Optimization of 5-fluorouracil (5-FU)/cisplatin combination chemotherapy with a new schedule of leucovorin, 5-FU and cisplatin (LV5FU2-P regimen) in patients with biliary tract carcinoma

Background: Unresectable biliary tract carcinoma (BTC) is associated with a very poor prognosis. To improve efficacy and tolerance of the 5-fluorouracil (5-FU)/cisplatin combination in BTC, we designed a new therapeutic schedule, the LV5FU2-P regimen. Patients and methods: Twenty-nine patients with...

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Veröffentlicht in:	Annals of oncology 2002-08, Vol.13 (8), p.1192-1196
Hauptverfasser:	Taïeb, J., Mitry, E., Boige, V., Artru, P., Ezenfis, J., Lecomte, T., Clavero-Fabri, M. C., Vaillant, J. N., Rougier, P., Ducreux, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Adenocarcinoma - drug therapy Adenocarcinoma - secondary Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - pathology Biological and medical sciences Chemotherapy Cholangiocarcinoma - drug therapy Cholangiocarcinoma - pathology cisplatin Cisplatin - administration & dosage Female Fluorouracil - administration & dosage Gastrointestinal Diseases - chemically induced Humans Key words: biliary tract carcinoma Leucovorin - administration & dosage Liver Neoplasms - drug therapy Liver Neoplasms - secondary Lung Neoplasms - drug therapy Lung Neoplasms - secondary Lymphatic Metastasis Male Medical sciences Middle Aged Neutropenia - chemically induced Pharmacology. Drug treatments Prospective Studies Survival Rate Thrombocytopenia - chemically induced Treatment Outcome
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