High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression

Abstract Hyperglycemia-mediated reactive oxygen species (ROS) accumulation plays an important role in hyperglycemia-induced endothelial injury. Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibition partici...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta biochimica et biophysica Sinica 2020-05, Vol.52 (5), p.506-516
Hauptverfasser:	Chen, Xiangyuan, Qi, Jie, Wu, Qichao, Jiang, Hui, Wang, Jing, Chen, Wankun, Mao, Anrong, Zhu, Minmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant Response Elements Down-Regulation - drug effects Gene Expression Regulation, Enzymologic - drug effects Glucose - pharmacology Histone-Lysine N-Methyltransferase - biosynthesis Histone-Lysine N-Methyltransferase - genetics Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - pathology Humans Hyperglycemia - genetics Hyperglycemia - metabolism Hyperglycemia - pathology Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Signal Transduction - drug effects Signal Transduction - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!