Vitamin B6 prevents Isocarbophos-induced posterior cerebral artery injury in offspring rats through up-regulating S1P receptor expression

Abstract We have previously reported that the long-term exposure of Isocarbophos, a kind of organophosphorus compounds, induces vascular dementia (VD) in rats. Studies have also shown that organophosphorus compounds have adverse effects on offsprings. Vitamin B6 is a coenzyme mainly involved in the...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2021-12, Vol.53 (12), p.1691-1701
Hauptverfasser:	Liu, Yanhua, Yang, Kunli, Wang, Ling, Yang, Jinfang, Wang, Yang, Luo, Hu, Li, Peng, Yin, Yaling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - drug effects Animals Apoptosis - drug effects Caspase 3 - metabolism Cerebral Arterial Diseases - pathology Cerebral Arterial Diseases - prevention & control Cytokines - metabolism Disease Models, Animal Female Hypoxia - chemically induced Hypoxia - prevention & control Insecticides - toxicity Lysophospholipids - metabolism Malathion - analogs & derivatives Malathion - toxicity Male Malondialdehyde - blood Malondialdehyde - metabolism Maternal Exposure - adverse effects Nitric Oxide - blood Nitric Oxide - metabolism Paternal Exposure - adverse effects Posterior Cerebral Artery - drug effects Posterior Cerebral Artery - injuries Posterior Cerebral Artery - pathology Protective Agents - pharmacology Protective Agents - therapeutic use Rats Rats, Sprague-Dawley Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine-1-Phosphate Receptors - metabolism Superoxide Dismutase - blood Superoxide Dismutase - metabolism Up-Regulation Vasoconstriction - drug effects Vitamin B 6 - pharmacology Vitamin B 6 - therapeutic use
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