9JsrcarXSSl1P8-DjY1Pc3hPWaGR8hnzi44M3IJMY7RLQf_i2nxgcx53ZiqZYp_JHNmhKx0LdWMnOX8mzHWGGFOyYyLuhGNaudkuHQl_IESxkjHnpY10oQOpzImOqWxYIi0bNOYQ0T6EiJkpNfT-puiO4DRjwOWFGBD19sJ07SBHIBC9P8xB8mFOA7wiZz0sMl4fpgL8nRz_XR1V61-3H6_ulxVTpqmVLpXaHqHTDipVae7jssaWqOM7zQCM0YrJdpO89rzHrkW6LlvG9dz4Z2SC1Lt17rd4zlhb6cUBkhby5l9r2b31ey-2s7_sven125Af7QPmXbC14MA2cGmTxBdyEdP1VxL0RwPh1zw7z8O6cU2Wura3j3_tA_Pjzfqnmt7L98AinWJOA</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Berclaz, G.</creator><creator>Karamitopoulou, E.</creator><creator>Mazzucchelli, L.</creator><creator>Rohrbach, V.</creator><creator>Dreher, E.</creator><creator>Ziemiecki, A.</creator><creator>Andres, A.-C.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030201</creationdate><title>Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma</title><author>Berclaz, G. ; Karamitopoulou, E. ; Mazzucchelli, L. ; Rohrbach, V. ; Dreher, E. ; Ziemiecki, A. ; Andres, A.-C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-7f4e9fce02c374b7bb135a8949db7ea09974428b715d1fe172ed1d86cf12dc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - physiopathology</topic><topic>Endometrial Hyperplasia - genetics</topic><topic>Endometrial Hyperplasia - physiopathology</topic><topic>Endometrial Neoplasms - genetics</topic><topic>Endometrial Neoplasms - physiopathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Key words: endometrial cancer</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptor, EphB4 - biosynthesis</topic><topic>Tumors</topic><topic>tyrosine kinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berclaz, G.</creatorcontrib><creatorcontrib>Karamitopoulou, E.</creatorcontrib><creatorcontrib>Mazzucchelli, L.</creatorcontrib><creatorcontrib>Rohrbach, V.</creatorcontrib><creatorcontrib>Dreher, E.</creatorcontrib><creatorcontrib>Ziemiecki, A.</creatorcontrib><creatorcontrib>Andres, A.-C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berclaz, G.</au><au>Karamitopoulou, E.</au><au>Mazzucchelli, L.</au><au>Rohrbach, V.</au><au>Dreher, E.</au><au>Ziemiecki, A.</au><au>Andres, A.-C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>14</volume><issue>2</issue><spage>220</spage><epage>226</epage><pages>220-226</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Background: Members of the Eph family of tyrosine kinases have been implicated in embryonic pattern formation and vascular development; however, little is known about their role in the adult organism. We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ. Since the endometrium is a similarly hormone dependent organ and endometrial carcinoma is thought to result from estrogenic stimulation, we have investigated EphB4 expression in normal human endometrium and during its carcinogenesis. Patients and methods: EphB4 expression was analyzed immunohistochemically in 26 normal endometrium specimens, 15 hyperplasias and 102 endometrioid adenocarcinomas and correlated with clinical and prognostic tumor characteristics. Results: In normal endometrial tissue no EphB4 protein was detected. Strikingly, we observed a drastic increase (P <0.0001) in the number of EphB4 protein-expressing glandular epithelial cells in the majority of hyperplasias and carcinomas. Moreover, we found a statistically highly significant positive correlation between EphB4 expression and post-menopausal stage of the patient (P = 0.007). Conclusions: These findings indicate that in the endometrium, EphB4 is an early indicator of malignant development and, thus, EphB4 may represent a potent tool for diagnosis and therapeutic intervention.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12562648</pmid><doi>10.1093/annonc/mdg072</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma - genetics Carcinoma - physiopathology Endometrial Hyperplasia - genetics Endometrial Hyperplasia - physiopathology Endometrial Neoplasms - genetics Endometrial Neoplasms - physiopathology Female Female genital diseases Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Key words: endometrial cancer Medical sciences Middle Aged Receptor, EphB4 - biosynthesis Tumors tyrosine kinase |
| title | Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma |
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